Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Vera Lukashchuk"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Current barriers to the use of adeno-associated virus serotype 9 (AAV9) in clinical trials for treating neurological disorders are its high expression in many off-target tissues such as liver and heart, and lack of cell specificity within the central
Externí odkaz:
https://doaj.org/article/277aebb8e4f840fda98da39b9a8b4cff
Autor:
Delphine Cuchet-Lourenço, Chris Boutell, Vera Lukashchuk, Kyle Grant, Amanda Sykes, Jill Murray, Anne Orr, Roger D Everett
Publikováno v:
PLoS Pathogens, Vol 7, Iss 7, p e1002123 (2011)
Components of promyelocytic leukaemia (PML) nuclear bodies (ND10) are recruited to sites associated with herpes simplex virus type 1 (HSV-1) genomes soon after they enter the nucleus. This cellular response is linked to intrinsic antiviral resistance
Externí odkaz:
https://doaj.org/article/4beb4b6c3fee4d3b9cba26b8e2ad8b3e
Publikováno v:
Current opinion in biotechnology. 71
HEK293 cell lines are used for the production of recombinant proteins, virus-like particles and viral vectors. Recent work has generated molecular (systems level) characterisation of HEK293 variants that has enabled re-engineering of the cells toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa0668055804032499c678f720ba3d7
https://pubmed.ncbi.nlm.nih.gov/34058525
https://pubmed.ncbi.nlm.nih.gov/34058525
Autor:
Paul Rothwell, Jon Extance, Vera Lukashchuk, Kevin Bowes, Sarah A. Milsom, Lisa J. Caproni, Daniel C. Smith, Kinga Karbowniczek
Publikováno v:
Cell and Gene Therapy Insights. 3:731-738
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c9bdb278f0db7354543efc5a6178a0d
https://doi.org/10.18609/cgti.2017.074
https://doi.org/10.18609/cgti.2017.074
Autor:
Waheba Elsayed, Shih-Chieh Chieh Chiang, Tommaso Iannitti, Mateusz Jurga, Mohamed K. Hassan, Ian Coldicott, Sherif F. El-Khamisy, Kurt J. De Vos, Adrian Higginbottom, Evangelia Karyka, Padraig J. Mulcahy, Vera Lukashchuk, Katherine E. Lewis, Jayanth S. Chandran, Mimoun Azzouz, Pamela J. Shaw, Callum Walker, Swagat Ray, Saul Herranz-Martin, Guillaume M. Hautbergue, Chunyan Liao, Ioannis Tsagakis
Publikováno v:
Nature neuroscience
A hexanucleotide repeat expansion represents the most common genetic cause of\ud amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, though the\ud mechanisms by which the expansion cause neurodegeneration are poorly understood. We\ud rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758fb2bd1ec895b7cc772ca87b8587c4
http://europepmc.org/articles/PMC5578434
http://europepmc.org/articles/PMC5578434
Autor:
Amanda Sykes, Jill Murray, Kyle Grant, Anne Orr, Vera Lukashchuk, Delphine Cuchet-Lourenço, Chris Boutell, Roger D. Everett
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 7, Iss 7, p e1002123 (2011)
PLoS Pathogens, Vol 7, Iss 7, p e1002123 (2011)
Components of promyelocytic leukaemia (PML) nuclear bodies (ND10) are recruited to sites associated with herpes simplex virus type 1 (HSV-1) genomes soon after they enter the nucleus. This cellular response is linked to intrinsic antiviral resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fcbb69dd482ee2efb3fc64330b91293
https://pubmed.ncbi.nlm.nih.gov/21779164
https://pubmed.ncbi.nlm.nih.gov/21779164
Autor:
Vera Lukashchuk, Roger D. Everett
Publikováno v:
Journal of virology. 84(8)
Herpes simplex virus type 1 (HSV-1) immediate-early gene product ICP0 activates lytic infection and relieves cell-mediated repression of viral gene expression. This repression is conferred by preexisting cellular proteins and is commonly referred to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abebb3461e7471f5689e9715ee354336
https://pubmed.ncbi.nlm.nih.gov/20147399
https://pubmed.ncbi.nlm.nih.gov/20147399
The human cytomegalovirus (HCMV) tegument protein pp71, encoded by gene UL82, stimulates viral immediate-early (IE) transcription. pp71 interacts with the cellular protein hDaxx at nuclear domain 10 (ND10) sites, resulting in the reversal of hDaxx-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bdf7f0f52d375075a71d66270a5389
https://europepmc.org/articles/PMC2593304/
https://europepmc.org/articles/PMC2593304/
Publikováno v:
European Journal of Molecular and Clinical Medicine, Vol 2, Iss 1, Pp 12-15 (2014)
Therapeutic targets for neurodegenerative conditions are constantly emerging. Diseases such as amyotrophic lateral sclerosis and Huntington׳s disease are multifactorial and involve dysfunction of various cellular pathways. Protein aggregate formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ab3ae74aafff76c76372c8c6e4e9e0
https://doi.org/10.1016/j.nhtm.2014.08.004
https://doi.org/10.1016/j.nhtm.2014.08.004