Zobrazeno 1 - 10
of 563
pro vyhledávání: '"Venkateshwari"'
Autor:
Moritz V. Warmbrunn, Ilias Attaye, Anthony Horak, Rakhee Banerjee, William J. Massey, Venkateshwari Varadharajan, Elena Rampanelli, Youling Hao, Sumita Dutta, Ina Nemet, Judith Aron-Wisnewsky, Karine Clément, Annefleur Koopen, Koen Wortelboer, Per-Olof Bergh, Mark Davids, Nadia Mohamed, E. Marleen Kemper, Stanley Hazen, Albert K. Groen, Daniel H. van Raalte, Hilde Herrema, Fredrik Backhed, J. Mark Brown, Max Nieuwdorp
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Imidazole Propionate (ImP), a gut-derived metabolite from histidine, affects insulin signaling in mice and is elevated in type 2 diabetes (T2D). However, the source of histidine and the role of the gut microbiota remain unclear. We conducted
Externí odkaz:
https://doaj.org/article/b22e925908314b35a5586a8bd491bf29
Publikováno v:
Middle East Fertility Society Journal, Vol 29, Iss 1, Pp 1-10 (2024)
Abstract Background Three or more consecutive pregnancy losses before the 20th week of gestation constitute recurrent pregnancy loss (RPL), and about half of these cases are still unsolved despite routine screening tests. The purpose of the current s
Externí odkaz:
https://doaj.org/article/7907901443174da1a3032426cc914269
Autor:
Venkateshwari Varadharajan, Iyappan Ramachandiran, William J Massey, Raghav Jain, Rakhee Banerjee, Anthony J Horak, Megan R McMullen, Emily Huang, Annette Bellar, Shuhui W Lorkowski, Kailash Gulshan, Robert N Helsley, Isabella James, Vai Pathak, Jaividhya Dasarathy, Nicole Welch, Srinivasan Dasarathy, David Streem, Ofer Reizes, Daniela S Allende, Jonathan D Smith, Judith Simcox, Laura E Nagy, J Mark Brown
Publikováno v:
eLife, Vol 12 (2024)
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver diseases. Specifically, the common MBOAT7 variant (rs641738) associated with reduced MBOAT7 ex
Externí odkaz:
https://doaj.org/article/3c5d86faa2f749f9b1ff225029440203
Autor:
Rakhee Banerjee, Rachel C. Hohe, Shijie Cao, Bryan M. Jung, Anthony J. Horak, Iyappan Ramachandiran, William J. Massey, Venkateshwari Varadharajan, Natalie I. Zajczenko, Amy C. Burrows, Sumita Dutta, Maryam Goudarzi, Kala Mahen, Abigail Carter, Robert N. Helsley, Scott M. Gordon, Richard E. Morton, Christopher Strauch, Belinda Willard, Camelia Baleanu Gogonea, Valentin Gogonea, Matteo Pedrelli, Paolo Parini, J. Mark Brown
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Introduction:The Aster-C protein (encoded by the Gramd1c gene) is an endoplasmic reticulum (ER) resident protein that has been reported to transport cholesterol from the plasma membrane to the ER. Although there is a clear role for the closely-relate
Externí odkaz:
https://doaj.org/article/a67ae9a7639840f1997cab8381632bbb
Autor:
Rakhee Banerjee, Chase J. Wehrle, Zeneng Wang, Jennifer D. Wilcox, Vinayak Uppin, Venkateshwari Varadharajan, Marko Mrdjen, Courtney Hershberger, Ofer Reizes, Jennifer S. Yu, Justin D. Lathia, Daniel M. Rotroff, Stanley L. Hazen, W. H. Wilson Tang, Federico Aucejo, J. Mark Brown
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1946 (2024)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. The gut microbiome has been implicated in outcomes for HCC, and gut microbe-derived products may serve as potential non-invasive indices for early HCC detection. Thi
Externí odkaz:
https://doaj.org/article/a62200dc1b60493abf45e69dac2752b1
Autor:
Mikala M. Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E. Mead, Zachary A. Kipp, Evelyn A. Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan R. Shelman, Harrison A. Clarke, Tara R. Hawkinson, Terrymar Medina, Ramon C. Sun, Todd A. Lydic, Terry D. Hinds, Jr., J. Mark Brown, Samir Softic, Gregory A. Graf, Robert N. Helsley
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101815- (2023)
Background and aims: Genome and epigenome wide association studies identified variants in carnitine palmitoyltransferase 1a (CPT1a) that associate with lipid traits. The goal of this study was to determine the role of liver-specific CPT1a on hepatic
Externí odkaz:
https://doaj.org/article/2e4f326f6761408c9020ccde9aaab299
Autor:
Vaishnavi V. Phadnis, Jamie Snider, Venkateshwari Varadharajan, Iyappan Ramachandiran, Amy A. Deik, Zon Weng Lai, Tenzin Kunchok, Elinor Ng Eaton, Carolin Sebastiany, Anna Lyakisheva, Kyle D. Vaccaro, Juliet Allen, Zhong Yao, Victoria Wong, Betty Geng, Kipp Weiskopf, Clary B. Clish, J. Mark Brown, Igor Stagljar, Robert A. Weinberg, Whitney S. Henry
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113023- (2023)
Summary: Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer. Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those containing the polyunsaturated fatty acid arachidonic acid (AA),
Externí odkaz:
https://doaj.org/article/f1a03612f457448787c70b44eca61b6d
Autor:
William J. Massey, Venkateshwari Varadharajan, Rakhee Banerjee, Amanda L. Brown, Anthony J. Horak, Rachel C. Hohe, Bryan M. Jung, Yunguang Qiu, E. Ricky Chan, Calvin Pan, Renliang Zhang, Daniela S. Allende, Belinda Willard, Feixiong Cheng, Aldons J. Lusis, J. Mark Brown
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 4, Pp 100349- (2023)
We previously demonstrated that antisense oligonucleotide-mediated knockdown of Mboat7, the gene encoding membrane bound O-acyltransferase 7, in the liver and adipose tissue of mice promoted high fat diet-induced hepatic steatosis, hyperinsulinemia,
Externí odkaz:
https://doaj.org/article/4c86927b018244dab52502931112ad14
Autor:
Sunitha Tella, Shehnaz Sultana, Sujatha Madireddy, Pratibha Nallari, Venkateshwari Ananthapur
Publikováno v:
Indian Journal of Dermatology, Vol 67, Iss 1, Pp 45-49 (2022)
Epidermolysis bullosa (EB) is a group of rare inherited conditions that results in blistering of the skin and mucous membranes. Mutations in the PLEC gene cause epidermolysis bullosa simplex (EBS). Mutations in type VII collagen, encoded by COL7A1 le
Externí odkaz:
https://doaj.org/article/4589e7971df648c89c6a186dedf8e80c
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 7, Pp 100234- (2022)
Advanced liver diseases account for approximately 2 million deaths annually worldwide. Roughly, half of liver disease-associated deaths arise from complications of cirrhosis and the other half driven by viral hepatitis and hepatocellular carcinoma. U
Externí odkaz:
https://doaj.org/article/48621b06f9fd46ffa7c6a1b5eb6ed874