Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Venkatesh Kundumani-Sridharan"'
Autor:
Tieqiang Zhao, Dong Wang, Sergey Y. Cheranov, Manjula Karpurapu, Koteswara R. Chava, Venkatesh Kundumani-Sridharan, Dianna A. Johnson, John S. Penn, Gadiparthi N. Rao
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 521-533 (2009)
To investigate the mechanisms underlying 15(S)-HETE-induced angiogenesis, we have studied the role of the small GTPase, Rac1. We find that 15(S)-HETE activated Rac1 in human retinal microvascular endothelial cells (HRMVEC) in a time-dependent manner.
Externí odkaz:
https://doaj.org/article/0049af864d9f4afd89875af53021a393
Publikováno v:
Circulation Research. 129:930-945
Rationale: Nitric oxide (NO) produced by eNOS (endothelial NO synthase) protects against myocardial ischemia-reperfusion injury (I/R). However, reperfusion of myocardium results in superoxide (O 2 •− ) generation, which promotes eNOS glutathionyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63aa1a477f1bedc7262b2d9c78813e2
https://doi.org/10.1161/circresaha.120.317921
https://doi.org/10.1161/circresaha.120.317921
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Arterioscler Thromb Vasc Biol
Arterioscler Thromb Vasc Biol
Supplemental Digital Content is available in the text.
Objective: Remote ischemic preconditioning (RIPC) is an intervention process where the application of multiple cycles of short ischemia/reperfusion (I/R) in a remote vascular bed provides pr
Objective: Remote ischemic preconditioning (RIPC) is an intervention process where the application of multiple cycles of short ischemia/reperfusion (I/R) in a remote vascular bed provides pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee284ae58c762ab1453e0a25197b776
http://europepmc.org/articles/PMC8288485
http://europepmc.org/articles/PMC8288485
Publikováno v:
Aging. 12:19809-19827
Aging is an independent risk factor for cardiovascular diseases, such as myocardial infarction due to ischemia-reperfusion injury (I/R) of the heart. Cytosolic thioredoxin (Trx) is a multifunctional redox protein which has antioxidant and protein dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::416b0f87030dd0ee4e411fc643cf5536
https://doi.org/10.18632/aging.104071
https://doi.org/10.18632/aging.104071
Autor:
Somasundaram Raghavan, Venkatesh Kundumani-Sridharan, Sudhir Kumar, Carl W. White, Kumuda C. Das
Publikováno v:
Am J Respir Cell Mol Biol
Administration of high concentrations of oxygen (hyperoxia) is one of few available options to treat acute hypoxemia-related respiratory failure, as seen in the current coronavirus disease (COVID-19) pandemic. Although hyperoxia can cause acute lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d843960deb0b9765feecb152e7a984aa
https://europepmc.org/articles/PMC8937245/
https://europepmc.org/articles/PMC8937245/
Publikováno v:
Aging (Albany NY)
Aging is an independent risk factor for cardiovascular diseases, such as myocardial infarction due to ischemia-reperfusion injury (I/R) of the heart. Cytosolic thioredoxin (Trx) is a multifunctional redox protein which has antioxidant and protein dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7bb5718f474743c98403dbba57c321b8
https://pubmed.ncbi.nlm.nih.gov/33049718
https://pubmed.ncbi.nlm.nih.gov/33049718
Publikováno v:
Cardiovasc Toxicol
Cardiotoxicity is a major limitation for anthracycline chemotherapy although anthracyclines are potent antitumor agents. The precise mechanism underlying clinical heart failure due to anthracycline treatment is not fully understood, but is believed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4104cd6f41f12bc9d3f40b573219b8
https://pubmed.ncbi.nlm.nih.gov/32880787
https://pubmed.ncbi.nlm.nih.gov/32880787
Autor:
Guru P. Maiti, Steven Idell, Kumuda C. Das, Venkatesh Kundumani-Sridharan, Somasundaram Raghavan, Trevor Walker, John D. Wasnick, Jaganathan Subramani, Cade Owens
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
High concentrations of oxygen (hyperoxia) are routinely used during anesthesia, and supplemental oxygen is also administered in connection with several other clinical conditions. Although prolonged hyperoxia is known to cause acute lung injury (ALI),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5f7cf16843da6847d0cb5d5e47e0f7
https://pubmed.ncbi.nlm.nih.gov/30810065
https://pubmed.ncbi.nlm.nih.gov/30810065
Publikováno v:
Curr Hypertens Rep
PURPOSE OF REVIEW: Although the roles of oxidant stress and redox perturbations in hypertension have been the subject of several reviews, role of thioredoxin (Trx), a major cellular redox protein in age-related hypertension remains inadequately revie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a169bafea2069cd761bd8be076d6130
https://europepmc.org/articles/PMC7499340/
https://europepmc.org/articles/PMC7499340/
Publikováno v:
Journal of Biological Chemistry. 290:17505-17519
The mitogen-activated protein kinase kinase 4 (MKK4) is activated via phosphorylation of Ser-257 and Thr-261 by upstream MAP3Ks and activates JNK and p38 MAPKs in response to cellular stress. We show that thioredoxin (Trx), a cellular redox protein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ee2a3e803a9086d67b570eeeb97392
https://doi.org/10.1074/jbc.m115.660365
https://doi.org/10.1074/jbc.m115.660365