Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vera Manser"'
Autor:
Joachim Müller, Adriana Aguado-Martinez, Vera Manser, Vreni Balmer, Pablo Winzer, Dominic Ritler, Isabel Hostettler, David Arranz-Solís, Luis Ortega-Mora, Andrew Hemphill
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 1, Pp 16-25 (2015)
The naphthoquinone buparvaquone is currently the only drug used against theileriosis. Here, the effects of buparvaquone were investigated in vitro and in an experimental mouse model for Neospora caninum infection. In 4-day proliferation assays, bupar
Externí odkaz:
https://doaj.org/article/e8cd7d406f2f44b6b5c9a7bb832f4bb1
Publikováno v:
Müller, Joachim; Manser, Vera; Hemphill, Andrew (2019). In vitro treatment of Besnoitia besnoiti with the naphto-quinone buparvaquone results in marked inhibition of tachyzoite proliferation, mitochondrial alterations and rapid adaptation of tachyzoites to increased drug concentrations. Parasitology, 146(1), pp. 112-120. Cambridge University Press 10.1017/S0031182018000975
We here assessed thein vitroefficacy of the naptho-quinone buparvaquone (BPQ) againstBesnoitia besnoititachyzoitesin vitro. BPQ is currently licensed for the treatment of theileriosis in cattle in many countries, but not in the EU. In 4-day treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1858492e12733b0f9a9c6786be1324
https://boris.unibe.ch/127310/1/_system_appendPDF_proof_hi.pdf
https://boris.unibe.ch/127310/1/_system_appendPDF_proof_hi.pdf
Autor:
Mahbubur Rahman, Vera Manser, Vreni Balmer, Pablo Winzer, Andrew Hemphill, Joachim Müller, Richard K. Haynes
Publikováno v:
International journal of antimicrobial agents
From a panel of 34 artemisinin derivatives tested in vitro, artemisone, GC007 and GC012 were most efficacious at inhibiting Neospora caninum replication (IC50 values of 3-54nM), did not notably impair the invasiveness of tachyzoites and were non-toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f61b808ba54a08ad732bdaeebe914f0
https://doi.org/10.1016/j.ijantimicag.2015.02.020
https://doi.org/10.1016/j.ijantimicag.2015.02.020
Autor:
David Arranz-Solís, Isabel Hostettler, Pablo Winzer, Adriana Aguado-Martínez, Dominic Ritler, Vreni Balmer, Vera Manser, Luis Miguel Ortega-Mora, Andrew Hemphill, Joachim Müller
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 1, Pp 16-25 (2015)
International journal for parasitology. Drugs and drug resistance
International Journal for Parasitology: Drugs and Drug Resistance
Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Balmer, Vreni; Winzer, Pablo Arnold; Ritler, Dominic; Hostettler, Isabel; Arranz Solis, David; Ortega-Mora, Luis; Hemphill, Andrew (2015). Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice. International journal for parasitology. Drugs and drug resistance, 5(1), pp. 16-25. Elsevier 10.1016/j.ijpddr.2015.02.001
International journal for parasitology. Drugs and drug resistance
International Journal for Parasitology: Drugs and Drug Resistance
Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Balmer, Vreni; Winzer, Pablo Arnold; Ritler, Dominic; Hostettler, Isabel; Arranz Solis, David; Ortega-Mora, Luis; Hemphill, Andrew (2015). Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice. International journal for parasitology. Drugs and drug resistance, 5(1), pp. 16-25. Elsevier 10.1016/j.ijpddr.2015.02.001
Highlights • Buparvaquone inhibits proliferation of Neospora caninum at nanomolar concentrations. • In vitro, the drug acts mainly parasitostatic. • Parasiticidal effects occur at µmolar concentrations after extended periods of time. • Bupar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5765cb352f0a3285dabec918844ccb
http://www.sciencedirect.com/science/article/pii/S2211320715000032
http://www.sciencedirect.com/science/article/pii/S2211320715000032
Autor:
Andrew Hemphill, Vera Manser, Ho Ning Wong, Richard K. Haynes, Joachim Müller, Adriana Aguado-Martínez
Publikováno v:
Veterinary Research
Veterinary Research, BioMed Central, 2016, 47 (1), pp.32. ⟨10.1186/s13567-016-0317-1⟩
Veterinary research
Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Wong, Ho Ning; Haynes, Richard K; Hemphill, Andrew (2016). Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model. Veterinary research, 47, p. 32. BioMed Central 10.1186/s13567-016-0317-1
Veterinary Research, BioMed Central, 2016, 47 (1), pp.32. ⟨10.1186/s13567-016-0317-1⟩
Veterinary research
Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Wong, Ho Ning; Haynes, Richard K; Hemphill, Andrew (2016). Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model. Veterinary research, 47, p. 32. BioMed Central 10.1186/s13567-016-0317-1
International audience; AbstractThe three anti-malarial drugs artemiside, artemisone, and mefloquine, and the naphthoquinone buparvaquone known to be active against theileriosis in cattle and Leishmania infections in rodents, were assessed for activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d2171308eb1157eeef0f2c1f4b51f3
https://hal.archives-ouvertes.fr/hal-01341484/document
https://hal.archives-ouvertes.fr/hal-01341484/document
Autor:
Vera Manser, Vreni Balmer, Andrew Hemphill, Adriana Aguado-Martínez, Alexandre Leitão, Afonso P. Basto, Joachim Müller
Publikováno v:
Aguado Martinez, Adriana; Silva Pinto Basto, Afonso; Müller, Joachim; Balmer, Vreni; Manser, Vera; Leitão, Alexandre; Hemphill, Andrew (2016). N-terminal fusion of a toll-like receptor 2-ligand to a Neospora caninum chimeric antigen efficiently modifies the properties of the specific immune response. Parasitology, 143(5), pp. 606-616. Cambridge University Press 10.1017/S0031182016000056
SUMMARYImmunoprophylactic products against neosporosis during pregnancy should induce an appropriately balanced immune response. In this respect, OprI, a bacterial lipoprotein targeting toll like receptor (TLR)2, provides promising adjuvant propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ed0157ae7d0bdd618b5747b3edc614
https://pubmed.ncbi.nlm.nih.gov/26932317
https://pubmed.ncbi.nlm.nih.gov/26932317
Autor:
Wesley C. Van Voorhis, Erkang Fan, Vera Manser, Andrew Hemphill, Dustin J. Maly, Joachim Müller, Adriana Aguado-Martínez, Mahbubur Rahman, Kayode K. Ojo, Vreni Balmer, Pablo Winzer, Luis Miguel Ortega-Mora
Publikováno v:
Winzer, Pablo Arnold; Müller, Joachim; Aguado Martinez, Adriana; Rahman, Mahbubur; Balmer, Vreni; Manser, Vera; Ortega-Mora, Luis Miguel; Ojo, Kayode K; Fan, Erkang; Maly, Dustin J; Van Voorhis, Wesley C; Hemphill, Andrew (2015). In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum. Antimicrobial agents and chemotherapy, 59(10), pp. 6361-6374. American Society for Microbiology 10.1128/AAC.01236-15
Antimicrobial agents and chemotherapy
Antimicrobial agents and chemotherapy
We report on the in vitro effects of the bumped kinase inhibitor 1294 (BKI-1294) in cultures of virulent Neospora caninum isolates Nc-Liverpool (Nc-Liv) and Nc-Spain7 and in two strains of Toxoplasma gondii (RH and ME49), all grown in human foreskin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7b9948ee0074c7dea5014049741b88