Bladder cancer organoids as a functional system to model different disease stages and therapy response

Autor: Martina Minoli, Thomas Cantore, Daniel Hanhart, Mirjam Kiener, Tarcisio Fedrizzi, Federico La Manna, Sofia Karkampouna, Panagiotis Chouvardas, Vera Genitsch, Antonio Rodriguez-Calero, Eva Compérat, Irena Klima, Paola Gasperini, Bernhard Kiss, Roland Seiler, Francesca Demichelis, George N. Thalmann, Marianna Kruithof-de Julio

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Bladder Cancer (BLCa) inter-patient heterogeneity is the primary cause of treatment failure, suggesting that patients could benefit from a more personalized treatment approach. Patient-derived organoids (PDOs) have been successfully used as

Externí odkaz: https://doaj.org/article/506bcb5c022948ab961b87996aa3927e

Patient-derived xenografts and organoids model therapy response in prostate cancer

Autor: Sofia Karkampouna, Federico La Manna, Andrej Benjak, Mirjam Kiener, Marta De Menna, Eugenio Zoni, Joël Grosjean, Irena Klima, Andrea Garofoli, Marco Bolis, Arianna Vallerga, Jean-Philippe Theurillat, Maria R. De Filippo, Vera Genitsch, David Keller, Tijmen H. Booij, Christian U. Stirnimann, Kenneth Eng, Andrea Sboner, Charlotte K. Y. Ng, Salvatore Piscuoglio, Peter C. Gray, Martin Spahn, Mark A. Rubin, George N. Thalmann, Marianna Kruithof-de Julio

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

To date, patients still succumb to cancer, due to tumors not responding to therapy or ultimately acquiring resistance. Here the authors show that by exploiting patient derived organoids and a treatment-naïve patient derived xenograft, patient therap

Externí odkaz: https://doaj.org/article/74f8126482f64e7aa57d9156cdf767c0

Supplementary Data from DNA Methylation Landscapes of Prostate Cancer Brain Metastasis Are Shaped by Early Driver Genetic Alterations

Autor: Salvatore Piscuoglio, Mark A. Rubin, Charlotte K.Y. Ng, Silke Gillessen, Felix Y. Feng, George Thalmann, Holger Moch, Lukas Bubendorf, Adeboye O. Osunkoya, Gieri Cathomas, Wolfram Jochum, Ingeborg Fischer, Rainer Grobholz, Elisabeth J. Rushing, Achim Fleischmann, Vera Genitsch, Ekkehard Hewer, Ursula Amstutz, Sina Maletti, Dilara Akhoundova, Andrej Benjak, Antonio Rodriguez-Calero, John Gallon

Supplementary Figures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31537626d7387b9e175d57cbe162c35d
https://doi.org/10.1158/0008-5472.22633061

DNA methylation landscapes of prostate cancer brain metastasis are shaped by early driver genetic alterations

Autor: John Gallon, Antonio Rodriguez-Calero, Andrej Benjak, Dilara Akhoundova, Sina Maletti, Ursula Amstutz, Ekkehard Hewer, Vera Genitsch, Achim Fleischmann, Elisabeth J. Rushing, Rainer Grobholz, Ingeborg Fischer, Wolfram Jochum, Gieri Cathomas, Adeboye O. Osunkoya, Lukas Bubendorf, Holger Moch, George Thalmann, Felix Y. Feng, Silke Gillessen, Charlotte K.Y. Ng, Mark A. Rubin, Salvatore Piscuoglio

Publikováno v: Gallon, John; Rodríguez-Calero, Antonio; Benjak, Andrej; Akhoundova, Dilara; Maletti, Sina; Amstutz, Ursula; Hewer, Ekkehard; Genitsch, Vera; Fleischmann, Achim; Rushing, Elisabeth J; Grobholz, Rainer; Fischer, Ingeborg; Jochum, Wolfram; Cathomas, Gieri; Osunkoya, Adeboye O; Bubendorf, Lukas; Moch, Holger; Thalmann, George; Feng, Felix Y; Gillessen, Silke; ... (2023). DNA methylation landscapes of prostate cancer brain metastasis are shaped by early driver genetic alterations. Cancer research, 83(8), pp. 1203-1213. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-22-2236
Cancer research, vol. 83, no. 8, pp. 1203-1213

Metastases from primary prostate cancers to rare locations, such as the brain, are becoming more common due to longer life expectancy resulting from improved treatments. Epigenetic dysregulation is a feature of primary prostate cancer, and distinct D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce9031aefed757cc227ffba65be48c1
https://boris.unibe.ch/178505/1/can-22-2236.pdf

The ESRP1-GPR137 axis contributes to intestinal pathogenesis

Autor: Lukas Franz Mager, Viktor Hendrik Koelzer, Regula Stuber, Lester Thoo, Irene Keller, Ivonne Koeck, Maya Langenegger, Cedric Simillion, Simona P Pfister, Martin Faderl, Vera Genitsch, Irina Tcymbarevich, Pascal Juillerat, Xiaohong Li, Yu Xia, Eva Karamitopoulou, Ruth Lyck, Inti Zlobec, Siegfried Hapfelmeier, Rémy Bruggmann, Kathy D McCoy, Andrew J Macpherson, Christoph Müller, Bruce Beutler, Philippe Krebs

Publikováno v: eLife, Vol 6 (2017)

Aberrant alternative pre-mRNA splicing (AS) events have been associated with several disorders. However, it is unclear whether deregulated AS directly contributes to disease. Here, we reveal a critical role of the AS regulator epithelial splicing reg

Externí odkaz: https://doaj.org/article/46127925fa504c6795248c15aa1ffdf6