Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer.

Autor: Alsaiari SK; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Nadeef S; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Daristotle JL; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Rothwell W; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Du B; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Garcia J; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Zhang L; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Sarmadi M; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Forster TA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Menon N; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Lin SQ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Tostanoski LH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Hachmann N; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Wang EY; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Ventura JD; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Langer R; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Jaklenec A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Publikováno v: Science advances [Sci Adv] 2024 Mar 08; Vol. 10 (10), pp. eadj6380. Date of Electronic Publication: 2024 Mar 06.

Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants.

Autor: Fray EJ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: efray1@jhmi.edu., Wu F; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Simonetti FR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Zitzmann C; Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Sambaturu N; Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Molina-Paris C; Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Bender AM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Liu PT; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Ventura JD; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Wiseman RW; Wisconsin National Primate Research Center, Madison, WI 53715, USA., O'Connor DH; Wisconsin National Primate Research Center, Madison, WI 53715, USA., Geleziunas R; Gilead Sciences, Foster City, CA 94404, USA., Leitner T; Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Ribeiro RM; Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Perelson AS; Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Siliciano JD; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Siliciano RF; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21205, USA. Electronic address: rsiliciano@jhmi.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2023 Mar 08; Vol. 31 (3), pp. 356-372.e5. Date of Electronic Publication: 2023 Feb 20.

Rapid Loss of CD4 T Cells by Pyroptosis during Acute SIV Infection in Rhesus Macaques.

Autor: He X; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical School, Boston, Massachusetts, USA., Aid M; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical School, Boston, Massachusetts, USA., Ventura JD; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical School, Boston, Massachusetts, USA., Borducchi E; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical School, Boston, Massachusetts, USA., Lifton M; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical School, Boston, Massachusetts, USA., Liu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical School, Boston, Massachusetts, USA., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical School, Boston, Massachusetts, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.

Publikováno v: Journal of virology [J Virol] 2022 Sep 14; Vol. 96 (17), pp. e0080822. Date of Electronic Publication: 2022 Aug 24.

Therapeutic efficacy of an Ad26/MVA vaccine with SIV gp140 protein and vesatolimod in ART-suppressed rhesus macaques.

Autor: Ventura JD; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Nkolola JP; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Chandrashekar A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Borducchi EN; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Liu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Mercado NB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Hope DL; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Giffin VM; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., McMahan K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Geleziunas R; Gilead Sciences, Foster City, CA, 94404, USA., Murry JP; Gilead Sciences, Foster City, CA, 94404, USA., Yang Y; Gilead Sciences, Foster City, CA, 94404, USA., Lewis MG; Bioqual, Rockville, MD, 20852, USA., Pau MG; Janssen Infectious Diseases and Vaccines, 2301, Leiden, The Netherlands., Wegmann F; Janssen Infectious Diseases and Vaccines, 2301, Leiden, The Netherlands., Schuitemaker H; Janssen Infectious Diseases and Vaccines, 2301, Leiden, The Netherlands., Fray EJ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kumar MR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Siliciano JD; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Siliciano RF; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Robb ML; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA., Michael NL; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. dbarouch@bidmc.harvard.edu.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA. dbarouch@bidmc.harvard.edu.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2022 May 18; Vol. 7 (1), pp. 53. Date of Electronic Publication: 2022 May 18.

Comparable Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants.

Autor: Yu J; Beth Israel Deaconess Medical Center, Boston, MA, USA., Collier AY; Beth Israel Deaconess Medical Center, Boston, MA, USA., Rowe M; Beth Israel Deaconess Medical Center, Boston, MA, USA., Mardas F; Beth Israel Deaconess Medical Center, Boston, MA, USA., Ventura JD; Beth Israel Deaconess Medical Center, Boston, MA, USA., Wan H; Beth Israel Deaconess Medical Center, Boston, MA, USA., Miller J; Beth Israel Deaconess Medical Center, Boston, MA, USA., Powers O; Beth Israel Deaconess Medical Center, Boston, MA, USA., Chung B; Beth Israel Deaconess Medical Center, Boston, MA, USA., Siamatu M; Beth Israel Deaconess Medical Center, Boston, MA, USA., Hachmann NP; Beth Israel Deaconess Medical Center, Boston, MA, USA., Surve N; Beth Israel Deaconess Medical Center, Boston, MA, USA., Nampanya F; Beth Israel Deaconess Medical Center, Boston, MA, USA., Chandrashekar A; Beth Israel Deaconess Medical Center, Boston, MA, USA., Barouch DH; Beth Israel Deaconess Medical Center, Boston, MA, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2022 Feb 07. Date of Electronic Publication: 2022 Feb 07.