Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Venkita Subbulakshmi"'
Autor:
Vaishali Humnabadkar, Claire Sadler, Tanjore S. Balganesh, Prakash Vachaspati, Disha Awasthy, Manoranjan Panda, Mick D. Fellows, Parvinder Kaur, Stewart T. Cole, Florence Pojer, Vasan K. Sambandamurthy, João Neres, Sreevalli Sharma, V. Balasubramanian, Kannan Murugan, Meenakshi Mallya, Suresh Rudrapatna, Balachandra Bandodkar, Sudhir Landge, Bheemarao G. Ugarkar, Jyothi Mahadevaswamy, Kavitha Nagalapur, Amrita B. Mullick, Vasanthi Ramachandran, Anirban Ghosh, Venkita Subbulakshmi
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:7694-7710
We report the discovery of benzothiazoles, a novel anti-mycobacterial series, identified from a whole cell based screening campaign. Benzothiazoles exert their bactericidal activity against Mycobacterium tuberculosis (Mtb) through potent inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d84f5aa2e5195a52048dc8416022f28
https://doi.org/10.1016/j.bmc.2015.11.017
https://doi.org/10.1016/j.bmc.2015.11.017
Publikováno v:
Microbiology. 158:319-327
Alanine racemase (Alr) is an essential enzyme in most bacteria; however, some species (e.g. Listeria monocytogenes) can utilize d-amino acid transaminase (Dat) to generate d-alanine, which renders Alr non-essential. In addition to the conflicting rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6749cd8691564f5f0764df948456164
https://doi.org/10.1099/mic.0.054064-0
https://doi.org/10.1099/mic.0.054064-0
Autor:
Harini Iyer, Parvinder Kaur, R. Deepthi, Sreevalli Sharma, David Melnick, V. K. Ramya, Scott Butler, V. Balasubramanian, Meenakshi Balganesh, Lindsay Wright, Ambarish Ghosh, Vasan K. Sambandamurthy, Suresh Solapure, Venkita Subbulakshmi, Vasanthi Ramachandran
Treatment of tuberculosis (TB) is impaired by the long duration and complexity of therapy and the rising incidence of drug resistance. There is an urgent need for new agents with improved efficacy, safety, and compatibility with combination chemother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0283bd5dce42d4fec755db2f2907cc
https://europepmc.org/articles/PMC3910779/
https://europepmc.org/articles/PMC3910779/
Publikováno v:
Biochemical and Biophysical Research Communications. 250:15-21
Long-term treatment with 3-azido-3-deoxy thymidine (AZT) is often associated with myelosuppression. In AZT-treated Swiss mice, similar toxicological manifestations in terms of reduction of red blood and white blood cell counts and hemoglobin content
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3bdf84fcdc1fd7a5907ae7b7433bfe
https://doi.org/10.1006/bbrc.1998.9112
https://doi.org/10.1006/bbrc.1998.9112
Autor:
David Waterson, Vijender Panduga, Gajanan Shanbhag, Jim Werngren, Sheshagiri Gaonkar, Manjunatha R, Gulebahar Sheikh, Prashanti Madhavapeddi, Reetobrata Basu, Kakoli Mukherjee, Radha Shandil, Jitendar Reddy, Vrinda Nandi, Mahesh Kumar, Suresh Solapure, Venkita Subbulakshmi, Anirban Ghosh, Disha Awasthy, Praveena Manjrekar, Jon Read, Meenakshi Balganesh, Abhijeet Deshpande, Vaishali Humnabadkar, Anand Kumar V. Raichurkar, Sven Hoffner, Helen H.J. McMiken, Shahul Hameed P, Vasan K. Sambandamurthy, Sreevalli Sharma, Jayashree Puttur, Murugan Chinnapattu
Publikováno v:
Antimicrobial agents and chemotherapy. 58(1)
Moxifloxacin has shown excellent activity against drug-sensitive as well as drug-resistant tuberculosis (TB), thus confirming DNA gyrase as a clinically validated target for discovering novel anti-TB agents. We have identified novel inhibitors in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3838b3026ae087e6ad698e472c577027
https://pubmed.ncbi.nlm.nih.gov/24126580
https://pubmed.ncbi.nlm.nih.gov/24126580
Autor:
Umender Sharma, Venkita Subbulakshmi, Jyothi Bhat, Gulebahar Sheikh, Sudha Ravishankar, Anisha Ambady, Vasan K. Sambandamurthy, Kakoli Mukherjee, Disha Awasthy
Publikováno v:
Microbiology (Reading, England). 156(Pt 9)
Pantothenate kinase, an essential enzyme in bacteria and eukaryotes, is involved in catalysing the first step of conversion of pantothenate to coenzyme A (CoA). Three isoforms (type I, II and III) of this enzyme have been reported from various organi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097f085b1736bcc4db33ecf083a15653
https://pubmed.ncbi.nlm.nih.gov/20576686
https://pubmed.ncbi.nlm.nih.gov/20576686
Autor:
Sowmya Bharath, Disha Awasthy, Umender Sharma, Venkita Subbulakshmi, Sheshagiri Gaonkar, Nimi Marcel, Radha Shandil, Reena Yadav
Publikováno v:
Microbiology (Reading, England). 155(Pt 9)
Acetohydroxyacid synthase (AHAS) is the first enzyme in the branched-chain amino acid biosynthesis pathway in bacteria. Bioinformatics analysis revealed that theMycobacterium tuberculosisgenome contains four genes (ilvB1,ilvB2,ilvGandilvX) coding for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c6d14f742d49cd248bad3009d24bae
https://pubmed.ncbi.nlm.nih.gov/19542000
https://pubmed.ncbi.nlm.nih.gov/19542000
Autor:
Rozina Aamir, Venkita Subbulakshmi, Martha K. Cathcart, Claudine M. Oldfield, Crystal M. Weyman, Alan Wolfman, Qing Li
Publikováno v:
Cellular signalling. 19(2)
Phospholipases A(2) (PLA(2)) are potent regulators of the inflammatory response. We have observed that Group IV cPLA(2) activity is required for the production of superoxide anion (O(2)(-)) in human monocytes [Li Q., Cathcart M.K. J. Biol. Chem. 272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599db61a56f0d9119db042aa7a2b8109
https://pubmed.ncbi.nlm.nih.gov/16963226
https://pubmed.ncbi.nlm.nih.gov/16963226
Autor:
Ashish Bhattacharjee, Venkita Subbulakshmi, Martha K. Cathcart, Erik A. Bey, Frans B. Wientjes, Bo Xu, Gerald M. Feldman, Claudine M. Oldfield, Xiaoxian Zhao, Qing Li
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 173(9)
Our laboratory is interested in understanding the regulation of NADPH oxidase activity in human monocyte/macrophages. Protein kinase C (PKC) is reported to be involved in regulating the phosphorylation of NADPH oxidase components in human neutrophils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f8643dddf2948db40e167841d85437
https://pubmed.ncbi.nlm.nih.gov/15494525
https://pubmed.ncbi.nlm.nih.gov/15494525
Publikováno v:
The Journal of biological chemistry. 274(6)
Our previous studies have shown that human native low density lipoprotein (LDL) can be oxidized by activated human monocytes. In this process, both activation of protein kinase C (PKC) and induction of superoxide anion (O-2) production are required.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45281228d4c4ecc6449cffc68812af53
https://pubmed.ncbi.nlm.nih.gov/9920929
https://pubmed.ncbi.nlm.nih.gov/9920929