Cobaltabis(Dicarbollide) [o-COSAN]− for Boron Neutron Capture Therapy of Head and Neck Cancer: Biodistribution and Irradiation Studies in an Experimental Oral Cancer Model

Autor: Mónica A. Palmieri, Andrea Monti Hughes, Verónica A. Trivillin, Marcela A. Garabalino, Paula S. Ramos, Silvia I. Thorp, Paula Curotto, Emiliano C. C. Pozzi, Miquel Nuez Martínez, Francesc Teixidor, Clara Viñas, Amanda E. Schwint

Publikováno v: Pharmaceuticals, Vol 17, Iss 10, p 1367 (2024)

Background: Boron neutron capture therapy (BNCT) is a tumor-selective particle radiotherapy that combines preferential boron accumulation in tumors and neutron irradiation. Based on previous studies in tumor-bearing mice, this study evaluated the bio

Externí odkaz: https://doaj.org/article/5a1d9bc41b604c8c87fb87d931f9357a

Enhanced Resolution of Neutron Autoradiography with UV-C Sensitization to Study Boron Microdistribution in Animal Models

Autor: Agustina Mariana Portu, María Sol Espain, Silvia Inés Thorp, Verónica Andrea Trivillin, Paula Curotto, Andrea Monti Hughes, Emiliano César Cayetano Pozzi, Marcela Alejandra Garabalino, Mónica Alejandra Palmieri, Pablo Nicolás Granell, Federico Golmar, Amanda Elena Schwint, Gisela Saint Martin

Publikováno v: Life, Vol 13, Iss 7, p 1578 (2023)

The assessment of boron microdistribution is essential to evaluate the suitability of boron neutron capture therapy (BNCT) in different biological models. In our laboratory, we have reported a methodology to produce cell imprints on polycarbonate thr

Externí odkaz: https://doaj.org/article/c7e1afdfcff041f5855c70ab03b7e6eb

Boron Neutron Capture Therapy (BNCT) Mediated by Maleimide-Functionalized Closo-Dodecaborate Albumin Conjugates (MID:BSA) for Oral Cancer: Biodistribution Studies and In Vivo BNCT in the Hamster Cheek Pouch Oral Cancer Model

Autor: Andrea Monti Hughes, Jessica A. Goldfinger, Mónica A. Palmieri, Paula Ramos, Iara S. Santa Cruz, Luciana De Leo, Marcela A. Garabalino, Silvia I. Thorp, Paula Curotto, Emiliano C. C. Pozzi, Kazuki Kawai, Shinichi Sato, María E. Itoiz, Verónica A. Trivillin, Juan S. Guidobono, Hiroyuki Nakamura, Amanda E. Schwint

Publikováno v: Life, Vol 12, Iss 7, p 1082 (2022)

Background: BNCT (Boron Neutron Capture Therapy) is a tumor-selective particle radiotherapy that combines preferential boron accumulation in tumors and neutron irradiation. Although p-boronophenylalanine (BPA) has been clinically used, new boron comp

Externí odkaz: https://doaj.org/article/e4a0381580454d8ea3d22c2ba6382e5e

Different oral cancer scenarios to personalize targeted therapy: Boron Neutron Capture Therapy translational studies

Autor: Andrea Monti Hughes, Amanda E. Schwint, Verónica A. Trivillin, S. Thorp, Romina F. Aromando, Maria E. Itoiz, Jessica A Goldfinger, Elisa M. Heber, P. Curotto, Emiliano Cc Pozzi, David W. Nigg, Mónica A. Palmieri, Iara S Santa Cruz, Marcela A. Garabalino, P.S. Ramos, Hanna Koivunoro

Publikováno v: Therapeutic Delivery. 10:353-362

Boron neutron capture therapy (BNCT) is a targeted therapy, which consists of preferential accumulation of boron carriers in tumor followed by neutron irradiation. Each oral cancer patient has different risks of developing one or more carcinomas and/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43421e31abe6e49fd76c028986da551
https://doi.org/10.4155/tde-2019-0022

Clinical Veterinary Boron Neutron Capture Therapy (BNCT) Studies in Dogs with Head and Neck Cancer: Bridging the Gap between Translational and Clinical Studies

Autor: Iara S Santa Cruz, Andrea Monti Hughes, Juan Longhino, S. Nievas, Paulina Oña, Hernan Costa, Marcela A. Garabalino, Andrea Leiras, Sergio Binia, María Silvina Olivera, Emiliano C. C. Pozzi, Lucas Provenzano, Paula Alessandrini, Gustavo A. Santa Cruz, Monica Rao, Esteban Boggio, Verónica A. Trivillin, Amanda E. Schwint, Marı́a de los Angeles Cantarelli, Fabricio Brollo, Sara J. González, Romina Ventimiglia

Publikováno v: Biology
Biology, Vol 9, Iss 327, p 327 (2020)
Volume 9
Issue 10
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Translational Boron Neutron Capture Therapy (BNCT) studies performed by our group and clinical BNCT studies worldwide have shown the therapeutic efficacy of BNCT for head and neck cancer. The present BNCT studies in veterinary patients with head and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49482796614bfc70d19c63998d10bf00
https://pubmed.ncbi.nlm.nih.gov/33036386