Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Venugopal, Pujari"'
Autor:
Anh T. Tran, Emma E. Watson, Venugopal Pujari, Trent Conroy, Luke J. Dowman, Andrew M. Giltrap, Angel Pang, Weng Ruh Wong, Roger G. Linington, Sebabrata Mahapatra, Jessica Saunders, Susan A. Charman, Nicholas P. West, Timothy D. H. Bugg, Julie Tod, Christopher G. Dowson, David I. Roper, Dean C. Crick, Warwick J. Britton, Richard J. Payne
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Drug resistant tuberculosis (TB) infections are emerging at a high rate, with only few therapeutic options currently available. Here, the authors report synthetic analogues of the natural product sansanmycin that target mycobacterial cell wall biosyn
Externí odkaz:
https://doaj.org/article/fa20939585404c08a152992a15e9084c
Autor:
Rakesh K Dhiman, Venugopal Pujari, James M Kincaid, Melanie A Ikeh, Tanya Parish, Dean C Crick
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214958 (2019)
The menaquinone biosynthetic pathway presents a promising drug target against Mycobacterium tuberculosis and potentially other Gram-positive pathogens. In the present study, the essentiality, steady state kinetics of MenA from M. tuberculosis and the
Externí odkaz:
https://doaj.org/article/d1e32ccd874444b0ba75e87523fc9b1d
Autor:
Elinor Hortle, David I. Roper, Warwick J. Britton, Richard J. Payne, Gregory M. Cook, Wendy Tran, Paige M. E. Hawkins, Alexander Stoye, Christopher G. Dowson, Rebecca E Audette, Thomas Balle, Jessica L. Ochoa, Gayathri Nagalingam, Daniel J Ford, Ali Saad Kusay, Venugopal Pujari, Roger G. Linington, Chen-Yi Cheung, Dean C. Crick, Eric J. Rubin, Stefan H. Oehlers, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:17326-17345
Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s
Publikováno v:
ACS infectious diseases. 8(12)
Menaquinone (MK) is an essential component of the electron transport chain (ETC) in the gram-variable
Autor:
Rebekah C Gullberg, J Jordan Steel, Venugopal Pujari, Joel Rovnak, Dean C Crick, Rushika Perera
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007261 (2018)
Positive strand RNA viruses, such as dengue virus type 2 (DENV2) expand and structurally alter ER membranes to optimize cellular communication pathways that promote viral replicative needs. These complex rearrangements require significant protein sca
Externí odkaz:
https://doaj.org/article/58b0218eb88849d8acb3e6cfaa98f604
Autor:
Kaja Berg, Pooja Hegde, Venugopal Pujari, Marzena Brinkmann, David Z. Wilkins, Tanya Parish, Dean C. Crick, Courtney C. Aldrich
Publikováno v:
SSRN Electronic Journal.
Autor:
Wendy, Tran, Ali S, Kusay, Paige M E, Hawkins, Chen-Yi, Cheung, Gayathri, Nagalingam, Venugopal, Pujari, Daniel J, Ford, Alexander, Stoye, Jessica L, Ochoa, Rebecca E, Audette, Elinor, Hortle, Stefan H, Oehlers, Susan A, Charman, Roger G, Linington, Eric J, Rubin, Christopher G, Dowson, David I, Roper, Dean C, Crick, Thomas, Balle, Gregory M, Cook, Warwick J, Britton, Richard J, Payne
Publikováno v:
Journal of medicinal chemistry. 64(23)
Herein, we report the design and synthesis of inhibitors of
Autor:
Melanie Ikeh, Dean C. Crick, Rakesh K. Dhiman, Venugopal Pujari, James M. Kincaid, Tanya Parish
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214958 (2019)
The menaquinone biosynthetic pathway presents a promising drug target against Mycobacterium tuberculosis and potentially other Gram-positive pathogens. In the present study, the essentiality, steady state kinetics of MenA from M. tuberculosis and the
Autor:
Venugopal Pujari, Dean C. Crick, J. Jordan Steel, Rebekah C. Gullberg, Joel Rovnak, Rushika Perera
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 8, p e1007261 (2018)
PLoS Pathogens, Vol 14, Iss 8, p e1007261 (2018)
Positive strand RNA viruses, such as dengue virus type 2 (DENV2) expand and structurally alter ER membranes to optimize cellular communication pathways that promote viral replicative needs. These complex rearrangements require significant protein sca
Autor:
Richard J. Payne, Anh Tran, Nicholas P. West, Timothy D. H. Bugg, Angel Pang, Dean C. Crick, David I. Roper, Trent Conroy, Sebabrata Mahapatra, Emma E. Watson, Jessica Saunders, Julie A. Tod, Andrew M. Giltrap, Christopher G. Dowson, Roger G. Linington, Luke J. Dowman, Weng Ruh Wong, Warwick J. Britton, Venugopal Pujari, Susan A. Charman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications
Nature Communications
Tuberculosis (TB) is responsible for enormous global morbidity and mortality, and current treatment regimens rely on the use of drugs that have been in use for more than 40 years. Owing to widespread resistance to these therapies, new drugs are despe