Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Vera I. Hashem"'
Publikováno v:
Molecular Carcinogenesis. 48:336-349
The DNA repeats (CTG)·(CAG), (CGG)·(CCG), (GAA)·(TTC), (ATTCT)·(AGAAT), and (CCTG)·(CAGG), undergo expansion in humans leading to neurodegenerative disease. A genetic assay for repeat instability has revealed that the activities of RecA and RecB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba02bc139d0361a15081075f04edf49
https://doi.org/10.1002/mc.20534
https://doi.org/10.1002/mc.20534
Autor:
Elena A. Oussatcheva, Yuri L. Lyubchenko, John J. Bissler, Vladimir N. Potaman, Vera I. Hashem, Lu Lu, Richard R. Sinden, Craig J. Benham, Tohru Matsuura, Luda S. Shlyakhtenko, Michael Leffak, Tetsuo Ashizawa
Publikováno v:
Journal of Molecular Biology. 326:1095-1111
A number of human hereditary diseases have been associated with the instability of DNA repeats in the genome. Recently, spinocerebellar ataxia type 10 has been associated with expansion of the pentanucleotide repeat (ATTCT)(n).(AGAAT)(n) from a norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c9797eb433444080563391d4ffa6fa
https://doi.org/10.1016/s0022-2836(03)00037-8
https://doi.org/10.1016/s0022-2836(03)00037-8
Autor:
Richard R. Sinden, Vera I. Hashem
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 508:107-119
The number of neurodegenerative disorders associated with the expansion of DNA repeats, currently about 18, continues to increase as additional diseases caused by this novel type of mutation are identified. Typically, expanded repeats are biased towa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2be2c3aa54ebbcd1fbb9e3989ce8af7
https://doi.org/10.1016/s0027-5107(02)00190-2
https://doi.org/10.1016/s0027-5107(02)00190-2
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 502:39-46
Escherichia coli has provided an important model system for understanding the molecular basis for genetic instabilities associated with repeated DNA. Changes in triplet repeat length during growth following transformation in E. coli have been used as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb946ff18dd264aa28fbed12aacb921
https://doi.org/10.1016/s0027-5107(02)00027-1
https://doi.org/10.1016/s0027-5107(02)00027-1
Publikováno v:
Annals of the New York Academy of Sciences. 870:173-189
The fidelity of replication has evolved to reproduce B-form DNA accurately, while allowing a low frequency of mutation. The fidelity of replication can be compromised, however, by defined order sequence DNA (dosDNA) that can adopt unusual or non B-DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67c8996e423eca1ac831525ff7dec64
https://doi.org/10.1111/j.1749-6632.1999.tb08878.x
https://doi.org/10.1111/j.1749-6632.1999.tb08878.x
Autor:
Aida Abu-Baker, Tetsuo Ashizawa, Linda L. Bachinski, Albino Bacolla, Gillian P. Bates, John S. Belt, Dya Bezprozvanny, Sanjay Bidichandani, John J. Bissler, Alexis Brice, Kerri M. Carlson, CheunJu Chen, Thomas A. Cooper, Natividad Cortez-Apreza, John W. Day, Irene De Biase, Ruhee Dere, Didier Devys, Katherine A. Dick, Vincent Dion, Lisa M. Ellerby, Henry F. Epstein, Kenneth H. Fischbeck, Laurent Foiry, Rune R. Frants, Gwenn A. Garden, M´rio Gomes-Pereira, Geneviéve Gourdon, Paul J. Hagerman, Randi J Hagerman, Peter S. Harper, Vera I. Hashem, Michael R. Hayden, Micheal L. Hebert, Dominique Helmlinger, Emma Hockly, Susan E. Holmes, H.S. Hwang, Yoshio Ikeda, Kinya Ishikawa, George R. Jackson, Mariana Kekis, Beata Kosmider, Irina V. Kovtun, Ralf Krahe, Wlodzimierz J. Krzyzosiak, Albert R. La Spada, Jacquelynn E. Larson, Rachel Lau, Michael Leffak, Michelle R. Leonard, Yunfu Lin, Yuan Liu, Julien L. Marcadier, Jamie M. Margolis, Russell L. Margolis, Cynthia T. McMurray, Sergei M. Mirkin, Hidehiro Mizusawa, Darren G. Monckton, S. Erin Montgomery, Marek Napierala, David L. Nelson, Elizabeth O'Hearn, Ben A. Oostra, Harry T. Orr, George W. Padberg, Massimo Pandolfo, Gagan B. Panigrahi, Sharan Paul, Henry Paulson, Christopher E. Pearson, Olga Pletnikova, Vladimir N. Potaman, Mahmoud A. Pouladi, Rajendra Prasad, Héléne Puccio, Stefan M. Pulst, Malgorzata J. Pytlos, Laura P.W. Ranum, Lynn A. Raymond, Sita Reddy, Robert I. Richards, Christopher A. Ross, Guy Rouleau, Dobrila D. Rudnicki, Tzu-Kang Sang, Peggy E. Shelbourne, Michael J. Siciliano, Richard R. Sinden, Ram Singh, Krzysztof Sobczak, LesHe S. Son, Giovanni Stevanin, S. Strack, Maurice S. Swanson, J. Paul Taylor, Charles A. Thornton, Andrea Todd, Juan Troncoso, Ray Truant, Bjarne Udd, Karen Usdin, Silvere M. van der Maarel, Rene E.M.A. van Herpen, Caroline Vosch, Derick G. Wansink, Robert D. Wells, Ronald Wetzel, Bé Wieringa, Robert B. Wilson, Samuel H. Wilson, John H. Wilson, Marzena Wojciechowska
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd4cd0ded2f3ce9679528ecf02b5ccd4
https://doi.org/10.1016/b978-012369462-1/50000-4
https://doi.org/10.1016/b978-012369462-1/50000-4
Autor:
Vera I. Hashem, Richard R. Sinden
Publikováno v:
Mutation research. 570(2)
To ascertain a leading or lagging strand preference for duplication mutations, several short DNA sequences, i.e. mutation inserts, were designed that should demonstrate an asymmetric propensity for duplication mutations in the two complementary DNA s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e94facbea4ecf0b912aac9a6a6b24d
https://pubmed.ncbi.nlm.nih.gov/15708580
https://pubmed.ncbi.nlm.nih.gov/15708580
Publikováno v:
Mutation research. 502(1-2)
Genetic selection assays were developed to measure rates of deletion of one or more (CAG).(CTG) repeats, or an entire repeat tract, in Escherichia coli. In-frame insertions of >or=25 repeats in the chloramphenicol acetyltransferase (CAT) gene of pBR3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313074948bd3e8149518565d66454a0b
https://pubmed.ncbi.nlm.nih.gov/11996969
https://pubmed.ncbi.nlm.nih.gov/11996969
Publikováno v:
The Journal of biological chemistry. 276(33)
Several human genetic diseases have been associated with the genetic instability, specifically expansion, of trinucleotide repeat sequences such as (CTG)(n).(CAG)(n). Molecular models of repeat instability imply replication slippage and the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53517db8fd119c7749d6e9fd7758acce
https://pubmed.ncbi.nlm.nih.gov/11413147
https://pubmed.ncbi.nlm.nih.gov/11413147
Autor:
Vera I, Hashem, Malgorzata J, Pytlos, Elzbieta A, Klysik, Kuniko, Tsuji, Mehrdad, Khajavi, Merhdad, Khajav, Tetsuo, Ashizawa, Richard R, Sinden
Publikováno v:
Nucleic Acids Research. 32:6717-6717
Myotonic dystrophy type 1 (DM1) is caused by the expansion of a (CTG)·(CAG) repeat in the DMPK gene on chromosome 19q13.3. At least 17 neurological diseases have similar genetic mutations, the expansion of DNA repeats. In most of these disorders, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af55c6eaef84a198c51b07c3e9eddccd
https://doi.org/10.1093/nar/gki147
https://doi.org/10.1093/nar/gki147