Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies.

Autor: Joyce C; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America., Murrell S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America., Murrell B; Department of Medicine, University of California San Diego, San Diego, California, United States of America.; Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, Stockholm, Sweden., Omorodion O; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America., Ver LS; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI, New York, New York, United States of America., Carrico N; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI, New York, New York, United States of America., Bastidas R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America., Nedellec R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America., Bick M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America., Woehl J; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI, New York, New York, United States of America., Zhao F; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America., Burns A; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI, New York, New York, United States of America., Barman S; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI, New York, New York, United States of America., Appel M; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI, New York, New York, United States of America., Ramos A; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI, New York, New York, United States of America., Wickramasinghe L; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI, New York, New York, United States of America., Eren K; Department of Medicine, University of California San Diego, San Diego, California, United States of America., Vollbrecht T; Department of Medicine, University of California San Diego, San Diego, California, United States of America.; Veterans Affairs San Diego Healthcare System, San Diego, California, United States of America., Smith DM; Department of Medicine, University of California San Diego, San Diego, California, United States of America., Kosakovsky Pond SL; Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, Pennsylvania, United States of America., McBride R; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, United States of America., Worth C; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, United States of America., Batista F; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America., Sok D; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI, New York, New York, United States of America., Poignard P; Institut de Biologie Structurale, Université Grenoble Alpes, Commissariat à l'Energie Atomique, Centre National de Recherche Scientifique and Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France., Briney B; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, California, United States of America., Wilson IA; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America., Landais E; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI, New York, New York, United States of America., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2023 Jun 29; Vol. 19 (6), pp. e1011416. Date of Electronic Publication: 2023 Jun 29 (Print Publication: 2023).

Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch.

Autor: MacLeod DT; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10038, USA., Choi NM; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10038, USA., Briney B; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA., Garces F; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Integrative Structural and Computational Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA., Ver LS; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10038, USA., Landais E; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10038, USA., Murrell B; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA., Wrin T; Monogram Biosciences Inc., San Francisco, CA, 94080, USA., Kilembe W; Zambia-Emory HIV Research Project, Lusaka, Zambia., Liang CH; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA., Ramos A; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10038, USA., Bian CB; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10038, USA., Wickramasinghe L; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10038, USA., Kong L; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Integrative Structural and Computational Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA., Eren K; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA., Wu CY; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan., Wong CH; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan., Kosakovsky Pond SL; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA., Wilson IA; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Integrative Structural and Computational Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA., Burton DR; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Poignard P; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10038, USA; Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, 38044 Grenoble, France. Electronic address: poignard@scripps.edu.

Publikováno v: Immunity [Immunity] 2016 May 17; Vol. 44 (5), pp. 1215-26.

Lung histopathological findings in fatal pandemic influenza A (H1N1).

Autor: Nin N; Hospital Universitario de Getafe, Madrid, Spain., Sánchez-Rodríguez C, Ver LS, Cardinal P, Ferruelo A, Soto L, Deicas A, Campos N, Rocha O, Ceraso DH, El-Assar M, Ortín J, Fernández-Segoviano P, Esteban A, Lorente JA

Publikováno v: Medicina intensiva [Med Intensiva] 2012 Jan-Feb; Vol. 36 (1), pp. 24-31. Date of Electronic Publication: 2011 Dec 10.

Low-pH-induced membrane fusion mediated by human metapneumovirus F protein is a rare, strain-dependent phenomenon.

Autor: Herfst S; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands., Mas V, Ver LS, Wierda RJ, Osterhaus AD, Fouchier RA, Melero JA

Publikováno v: Journal of virology [J Virol] 2008 Sep; Vol. 82 (17), pp. 8891-5. Date of Electronic Publication: 2008 Jul 02.