Zobrazeno 1 - 10
of 349
pro vyhledávání: '"Vera, Gorbunova"'
Autor:
Masaki Takasugi, Yoshiki Nonaka, Kazuaki Takemura, Yuya Yoshida, Frank Stein, Jennifer J. Schwarz, Jun Adachi, Junko Satoh, Shinji Ito, Gregory Tombline, Seyed Ali Biashad, Andrei Seluanov, Vera Gorbunova, Naoko Ohtani
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract To what extent and how post-transcriptional dysregulation affects aging proteome remains unclear. Here, we provide proteomic data of whole-tissue lysates (WTL) and low-solubility protein-enriched fractions (LSF) of major tissues collected fr
Externí odkaz:
https://doaj.org/article/ad6e07f0f47841f7905053022225202d
Autor:
Jan Frohlich, Niccolò Liorni, Manuel Mangoni, Gabriela Lochmanová, Pavlína Pírek, Nikola Kaštánková, Pille Pata, Jan Kucera, George N. Chaldakov, Anton B. Tonchev, Illar Pata, Vera Gorbunova, Eric Leire, Zbyněk Zdráhal, Tommaso Mazza, Manlio Vinciguerra
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Obesity is a major health burden. Preadipocytes proliferate and differentiate in mature adipocytes in the adipogenic process, which could be a potential therapeutic approach for obesity. Deficiency of SIRT6, a stress-responsive pr
Externí odkaz:
https://doaj.org/article/2fd96820fdfd4c449cf7c617509a6899
Autor:
Jeremy McGuire, Taketo Taguchi, Gregory Tombline, Victoria Paige, Michelle Janelsins, Nikesha Gilmore, Andrei Seluanov, Vera Gorbunova
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cancer remains a formidable global health challenge, with metastasis being a key contributor to its lethality. Abundant high molecular mass hyaluronic acid, a major non-protein component of extracellular matrix, protects naked mole rats from
Externí odkaz:
https://doaj.org/article/b7b21f6e8b2b44c793bf4e3b4ec5f552
Autor:
Guillem Sanchez Sanchez, Stephan Emmrich, Maria Georga, Ariadni Papadaki, Sofia Kossida, Andrei Seluanov, Vera Gorbunova, David Vermijlen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The naked mole-rat (Heterocephalus glaber) is a long-lived rodent species showing resistance to the development of cancer. Although naked mole-rats have been reported to lack natural killer (NK) cells, γδ T cell-based immunity has been sug
Externí odkaz:
https://doaj.org/article/970d6d6c914b40d288848290a521feea
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106675- (2024)
α-synuclein (αSyn) is a presynaptic and nuclear protein that aggregates in important neurodegenerative diseases such as Parkinson's Disease (PD), Parkinson's Disease Dementia (PDD) and Lewy Body Dementia (LBD). Our past work suggests that nuclear
Externí odkaz:
https://doaj.org/article/21878170bbf543eb8878f2c707f5951b
Autor:
Yang Zhao, Zhizhong Zheng, Zhihui Zhang, Yandong Xu, Eric Hillpot, Yifei S. Lin, Frances T. Zakusilo, J. Yuyang Lu, Julia Ablaeva, Seyed Ali Biashad, Richard A. Miller, Eviatar Nevo, Andrei Seluanov, Vera Gorbunova
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Hyaluronic acid is a major component of extracellular matrix which plays an important role in development, cellular response to injury and inflammation, cell migration, and cancer. The naked mole-rat (Heterocephalus glaber) contains abundant
Externí odkaz:
https://doaj.org/article/61acd860f2a148988e96ad8b36cda67f
Autor:
Svetlana A. Romanenko, Sergei F. Kliver, Natalia A. Serdyukova, Polina L. Perelman, Vladimir A. Trifonov, Andrei Seluanov, Vera Gorbunova, Jorge Azpurua, Jorge C. Pereira, Malcolm A. Ferguson-Smith, Alexander S. Graphodatsky
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Descriptions of karyotypes of many animal species are currently available. In addition, there has been a significant increase in the number of sequenced genomes and an ever-improving quality of genome assembly. To close the gap between genom
Externí odkaz:
https://doaj.org/article/ca498ddbda4e49208921343989450939
Autor:
Patrick Treat Paine, Cheyenne Rechsteiner, Francesco Morandini, Gabriela Desdín-Micó, Calida Mrabti, Alberto Parras, Amin Haghani, Robert Brooke, Steve Horvath, Andrei Seluanov, Vera Gorbunova, Alejandro Ocampo
Publikováno v:
Frontiers in Aging, Vol 4 (2024)
Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach a state of replicative senescence, pluripotent stem cells can indefinitely replenish themselves while retaining full homeostatic capacity. The conferment of
Externí odkaz:
https://doaj.org/article/3cf34d95781547ddadab3e678f935ae3
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
Externí odkaz:
https://doaj.org/article/22796d88d135490ea06c2e6feafa8c51
Autor:
Masaki Takasugi, Naoko Ohtani, Kazuaki Takemura, Stephan Emmrich, Frances T. Zakusilo, Yuya Yoshida, Nobuyuki Kutsukake, John N. Mariani, Martha S. Windrem, Devin Chandler-Militello, Steven A. Goldman, Junko Satoh, Shinji Ito, Andrei Seluanov, Vera Gorbunova
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113130- (2023)
Summary: The naked mole rat (NMR) is the longest-lived rodent, resistant to multiple age-related diseases including neurodegeneration. However, the mechanisms underlying the NMR’s resistance to neurodegenerative diseases remain elusive. Here, we is
Externí odkaz:
https://doaj.org/article/04f80f73b8014e2e83d91863b9a4d47c