Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Venkatram Reddy Paidi"'
Autor:
Anne Rose, Qihong Zhao, Kumaravel Selvakumar, Percy H. Carter, Prakash Anjanappa, Jing Chen, Sandhya Mandlekar, Mary Ellen Cvijic, Andrew J. Tebben, Songmei Xu, Gregory D. Brown, Venkatram Reddy Paidi, Arvind Mathur, Douglas G. Batt, Jian Pang, Joel C. Barrish, Robert J. Cherney, Melissa Yarde, Ragini Vuppugalla
Publikováno v:
ACS Med Chem Lett
[Image: see text] BMS-813160 (compound 3) was identified as a potent and selective CCR2/5 dual antagonist. Compound 3 displayed good permeability at pH = 7.4 in PAMPA experiments and demonstrated excellent human liver microsome stability. Pharmacokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d0c6d25f05a8ec4cbd4e45bae9db09
https://doi.org/10.1021/acsmedchemlett.1c00373
https://doi.org/10.1021/acsmedchemlett.1c00373
Autor:
Joel C. Barrish, John Hynes, Ajay Saxena, Natesan Murugesan, Dianlin Xie, Anjaneya Chimalakonda, Stefan Ruepp, Mitalee Das, Richard Rampulla, Durgarao Kantheti, Chunhong Yan, Julie Carman, Jignesh Nagar, Siva Subramani, Qian Ruan, William J. Pitts, Rajeev S. Bhide, Paul A. Elzinga, Venkatram Reddy Paidi, John S. Sack, Mark Fereshteh, Thangavel Soodamani, Amrita Jha Mukherjee, T. Thanga Mariappan, Ramesh Kumar Sistla, Kaushik Ghosh, Debarati Mazumder, Kamalavenkatesh Palanisamy, Deborah A. Holloway, Susan E. Kiefer, John A. Newitt, Satheesh Kesavan Nair, Polimera Subba Rao, Shailesh Dudhgoankar, Percy H. Carter, Xin Li, Srinivas Maddi, S. Pon Saravanakumar, Sreekantha Ratna Kumar, Sucharita Bose
Publikováno v:
ACS Med Chem Lett
[Image: see text] IRAK4 is an attractive therapeutic target for the treatment of inflammatory conditions. Structure guided optimization of a nicotinamide series of inhibitors has been expanded to explore the IRAK4 front pocket. This has resulted in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bbdf7e3f4256a866250ac0c4fba45e
https://doi.org/10.1021/acsmedchemlett.0c00082
https://doi.org/10.1021/acsmedchemlett.0c00082
Autor:
Satheesh Nair, Sreekantha Ratna Kumar, Venkatram Reddy Paidi, Ramesh Sistla, Durgarao Kantheti, Subba Rao Polimera, Soodamani Thangavel, Amrita Jha Mukherjee, Mitalee Das, Bhide, Rajeev S., Pitts, William J., Natesan Murugesan, Shailesh Dudhgoankar, Jignesh Nagar, Siva Subramani, Debarati Mazumder, Carman, Julie A., Holloway, Deborah A., Xin Li, Fereshteh, Mark P.
Publikováno v:
ACS Medicinal Chemistry Letters; 7/9/2020, Vol. 11 Issue 7, p1402-1409, 8p