Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Venkateshwar Mutyam"'
1
Akademický článek
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor: Jyoti Sharma, Ming Du, Eric Wong, Venkateshwar Mutyam, Yao Li, Jianguo Chen, Jamie Wangen, Kari Thrasher, Lianwu Fu, Ning Peng, Liping Tang, Kaimao Liu, Bini Mathew, Robert J. Bostwick, Corinne E. Augelli-Szafran, Hermann Bihler, Feng Liang, Jerome Mahiou, Josef Saltz, Andras Rab, Jeong Hong, Eric J. Sorscher, Eric M. Mendenhall, Candice J. Coppola, Kim M. Keeling, Rachel Green, Martin Mense, Mark J. Suto, Steven M. Rowe, David M. Bedwell
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination assoc
Externí odkaz: https://doaj.org/article/1010cb2b07ac42418e6fb9795f6fb27c
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2
Akademický článek
Endo-Porter–mediated delivery of phosphorodiamidate morpholino oligos (PMOs) in erythrocyte suspension cultures from Cope's gray treefrog Hyla chrysoscelis
Autor: Venkateshwar Mutyam, Matthew V. Puccetti, James Frisbie, David L. Goldstein, Carissa M. Krane
Publikováno v: BioTechniques, Vol 50, Iss 5, Pp 329-332 (2011)
Cope's gray treefrog, Hyla chrysoscelis, is a freeze-tolerant anuran that accumulates cryoprotective glycerol during cold acclimation. H. chrysoscelis erythrocytes express the aquaglyceroporin HC-3, which facilitates transmembrane glycerol and water
Externí odkaz: https://doaj.org/article/b52f428b3b47412094ad27b80510bcdd
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3
Antisense oligonucleotide-based drug development for Cystic Fibrosis patients carrying the 3849 + 10 kb C-to-T splicing mutation
Autor: Ofra Barchad-Avitzur, Yifat S. Oren, Liran Carmel, Venkateshwar Mutyam, Steve D. Wilton, Eric J. Sorscher, Isabelle Sermet-Gaudelus, A. Hatton, Efrat Ozeri-Galai, Steven M. Rowe, Yao Li, Batsheva Kerem, Joel Reiter, A. Golec, Eitan Kerem, Chen Leibson, Michal Irony-Tur Sinai, Jeong S. Hong
Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Background Antisense oligonucleotide (ASO)-based drugs for splicing modulation were recently approved for various genetic diseases with unmet need. Here we aimed to develop an ASO-based splicing modulation therapy for Cystic Fibrosis (CF) patients ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d35063a0e0b6ecd56a4c5828a2239c
http://europepmc.org/articles/PMC8464507
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4
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor: Ming Du, Ning Peng, Jamie R Wangen, Jianguo Chen, Rachel Green, Venkateshwar Mutyam, Yao Li, Kari Thrasher, Corinne E. Augelli-Szafran, Jerome Mahiou, Feng Liang, Jyoti Sharma, Lianwu Fu, Candice J. Coppola, Kim M. Keeling, Martin Mense, Eric M. Mendenhall, Jeong S. Hong, Hermann Bihler, Liping Tang, Robert Bostwick, Eric J. Sorscher, Bini Mathew, Josef Saltz, Steven M. Rowe, Andras Rab, Kaimao Liu, David M. Bedwell, Mark J. Suto, Eric Wong
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f418523dd1d2b9e08e9eb070c8ea0a14
https://doaj.org/article/1010cb2b07ac42418e6fb9795f6fb27c
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6
Novel Correctors and Potentiators Enhance Translational Readthrough in CFTR Nonsense Mutations
Autor: Jianguo Chen, Ashvani K. Singh, Yao Li, Katja Conrath, Jyoti Sharma, Emily Falk Libby, Li Ping Tang, Ning Peng, Steven M. Rowe, Venkateshwar Mutyam
Publikováno v: American Journal of Respiratory Cell and Molecular Biology
Am J Respir Cell Mol Biol
Premature-termination codons (PTCs) in CFTR (cystic fibrosis [CF] transmembrane conductance regulator) result in nonfunctional CFTR protein and are the proximate cause of ∼11% of CF-causing alleles, for which no treatments exist. The CFTR corrector
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b834e3264c71cea70c8d6d3340745e66
https://pubmed.ncbi.nlm.nih.gov/33705685
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8
Evaluation of a novel CFTR potentiator in COPD ferrets with acquired CFTR dysfunction
Autor: Niroop Kaza, Vivian Y. Lin, Denise Stanford, Shah S. Hussain, Emily Falk Libby, Harrison Kim, Monica Borgonovi, Katja Conrath, Venkateshwar Mutyam, Stephen A. Byzek, Li Ping Tang, John E. Trombley, Lawrence Rasmussen, Trenton Schoeb, Hui Min Leung, Guillermo J. Tearney, S. Vamsee Raju, Steven M. Rowe
Publikováno v: Eur Respir J
RationaleThe majority of chronic obstructive pulmonary disease (COPD) patients have chronic bronchitis, for which specific therapies are unavailable. Acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction is observed in chron
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b367ca79d9cb487c3dcf714048e05599
https://doi.org/10.1183/13993003.01581-2021
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9
Identification of the amino acids inserted during suppression of CFTR nonsense mutations and determination of their functional consequences
Autor: Venkateshwar Mutyam, Xiaojiao Xue, David M. Bedwell, Kim M. Keeling, Robert J. Bridges, Amita Thakerar, James A. Mobley, Steven M. Rowe
Publikováno v: Human molecular genetics. 26(16)
In-frame premature termination codons (PTCs) account for ∼11% of all disease-associated mutations. PTC suppression therapy utilizes small molecules that suppress translation termination at a PTC to restore synthesis of a full-length protein. PTC su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70dc12b04905a51c2f3126f892e2dde8
https://pubmed.ncbi.nlm.nih.gov/28575328
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10
Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations
Autor: Xiaojiao Xue, David M. Bedwell, Bo Liu, Kim M. Keeling, Martin Mense, Feng Liang, Emily Falk Libby, Marina Mazur, J. Robert Bostwick, Mark J. Suto, Haibo Shang, E. Lucile White, Venkateshwar Mutyam, Ming Du, Jeong S. Hong, Steven M. Rowe, Lynn Rasmussen
Publikováno v: American journal of respiratory and critical care medicine. 194(9)
Premature termination codons (PTCs) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). Several agents are known to suppress PTCs but are poorly efficacious or toxic.To determine whether there are clinic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b85c84689bbd73f1a99b916f360668
https://pubmed.ncbi.nlm.nih.gov/27797609
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