Effect of the bench scale extraction conditions on Pinus radiata bark extract yield, antioxidant properties and composition

Autor: Valentina Ramos, Carlos Bocalandro, Sebastián Riquelme, Verónica Sanhueza, Estrella Aspé, Marlene Roeckel, Katherina Fernández

Publikováno v: Maderas: Ciencia y Tecnología, Vol 15, Iss 1 (2014)

Many pine bark extracts have antioxidant properties. This work examined bench scale extraction on the yield, the composition and antioxidant properties of Pinus radiata. Acetone solvent (98.7% w/w at 120 °C) yielded maximum phenols concentration, ta

Externí odkaz: https://doaj.org/article/8c864c5f2ae9435b88ae60a83777aa4f

Epigenome‐Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer

Autor: Benjamin Goeppert, Gonzalo de Toro, Johannes Brägelmann, Valentina Garate-Calderon, Melanie Waldenberger, Justo Lorenzo Bermejo, Felix Boekstegers, Erik Morales, Katherine Marcelain, Sinan Uğur Umu, María Teresa Rivera, Carol Barahona Ponce, Stephanie Roessler, Fernando Gabler, Verónica Sanhueza, Eva Reischl, Odilia Popanda, Alejandro Ortega, Bettina Müller, Iván Gallegos, Dominique Scherer, Trine B. Rounge, Alicia Colombo

Publikováno v: Hepatology 73, 2293-2310 (2021)
Hepatology

BACKGROUND AND AIMS Gallbladder cancer (GBC) is a highly aggressive malignancy of the biliary tract. Most cases of GBC are diagnosed in low-income and middle-income countries, and research into this disease has long been limited. In this study we the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b31469052902e9fb82b859fa5530a0e
https://doi.org/10.1002/hep.31585

Validation of an NGS Panel Designed for Detection of Actionable Mutations in Tumors Common in Latin America

Autor: Eva Bustamante, Nicolás Miranda-González, Alicia Colombo, Monica Ahumada, María Loreto Bravo, Justo Lorenzo Bermejo, Katherine Marcelain, Ignacio Maureira, Erik Morales, Lorena Gutiérrez, Verónica Sanhueza, Gonzalo de Toro, Jessica Toro, Evelin González-Feliú, Carolina Ibañez, Ricardo A. Verdugo, Ricardo Armisen, Iván Gallegos, Carolina Bizama, M. Loreto Spencer, Patricia García, Mauricio Salvo, Camilo Villamán, Olga Barajas, Ana María Carrasco

Publikováno v: Journal of Personalized Medicine
Volume 11
Issue 9
Journal of Personalized Medicine, Vol 11, Iss 899, p 899 (2021)

Next-generation sequencing (NGS) is progressively being used in clinical practice. However, several barriers preclude using this technology for precision oncology in most Latin American countries. To overcome some of these barriers, we have designed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0942e31bd542d35cc5173b8d20591fd8
https://doi.org/10.3390/jpm11090899

ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans

Autor: Olga Barajas, Domingo Montalvo, Andrés Ruiz Linares, Monica Ahumada, Sergio Portiño, Carla Gallo, Macarena Fuentes Guajardo, Verónica Sanhueza, Francisco Rothhammer, Melanie Waldenberger, Lorena Gutiérrez, Gonzalo de Toro, Justo Lorenzo Bermejo, Maria Enriqueta Bertrán, María Teresa Rivera, Krista Fischer, Christine Fischer, Maria C. Bortolini, Rosa González Silos, Alejandro Ortega, Denisse Loader, Niina Eklund, Jordi Olloquequi, Elisabete Weiderpass, Katherine Marcelain, Mazda Jenab, Bettina Müller, Erik Morales, Pablo Baez Benavides, Krasimira Aleksandrova, G. Bedoya, Javier Retamales, Fernando Gabler, Armando Rojas, Dominique Scherer, Willem J R Bossers, Carol Barahona Ponce, Tahereh Moradi, Felix Boekstegers, Loreto Spencer, Uwe Völker, Kristian Hveem, Samuel Canizales, Verena Katzke, Giuliano Bernal, Rolando González-José, Hermann Brenner

Publikováno v: Cancer Epidemiology
Cancer Epidemiology, Elsevier, 2020, 65, pp.101643. ⟨10.1016/j.canep.2019.101643⟩
Cancer Epidemiol. 65:101643 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cancer Epidemiology, 2020, 65, pp.101643. ⟨10.1016/j.canep.2019.101643⟩

Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5229c10c10ef8a7ae6c15059ba532310
https://doi.org/10.1016/j.canep.2019.101643

Comparison of the composition of Pinus radiata bark extracts obtained at bench- and pilot-scales

Autor: Carlos Bocalandro, Ana María Gómez-Caravaca, Marlene Roeckel, Verónica Sanhueza, Maria Teresa Rodriguez-Estrada, Katherina Fernández, Julia González-Álvarez

Publikováno v: Industrial Crops and Products. 38:21-26

Pine bark represents an interesting byproduct from the forest that can be used as a source of antioxidants. To study the phenolic fraction of this matrix, Pinus radiata bark was extracted with a 75% ethanol solution at both bench- and pilot-scales fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c74309113b0a9659bee8389c2db0aef
https://doi.org/10.1016/j.indcrop.2012.01.001