Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Vera Hillewaert"'
Autor:
Thomas N. Kakuda, Atef Halabi, Gernot Klein, Madhu Sanga, Carine Guinard‐Azadian, Monika Kowalik, Katja Nedoschinsky, Julius Nangosyah, Emmanuel Njumbe Ediage, Vera Hillewaert, Peter Verboven, Ivo Goris, Jan Snoeys, Martyn Palmer, Michael Biermer
Publikováno v:
The Journal of Clinical Pharmacology. 63:732-741
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cba13bd19fd72820553526ce012f9e1d
https://doi.org/10.1002/jcph.2214
https://doi.org/10.1002/jcph.2214
Autor:
Joris, Vandenbossche, Jeysen, Yogaratnam, Vera, Hillewaert, Freya, Rasschaert, Willem, Talloen, Jeike, Biewenga, Jan, Snoeys, Thomas N, Kakuda, Martyn, Palmer, Julius, Nangosyah, Michael, Biermer
Publikováno v:
Clinical Pharmacology in Drug Development. 11:1419-1429
The capsid assembly modulator JNJ-56136379 (bersacapavir) disrupts hepatitis B virus replication. It is metabolized via cytochrome P450 (CYP) 3A, but little is known about the drug-drug interactions of JNJ-56136379 when combined with drugs that inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46aeb60d5492b55a4cdaa1a03186527
https://doi.org/10.1002/cpdd.1164
https://doi.org/10.1002/cpdd.1164
Publikováno v:
Bioanalysis. 12:905-918
Aim: Capillary microsampling of 15 μl whole blood from fingersticks or heelsticks was used to collect pharmacokinetic (PK) samples from pediatric subjects in two projects. Results: In a mebendazole multisite study in Ethiopia and Rwanda in subjects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed9102bd89206ef5684793d3647ea72
https://doi.org/10.4155/bio-2020-0054
https://doi.org/10.4155/bio-2020-0054
Autor:
Ed Gane, Man-Fung Yuen, Thomas N Kakuda, Tetsuro Ogawa, Yasushi Takahashi, Nele Goeyvaerts, Isabelle Lonjon-Domanec, Tamisha Vaughan, Thomas Schluep, James Hamilton, Emmanuel Njumbe Ediage, Vera Hillewaert, Jan Snoeys, Oliver Lenz, Willem Talloen, Michael Biermer
Publikováno v:
Antiviral Therapy. 27:135965352210938
Background JNJ-73763989 comprises two hepatitis B virus (HBV)-specific, liver-targeted N-galactosamine-conjugated short interfering RNA triggers, JNJ-73763976 and JNJ-73763924. JNJ-73763989 pharmacokinetics, safety and tolerability were assessed in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a183962973290deca1b3df39e926e0e
https://doi.org/10.1177/13596535221093856
https://doi.org/10.1177/13596535221093856
Autor:
Sofie Deleu, Kurt Spittaels, Thomas N. Kakuda, Lorant Leopold, Vera Hillewaert, Jurgen Vercauteren, Amy Lwin, Richard M. W. Hoetelmans
Publikováno v:
British Journal of Clinical Pharmacology. 84:2663-2672
AIMS: The aim of this study was to evaluate the drug–drug interaction between pimodivir, a novel, non‐nucleoside polymerase basic protein 2 (PB2) subunit inhibitor of the influenza A virus polymerase complex, and oseltamivir, to assess the feasib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3564656db8be8ae61d03fffc94c97ea9
https://doi.org/10.1111/bcp.13733
https://doi.org/10.1111/bcp.13733
Autor:
Martha Gonzalez, Juan Jose Perez-Ruixo, Vera Hillewaert, Sylvain Baruchel, Elizabeth Fox, Belén Valenzuela, Italo Poggesi, Daniele Ouellet
Publikováno v:
Cancer chemotherapy and pharmacology. 84(4)
To characterize the trabectedin population pharmacokinetics in children and adolescent patients with cancer and compare it with the trabectedin pharmacokinetics in adults. Plasma concentrations from ten adolescent and three children with cancer (age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b20772b021f6eb06441ef0123d601e
https://pubmed.ncbi.nlm.nih.gov/31286189
https://pubmed.ncbi.nlm.nih.gov/31286189
Autor:
Moti Ramgopal, Kimberley Brown, Carmen D. Zorrilla, Bryan Baugh, Vera Hillewaert, Olayemi Osiyemi, R Ryan, Herta Crauwels
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 73:268-274
Background Treatment of HIV-1-infected women during pregnancy protects maternal health and reduces the risk of perinatal transmission of HIV-1. However, physiologic changes that occur during pregnancy may affect drug pharmacokinetics. This phase IIIb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdeb0427ccafc664c62051d2c111ea1f
https://doi.org/10.1097/qai.0000000000001068
https://doi.org/10.1097/qai.0000000000001068
Autor:
Greet Meurs, Vera Hillewaert, Ilse Weuts, Ben Van Hove, Scott Bone, Hector Novoa de Armas, Michiel Van Speybroeck, Geert Verreck, Katrien Backx, Loes Verheyen, Emma Kesselaers, Marieke Voets, Katrien Van Geel, David T. Vodak, Casey Jager, Petros A. Psathas, Jens Ceulemans, Monica Vialpando, Marcus E. Brewster, Sophie Lachau-Durand, Peter Boeykens, Stefanie Smulders, Claire Mackie
Publikováno v:
Journal of Pharmaceutical Sciences
This study investigates 3 amorphous technologies to improve the dissolution rate and oral bioavailability of flubendazole (FLU). The selected approaches are (1) a standard spray-dried dispersion with hydroxypropylmethylcellulose (HPMC) E5 or polyviny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba002196fb7c6513354a1161e7e5496
Autor:
Salih Yasin, Kimberley Brown, Herta Crauwels, P Verboven, B. Ryan, Olayemi Osiyemi, Thomas N. Kakuda, Bryan Baugh, Carmen D. Zorrilla, Vera Hillewaert
Publikováno v:
HIV Medicine. 17:643-652
Objectives HIV antiretroviral therapy during pregnancy is recommended to reduce the risk of mother-to-child transmission and for maternal care. Physiological changes during pregnancy can affect pharmacokinetics. The impact of pregnancy was evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83ef7998cc45930e1de2b3e5af466195
https://doi.org/10.1111/hiv.12366
https://doi.org/10.1111/hiv.12366
Autor:
Thales Cardoso, Mohamed Ben M’Barek, Jenny Lin, Lisa Geisler, Harue Igarashi, Jay Schaefgen, Subramanian Ramachandran, Vera Hillewaert, Michael J. Redrup
Publikováno v:
The AAPS Journal. 18:290-293
The importance of appropriate sample management in regulated bioanalysis is undeniable for clinical and non-clinical study support due to the fact that if the samples are compromised at any stage prior to analysis, the study results may be affected.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f61be86e90ef862a831017e35163f0
https://doi.org/10.1208/s12248-016-9869-2
https://doi.org/10.1208/s12248-016-9869-2