Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Venkatesh Sampath"'
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Necrotizing enterocolitis (NEC) remains a devastating disease in preterm and term neonates. Despite significant progress made in understanding NEC pathogenesis over the last 50 years, the inability of current definitions to discriminate the various p
Externí odkaz:
https://doaj.org/article/9d8762f98b904b5397194bab5d75685c
Autor:
Eric S. Geanes, Rebecca McLennan, Stephen H. Pierce, Heather L. Menden, Oishi Paul, Venkatesh Sampath, Todd Bradley
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109975- (2024)
Summary: Severe COVID-19 often leads to secondary infections and sepsis that contribute to long hospital stays and mortality. However, our understanding of the precise immune mechanisms driving severe complications after SARS-CoV-2 infection remains
Externí odkaz:
https://doaj.org/article/66359978581b4fd894b7c2cfb051929c
Autor:
Maribel Martinez, Wei Yu, Heather L. Menden, Tianhua Lei, Paula Monaghan-Nichols, Venkatesh Sampath
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundNecrotizing enterocolitis (NEC) is a devastating disease in premature infants, and 50% of infants with surgical NEC develop neurodevelopmental defects. The mechanisms by which NEC-induced cytokine release and activation of inflammatory cell
Externí odkaz:
https://doaj.org/article/3ea3e78240fd4dc9968a1c57eebac9cc
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
ObjectiveThis study investigates whether volumes of intake in the first 24 h of life (24 HOL), in relation to birth weight (BW) and gestational age (GA), impact neonatal feeding intolerance (FI).MethodsThis study employed a retrospective chart review
Externí odkaz:
https://doaj.org/article/c5e6326f19724783a579eff50060745d
Autor:
Megan H. Tucker, Wei Yu, Heather Menden, Sheng Xia, Carl F. Schreck, Margaret Gibson, Daniel Louiselle, Tomi Pastinen, Nikita Raje, Venkatesh Sampath
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Neonatal herpes simplex virus (HSV) infection is a devastating disease with substantial morbidity and mortality. The genetic basis of susceptibility to HSV in neonates remains undefined. We evaluated a male infant with neonatal skin/eye/mouth (SEM) H
Externí odkaz:
https://doaj.org/article/32b148b771ed4cf486ea79c96811dfcd
Publikováno v:
Cells, Vol 12, Iss 22, p 2648 (2023)
Endothelial cells are the crucial inner lining of blood vessels, which are pivotal in vascular homeostasis and integrity. However, these cells are perpetually subjected to a myriad of mechanical, chemical, and biological stresses that can compromise
Externí odkaz:
https://doaj.org/article/41d439108db94a099df16e00639f7d74
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
While prompt initiation of antibiotics at birth due to concerns for early onset sepsis is common, it often leads to many preterm infants being exposed to treatment despite negative blood cultures. Such exposure to early antibiotics can impact the dev
Externí odkaz:
https://doaj.org/article/9a0a6683c83a461e9b651a7949c944df
Publikováno v:
Cells, Vol 12, Iss 18, p 2231 (2023)
Angiogenesis plays a critical role in various physiological and pathological processes and is regulated by VEGF. Histone Deacetylase 6 (HDAC6) is a class IIB HDAC that regulates cytoplasmic signaling through deacetylation and is emerging as a target
Externí odkaz:
https://doaj.org/article/b7d5c19315b947f09b2fdcaed7a2e687
Autor:
Wei Yu, Inamul Haque, Aparna Venkatraman, Heather L. Menden, Sherry M. Mabry, Badal C. Roy, Sheng Xia, Jeremy W. Prokop, Shahid Umar, Aron M. Geurts, Venkatesh Sampath
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 425-440 (2022)
Background & Aims: Single immunoglobulin interleukin-1–related receptor (SIGIRR) is a major inhibitor of Toll-like receptor signaling. Our laboratory identified a novel SIGIRR stop mutation (p.Y168X) in an infant who died of severe necrotizing ente
Externí odkaz:
https://doaj.org/article/3e60b8ebab2c43c9848fc4805b58f9b2
Publikováno v:
Microorganisms, Vol 11, Iss 6, p 1482 (2023)
Peripartum antibiotics can negatively impact the developing gut microbiome and are associated with necrotizing enterocolitis (NEC). The mechanisms by which peripartum antibiotics increase the risk of NEC and strategies that can help mitigate this ris
Externí odkaz:
https://doaj.org/article/775ee0e02aa444df85f870cd58d492f9