Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Venkateswarlu Yarlagadda"'
Autor:
Divakara S S M Uppu, Goutham B Manjunath, Venkateswarlu Yarlagadda, Jyothi E Kaviyil, Raju Ravikumar, Krishnamoorthy Paramanandham, Bibek R Shome, Jayanta Haldar
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0126757 (2015)
Gram-negative 'superbugs' such as New Delhi metallo-beta-lactamase-1 (blaNDM-1) producing pathogens have become world's major public health threats. Development of molecular strategies that can rehabilitate the 'old antibiotics' and halt the antibiot
Externí odkaz:
https://doaj.org/article/38adfd1742c640d09264ccf0d9c16558
Autor:
Divakara S S M Uppu, Goutham B Manjunath, Venkateswarlu Yarlagadda, Jyothi E Kaviyil, Raju Ravikumar, Krishnamoorthy Paramanandham, Bibek R Shome, Jayanta Haldar
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119422 (2015)
Gram-negative 'superbugs' such as New Delhi metallo-beta-lactamase-1 (blaNDM-1) producing pathogens have become world's major public health threats. Development of molecular strategies that can rehabilitate the 'old antibiotics' and halt the antibiot
Externí odkaz:
https://doaj.org/article/e93ac867485d472b910f2a93b310b621
Vancomycin Derivative Inactivates Carbapenem-Resistant Acinetobacter baumannii and Induces Autophagy
Autor:
Paramita Sarkar, Ravi Manjithaya, Jayanta Haldar, Grace Kaul, Sidharth Chopra, Veena Ammanathan, Sandip Samaddar, Venkateswarlu Yarlagadda, Chandradhish Ghosh, Manjulika Shukla
Publikováno v:
ACS Chemical Biology. 15:884-889
Vancomycin is a standard drug for the treatment of multidrug-resistant Gram-positive bacterial infections. Albeit, development of resistance (VRE, VRSA) and its inefficacy against persistent infections is a demerit. It is also intrinsically inactive
Publikováno v:
ACS infectious diseases. 7(6)
Increasing multidrug resistance in Neisseria gonorrheae is a growing public health crisis. Resistance to the last line therapies, cephalosporins and azithromycin, are of particular concern, fueling the need to discover new treatments. Here, we identi
Autor:
Venkateswarlu Yarlagadda, Georgina Cox, Timothy A. Johnson, Gerard D. Wright, Maulik N. Thaker, Ricardo Medina, Kalinka Koteva
Publikováno v:
ACS infectious diseases. 6(12)
The rise of bacterial antibiotic resistance coupled with a diminished antibiotic drug pipeline underlines the importance of developing rational strategies to discover new antimicrobials. Microbially derived natural products are the basis for most of
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Despite the remarkable advances due to the discovery and development of antimicrobials agents, infectious diseases remain the second leading cause of death worldwide. This fact underlines the importance of developing new therapeutic strategies to add
Publikováno v:
Cell Chem Biol
Aminoglycoside antibiotics require proton motive force (PMF) for bacterial internalization. In non-respiring populations, PMF drops below the level required for drug influx, limiting the utility of aminoglycosides against strict and facultative anaer
Publikováno v:
Journal of Global Antimicrobial Resistance. 5:71-74
Staphylococcus aureus is a facultative intracellular pathogen and there are limited options for the treatment of severe intracellular bacterial infections. The membrane-active glycopeptide antibiotic Van-QC8 is a permanent positively charged lipophil
Publikováno v:
Angewandte Chemie International Edition. 55:7836-7840
Vancomycin, the drug of last resort for Gram-positive bacterial infections, has also been rendered ineffective by the emergence of resistance in such bacteria. To combat the threat of vancomycin-resistant bacteria (VRB), we report the development of
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5477-5480
Antibiotic-resistant superbugs such as vancomycin-resistant Enterococci (VRE) and Staphylococci have become a major global health hazard. To address this issue, we synthesized vancomycin aglycon dimers to systematically probe the impact of a linker o