Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Vera, Luginbuehl"'
Publikováno v:
Biotechnology Advances. 58:107917
Chimeric antigen receptor (CAR) technology, and CAR-T cells in particular, have emerged as a new and powerful tool in cancer immunotherapy since demonstrating efficacy against several hematological malignancies. However, despite encouraging clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586ab6bf23b541a5f026428326b6d16d
https://doi.org/10.1016/j.biotechadv.2022.107917
https://doi.org/10.1016/j.biotechadv.2022.107917
A treasure trove of intracellular cancer drug targets remains hidden behind cell membranes. However, engineered pathogen-derived toxins such as Shiga toxins can deliver small or macromolecular drugs to specific intracellular organelles. After binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47774e4431b458762dae428e992a52ec
https://hdl.handle.net/11475/11523
https://hdl.handle.net/11475/11523
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 11:1974-1985
Locally applied bisphosphonates, such as zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::015157a78bbbc594e309d0ae35312ff8
https://doi.org/10.1002/term.2094
https://doi.org/10.1002/term.2094
Publikováno v:
Neurological Research. 36:1001-1010
Objectives: The partial pressure of oxygen (pO2) in brain tumors ranges from 5 to 15%. Nevertheless, the majority of in vitro experiments with glioblastoma multiforme (GBM) cell lines are carried out under an atmospheric pO2 of 19 to 21%. Recently, 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3462628dc5ad3b4aac574a1fa50482
https://doi.org/10.1179/1743132814y.0000000401
https://doi.org/10.1179/1743132814y.0000000401
Autor:
Claudia Hess, Vera Luginbuehl, Katja Nuss, Dennis Reichardt, Kurt Dr. Ruffieux, Brigitte von Rechenberg
Publikováno v:
Journal of Biomedical Materials Research Part B: Applied Biomaterials. :341-352
For use in the prevention of bone infections, a novel controlled release system composed of β-tricalcium phosphate (TCP) granules with biodegradable coatings incorporating the antibiotic drug tetracycline (TC) was developed. Six formulations using p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a44c6f094e367a2162aff83d3c1314b
https://doi.org/10.1002/jbm.b.31520
https://doi.org/10.1002/jbm.b.31520
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 58:197-208
Delivery of growth factors for tissue (e.g. bone, cartilage) or cell repair (e.g. nerves) is about to gain important potential as a future therapeutic tool. Depending on the targeted cell type and its state of differentiation, growth factors can acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb788a58f98036e1d78f3bc36aeeb17
https://doi.org/10.1016/j.ejpb.2004.03.004
https://doi.org/10.1016/j.ejpb.2004.03.004
Autor:
Oscar E. Illi, Regula Bettschart-Wolfisberger, Rebecca Schneider, Bruno Gander, Evangelos Zoidis, Hans P. Merkle, Paulo Hassa, Jörg A Auer, Vera Luginbuehl, Brigitte von Rechenberg, Lorenz Meinel, Michael O. Hottiger, Jürgen Zapf
Publikováno v:
Bone. 33:660-672
Insulin-like growth factor I (IGF I) exerts an important role during skeletal growth and bone formation. Therefore, its localized delivery appears attractive for the treatment of bone defects. To prolong IGF I delivery, we entrapped the protein into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69330cc2163264b4dc3845778959b878
https://doi.org/10.1016/s8756-3282(03)00207-2
https://doi.org/10.1016/s8756-3282(03)00207-2
Autor:
Pilar Ruiz-Sánchez, Urs Ziegler, Bernhard Spingler, Riccardo Rubbiani, Susmita Gupta, Gunnar Jeschke, Patchanita Thamyongkit, Anu Naik, Philipp M. Antoni, Pornkanok Munikorn, Gilles Gasser, Ina Albert, José María Mateos, Vera Luginbuehl
Novel photoactive (metallo)porphyrins were synthesised and characterised. When irradiated with light at a wavelength greater than 600 nm, these porphyrins act as photosensitisers and show high cytotoxicity towards two different human cancer cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a915c79b91275bc6c1be677641f3b5
https://hdl.handle.net/11475/12931
https://hdl.handle.net/11475/12931
Autor:
Vera Luginbuehl, Bruno Gander, Lorenz Meinel, Brigitte von Rechenberg, Hans P. Merkle, Evangelos Zoidis
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 85(1)
Spatiotemporal release of growth factors from a delivery device can profoundly affect the efficacy of bone growth induction. Here, we report on a delivery platform based on the encapsulation of insulin-like growth factor I (IGF-I) in different poly(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ea196b606856615523b459b4334dd9
https://pubmed.ncbi.nlm.nih.gov/23958321
https://pubmed.ncbi.nlm.nih.gov/23958321
Epileptic seizures are among the presenting clinical signs of malignant glioma patients, frequently necessitating treatment with antiepileptic drugs (AEDs). The efficacy of 5-aminolevulinic acid (5-ALA)-based intraoperative fluorescence-guided surger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4af0ba487241e7a5cfa7e7db82bf2a
https://hdl.handle.net/11475/12923
https://hdl.handle.net/11475/12923