A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis

Autor: Raquel López-Mejías, F. David Carmona, Santos Castañeda, Fernanda Genre, Sara Remuzgo-Martínez, Belén Sevilla-Perez, Norberto Ortego-Centeno, Javier Llorca, Begoña Ubilla, Verónica Mijares, Trinitario Pina, José A. Miranda-Filloy, Antonio Navas Parejo, Diego de Argila, Maximiliano Aragües, Esteban Rubio, Manuel León Luque, Juan María Blanco-Madrigal, Eva Galíndez-Aguirregoikoa, David Jayne, Ricardo Blanco, Javier Martín, Miguel A. González-Gay

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)

Abstract The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on the genetic component of this vasculitis we performed the first genome-wide association study (GWAS) on this condi

Externí odkaz: https://doaj.org/article/3e33d0a736e14f4593fe38919470b3d3

Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients.

Autor: Raquel López-Mejías, Fernanda Genre, Sara Remuzgo-Martínez, Montserrat Robustillo-Villarino, Mercedes García-Bermúdez, Javier Llorca, Alfonso Corrales, Carlos González-Juanatey, Begoña Ubilla, José A Miranda-Filloy, Verónica Mijares, Trinitario Pina, Ricardo Blanco, Juan J Alegre-Sancho, Marco A Ramírez Huaranga, María D Mínguez Sánchez, Beatriz Tejera Segura, Iván Ferraz-Amaro, Esther Vicente, F David Carmona, Santos Castañeda, Javier Martín, Miguel A González-Gay

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143153 (2015)

To determine whether the interleukin-33 (IL-33)-interleukin-1 receptor like 1 (IL-1RL1) signaling pathway is implicated in the risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA).A total of 576 Spanish RA patients from Nort

Externí odkaz: https://doaj.org/article/6cfa454a77df496396662cd37294b284

Influence of MUC5B gene on antisynthetase syndrome

Autor: Fernanda Hernandez-Gonzalez, Verónica Mijares, Leticia Lera-Gómez, Albert Selva-O'Callaghan, Julia Martínez-Barrio, Francisco Javier López-Longo, Sergio Prieto-González, Alicia De Pablo Gafas, Antonio Mera-Varela, Javier Narváez, Santos Castañeda, Ignacio Grafia, Jaime Calvo-Alén, María Aránzazu Alfranca González, Virginia Pérez, Gema Bonilla, Sonia María Fernández Rozas, Víctor Manuel Mora Cuesta, Nair Pérez Gómez, José M. Cifrián, Raquel López-Mejías, María Piedad Usetti, Miguel A. González-Gay, Olga Sánchez-Pernaute, Laura Nuño, Lorenzo Cavagna, Rosalía Laporta, Sara Remuzgo-Martínez, Fredeswinda Romero-Bueno, Verónica Pulito-Cueto, Oreste Gualillo, Ernesto Trallero-Araguás, Alejandro Balsa, Fernanda Genre, Javier Llorca, David Iturbe Fernández, Norberto Ortego-Centeno

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
Universidad de Cantabria (UC)
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports 10, Article number: 1415 (2020)
UCrea Repositorio Abierto de la Universidad de Cantabria
Scientific Reports
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Biblos-e Archivo. Repositorio Institucional de la UAM

MUC5B rs35705950 (G/T) is strongly associated with idiopathic pulmonary fibrosis (IPF) and also contributes to the risk of interstitial lung disease (ILD) in rheumatoid arthritis (RA-ILD) and chronic hypersensitivity pneumonitis (CHP). Due to this, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41132ba60a5884642515ac26fe437d7
http://hdl.handle.net/10810/43473

Significant sE-Selectin levels reduction after 6 months of anti-TNF-α therapy in non-diabetic patients with moderate-to-severe psoriasis

Autor: Miguel A. González-Gay, Susana Armesto, Javier Rueda-Gotor, Alfonso Corrales, Ricardo Blanco, Begoña Ubilla, Trinitario Pina, Raquel López-Mejías, Virginia Portilla, José L. Hernández, María Carmen González-Vela, José Luis Martín-Varillas, Verónica Mijares, Fernanda Genre, Javier Llorca, Trinidad Dierssen-Sotos, Marcos A. González-López, Sara Remuzgo-Martínez

Publikováno v: Journal of Dermatological Treatment. 28:726-730

Psoriasis patients have high risk of atherosclerosis, characterized by endothelial dysfunction. We aimed to study the association of the endothelial activation biomarkers monocyte chemoattractant protein 1 (MCP-1), soluble (s) E-selectin and P-select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3064608a646384392b8217cf31fe8fce
https://doi.org/10.1080/09546634.2017.1329498

FRI0006 PROTECTIVE ROLE OF THE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) RS2495477 POLYMORPHISM IN PATIENTS WITH RHEUMATOID ARTHRITIS AND SUBCLINICAL ATHEROSCLEROSIS

Autor: Iván Ferraz-Amaro, Santos Castañeda, Miguel A. González-Gay, Raquel López-Mejías, Oreste Gualillo, Ricardo Blanco, Verónica Mijares, Leticia Lera-Gómez, Fernanda Genre, Javier Llorca, Virginia Portilla, Alfonso Corrales, Sara Remuzgo-Martínez, Verónica Pulito-Cueto, Javier Ibáñez

Publikováno v: Poster Presentations.

Background RA is associated with the development of cardiovascular (CV) disease and subclinical atherosclerosis1. The presence of carotid plaques assessed by ultrasonography studies is a surrogate marker for subclinical atherosclerosis2. Proprotein c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11318488cd82e3cb4df55d313c15e7ff
https://doi.org/10.1136/annrheumdis-2019-eular.2383