Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Vera A. Alferova"'
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 8, Pp 6851-6879 (2023)
The search for new drugs has been greatly accelerated by the emergence of new viruses and drug-resistant strains of known pathogens. Nucleoside analogues (NAs) are a prospective class of antivirals due to known safety profiles, which are important fo
Externí odkaz:
https://doaj.org/article/9efd0c19f32a49179b974caf2c13fb05
Autor:
Petra Straková, Petr Bednář, Jan Kotouček, Jiří Holoubek, Andrea Fořtová, Pavel Svoboda, Michal Štefánik, Ivana Huvarová, Pavlína Šimečková, Josef Mašek, Daniil A. Gvozdev, Igor E. Mikhnovets, Alexey A. Chistov, Timofei D. Nikitin, Maxim S. Krasilnikov, Alexey V. Ustinov, Vera A. Alferova, Vladimir A. Korshun, Daniel Růžek, Luděk Eyer
Publikováno v:
Virus Research, Vol 334, Iss , Pp 199158- (2023)
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted great interest in novel broad-spectrum antivirals, including perylene-related compounds. In the present study, we p
Externí odkaz:
https://doaj.org/article/fd0ab337342043389ef0ffe6c5160678
Publikováno v:
Molecules, Vol 28, Iss 23, p 7890 (2023)
Antibodies and their derivatives (scFv, Fabs, etc.) represent a unique class of biomolecules that combine selectivity with the ability to target drug delivery. Currently, one of the most promising endeavors in this field is the development of molecul
Externí odkaz:
https://doaj.org/article/335877803aae41978d5a31dffbb0cf66
Autor:
Igor E. Mikhnovets, Jiří Holoubek, Irina S. Panina, Jan Kotouček, Daniil A. Gvozdev, Stepan P. Chumakov, Maxim S. Krasilnikov, Mikhail Y. Zhitlov, Evgeny L. Gulyak, Alexey A. Chistov, Timofei D. Nikitin, Vladimir A. Korshun, Roman G. Efremov, Vera A. Alferova, Daniel Růžek, Luděk Eyer, Alexey V. Ustinov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16483 (2023)
Amphipathic perylene derivatives are broad-spectrum antivirals against enveloped viruses that act as fusion inhibitors in a light-dependent manner. The compounds target the lipid bilayer of the viral envelope using the lipophilic perylene moiety and
Externí odkaz:
https://doaj.org/article/bda4991d6ffd48c897d5b76aae98ae10
Autor:
Kseniya A. Mariewskaya, Daniil A. Gvozdev, Alexey A. Chistov, Petra Straková, Ivana Huvarová, Pavel Svoboda, Jan Kotouček, Nikita M. Ivanov, Maxim S. Krasilnikov, Mikhail Y. Zhitlov, Alexandra M. Pak, Igor E. Mikhnovets, Timofei D. Nikitin, Vladimir A. Korshun, Vera A. Alferova, Josef Mašek, Daniel Růžek, Luděk Eyer, Alexey V. Ustinov
Publikováno v:
Molecules, Vol 28, Iss 17, p 6278 (2023)
Perylenylethynyl derivatives have been recognized as broad-spectrum antivirals that target the lipid envelope of enveloped viruses. In this study, we present novel perylenylethynylphenols that exhibit nanomolar or submicromolar antiviral activity aga
Externí odkaz:
https://doaj.org/article/db86fd6f5582467a98c84bd13833176a
Publikováno v:
Antibiotics, Vol 12, Iss 8, p 1340 (2023)
Sensing of antibiotic–bacteria interactions is an important area of research that has gained significant attention in recent years. Antibiotic resistance is a major public health concern, and it is essential to develop new strategies for detecting
Externí odkaz:
https://doaj.org/article/13c1faf0b0dd43cc956e4354dff8215f
Publikováno v:
Life, Vol 13, Iss 5, p 1073 (2023)
Natural scaffolds remain an important basis for drug development. Therefore, approaches to natural bioactive compound discovery attract significant attention. In this account, we summarize modern and emerging trends in the screening and identificatio
Externí odkaz:
https://doaj.org/article/7fbd03b9e6384346ac578f3dba45691f
Autor:
Ksenia A. Sapozhnikova, Evgeny L. Gulyak, Vladimir A. Brylev, Vsevolod A. Misyurin, Sergey D. Oreshkov, Anastasiya V. Alexeeva, Dmitry Yu. Ryazantsev, Maria A. Simonova, Ekaterina V. Ryabukhina, Galina P. Popova, Nataliya A. Tikhonova, Natalia A. Lyzhko, Alexander E. Barmashov, Andrey V. Misyurin, Alexey V. Ustinov, Vera A. Alferova, Vladimir A. Korshun
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5134 (2023)
A universal approach to the construction of antibody–drug conjugates (ADCs) has been developed. It relies on periodate oxidation of naturally present glycans of immunoglobulin G, followed by oxime ligation and, optionally, copper(I)-catalyzed alkyn
Externí odkaz:
https://doaj.org/article/b5bf2e59e5af49ff868a1ecc3e741f27
Autor:
Ksenia A. Sapozhnikova, Evgeny L. Gulyak, Vsevolod A. Misyurin, Maria A. Simonova, Ekaterina V. Ryabukhina, Anastasiya V. Alexeeva, Nataliya A. Tikhonova, Natalia A. Lyzhko, Galina P. Popova, Andrey V. Misyurin, Alexey V. Ustinov, Vladimir A. Korshun, Vera A. Alferova, Dmitry Yu. Ryazantsev, Vladimir A. Brylev
Publikováno v:
Molecules, Vol 28, Iss 1, p 425 (2023)
Fluorescent antibodies have proved to be an invaluable tool for molecular biology and diagnostics. They are routinely produced by modification of lysine residues, which leads to high heterogeneity. As such, their affinity may be compromised if the an
Externí odkaz:
https://doaj.org/article/b462062bf3f444a6a6792430f6e3c587
Autor:
Kseniya A. Mariewskaya, Maxim S. Krasilnikov, Vladimir A. Korshun, Alexey V. Ustinov, Vera A. Alferova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 188 (2022)
Broad antiviral activity in vitro is known for many organic photosensitizers generating reactive oxygen species under irradiation with visible light. Low tissue penetration of visible light prevents further development of antiviral therapeutics based
Externí odkaz:
https://doaj.org/article/8ebcb13125ee413dbdef833b4c782f83