Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Venkatesh Mallikarjun"'
Autor:
Hamish T. J. Gilbert, Venkatesh Mallikarjun, Oana Dobre, Mark R. Jackson, Robert Pedley, Andrew P. Gilmore, Stephen M. Richardson, Joe Swift
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cells must be robust to the mechanical demands of their environments. Here, Gilbert et al. expose cells to high-intensity strain cycling and use proteomics to identify a protein, SUN2, that behaves as a strain-induced breakpoint that can decouple the
Externí odkaz:
https://doaj.org/article/f8f759b44d8640cea035f511934e57db
Autor:
Jack Llewellyn, Venkatesh Mallikarjun, Ellen Appleton, Maria Osipova, Hamish T. J. Gilbert, Stephen M. Richardson, Simon J. Hubbard, Joe Swift
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Cells respond to stress by synthesizing chaperone proteins that seek to correct protein misfolding and maintain function. However, abrogation of protein homeostasis is a hallmark of aging, leading to loss of function and the formation of proteotoxic
Autor:
Venkatesh Mallikarjun, Oana Dobre, Mark R. Jackson, Melissa Kidd, Jack Llewellyn, Hamish T. J. Gilbert, Stephen M. Richardson, Joe Swift
Tissues are maintained by homeostatic feedback mechanisms where cells respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix. Mesenchymal stem cells (MSCs) resident in the marrow niche experience a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a541fb24c7632ac229665f3bfdd7321
https://doi.org/10.1101/2022.10.09.511462
https://doi.org/10.1101/2022.10.09.511462
Autor:
Ching-Yan Chloé Yeung, Richa Garva, Adam Pickard, Yinhui Lu, Venkatesh Mallikarjun, Joe Swift, Susan H. Taylor, Jyoti Rai, David R. Eyre, Mayank Chaturvedi, Yoshifumi Itoh, Qing-Jun Meng, Cornelia Mauch, Paola Zigrino, Karl E. Kadler
The circadian clock in tendon regulates the daily rhythmic synthesis of collagen-I and the appearance and disappearance of small-diameter collagen fibrils in the extracellular matrix. How the fibrils are assembled and removed is not fully understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c11c4ec59d00228e27e12fbca63f583f
https://doi.org/10.1101/2022.04.01.486699
https://doi.org/10.1101/2022.04.01.486699
Autor:
Venkatesh Mallikarjun, Dharshika Pathiranage, Qing-Jun Meng, John F. Bateman, Constanza Angelucci, Ping Wang, Shireen R. Lamandé, Judith A. Hoyland, Karl E. Kadler, Michal Dudek, Craig Lawless, Raymond P. Boot-Handford, Joe Swift
Publikováno v:
Osteoarthritis and Cartilage
Summary Objective Cartilage in joints such as the hip and knee experiences repeated phases of heavy loading and low load recovery during the 24-h day/night cycle. Our previous work has shown 24 h rhythmic changes in gene expression at transcript leve
Autor:
Antony Adamson, Joan Chang, David F. Holmes, Qing-Jun Meng, Joe Swift, Oliver E. Jensen, Ching-Yan Chloé Yeung, Adam Pickard, Venkatesh Mallikarjun, Karl E. Kadler, Tom Shearer, Ben Calverley, Helena Raymond-Hayling, Yinhui Lu, Richa Garva
Publikováno v:
Chang, J, Garva, R, Pickard, A, Yeung, C Y C, Mallikarjun, V, Swift, J, Holmes, D, Calverley, B, Lu, Y, Adamson, A, Raymond-Hayling, H, Jensen, O, Shearer, T, Meng, Q-J & Kadler, K 2020, ' Circadian control of the secretory pathway maintains collagen homeostasis ', Nature Cell Biology, vol. 22, no. 1, pp. 74-86 . https://doi.org/10.1038/s41556-019-0441-z
Collagen is the most abundant secreted protein in vertebrates and persists throughout life without renewal. The permanency of collagen networks contrasts with both the continued synthesis of collagen throughout adulthood and the conventional transcri
Autor:
Venkatesh Mallikarjun, Robert Pedley, Hamish T. J. Gilbert, Oana Dobre, Andrew P. Gilmore, Mark R. Jackson, Stephen M. Richardson, Joe Swift
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Gilbert, H, Mallikarjun, V, Dobre, O, Jackson, M, Pedley, R, Gilmore, A, Richardson, S & Swift, J 2019, ' Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading ', Nature Communications, vol. 10, 4149 . https://doi.org/10.1038/s41467-019-11923-1
Nature Communications
Gilbert, H, Mallikarjun, V, Dobre, O, Jackson, M, Pedley, R, Gilmore, A, Richardson, S & Swift, J 2019, ' Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading ', Nature Communications, vol. 10, 4149 . https://doi.org/10.1038/s41467-019-11923-1
Nature Communications
Studies of cellular mechano-signaling have often utilized static models that do not fully replicate the dynamics of living tissues. Here, we examine the time-dependent response of primary human mesenchymal stem cells (hMSCs) to cyclic tensile strain
Autor:
Kieran T. Mellody, Alexander Eckersley, Rachel E.B. Watson, Venkatesh Mallikarjun, Christopher E.M. Griffiths, David Knight, Michael J. Sherratt, Joe Swift, Ronan O’Cualain, Stacey Warwood, Matiss Ozols
Publikováno v:
Ozols, M, Eckersley, A, Mellody, K T, Mallikarjun, V, Warwood, S, O'Cualain, R, Knight, D, Watson, R E B, Griffiths, C E M, Swift, J & Sherratt, M J 2021, ' Peptide location fingerprinting reveals modification-associated biomarker candidates of ageing in human tissue proteomes ', Aging cell, vol. 20, no. 5, e13355 . https://doi.org/10.1111/acel.13355
Aging Cell
Aging Cell
Although dysfunctional protein homeostasis (proteostasis) is a key factor in many age‐related diseases, the untargeted identification of structurally modified proteins remains challenging. Peptide location fingerprinting is a proteomic analysis tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c82714f6c00920e57ea2685fd4c8aec
https://pure.manchester.ac.uk/ws/files/195412308/acel.13355.pdf
https://pure.manchester.ac.uk/ws/files/195412308/acel.13355.pdf
Autor:
Andrew P. Gilmore, Joe Swift, Louise E. King, Pengbo Wang, Keith Brennan, Venkatesh Mallikarjun, Robert Pedley
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 10, Pp 1-17 (2020)
Cell Death and Disease, Vol 11, Iss 10, Pp 1-17 (2020)
Apoptotic priming controls the commitment of cells to apoptosis by determining how close they lie to mitochondrial permeabilisation. Variations in priming are important for how both healthy and cancer cells respond to chemotherapeutic agents, but how
Autor:
Kieran T. Mellody, Alexander Eckersley, Stacey Warwood, Joe Swift, Ronan O’Cualain, Christopher E.M. Griffiths, Venkatesh Mallikarjun, Rachel E.B. Watson, Michael J. Sherratt, David Knight, Matiss Ozols
Although dysfunctional protein homeostasis (proteostasis) is a key factor in many age-related diseases, the untargeted identification of structural modifications in proteins remains challenging. Peptide location fingerprinting is a proteomic analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76948e02a25a8a00db5baac8221aa021
https://doi.org/10.1101/2020.09.14.296020
https://doi.org/10.1101/2020.09.14.296020