Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Venkatesh D. Handratta"'
Publikováno v:
Neurocase. 16:125-134
Chronic traumatic brain injury (CTBI) is associated with contact sports such as boxing. CTBI results from repetitive blows to the head rather than from a single impact. CTBI individuals present with motor symptoms (incoordination, spasticity, parkins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa955a0a10614f88fa8587bdd9eca88d
https://doi.org/10.1080/13554790903329166
https://doi.org/10.1080/13554790903329166
Autor:
Venkatesh D. Handratta, Jayesh Kamath
Publikováno v:
Expert Review of Neurotherapeutics. 8:1787-1797
Desvenlafaxine succinate (DVS) is the succinate salt monohydrate of O-desmethylvenlafaxine, an active metabolite of venlafaxine. DVS is a serotonin-norepinephrine reuptake inhibitor (SNRI) like venlafaxine, but exhibits a differential serotonergic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f14940c61db42c1e169a766d45f5070
https://doi.org/10.1586/14737175.8.12.1787
https://doi.org/10.1586/14737175.8.12.1787
Publikováno v:
Future Neurology. 2:361-371
Venlafaxine is a serotonin–norepinephrine-reuptake inhibitor (SNRI) with a well-established efficacy, safety and tolerability profile. Desvenlafaxine succinate is the succinate salt monohydrate of O-desmethylvenlafaxine, an active metabolite of ven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24bad6dbe78b3923cba6a1e609aa26d1
https://doi.org/10.2217/14796708.2.4.361
https://doi.org/10.2217/14796708.2.4.361
Autor:
Lalji K. Gediya, Vincent C. O. Njar, Rena Farquhar, Tadas S. Vasaitis, Ritesh Kataria, Yun Qiu, Pankaj Chopra, Zhiyong Guo, Angela Brodie, Donnell Newman, Venkatesh D. Handratta
Publikováno v:
Journal of Medicinal Chemistry. 48:2972-2984
New chemical entities, steroidal C-17 benzoazoles (5, 6, 9 and 10) and pyrazines (14 and 15) were rationally designed and synthesized. The key reaction for synthesis of the benzoazoles involved the nucleophilic vinylic "addition-elimination" substitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35aa62b014de5f7c069ec1993fe370c3
https://doi.org/10.1021/jm040202w
https://doi.org/10.1021/jm040202w
Autor:
Nicol Macpherson, Danijela Jelovac, Olga Goloubeva, Brian J. Long, Apinya Thiantanawat, Venkatesh D. Handratta, Joseph Ragaz, Angela Brodie
Publikováno v:
JNCI Journal of the National Cancer Institute. 96:456-465
Background: The antiestrogen tamoxifen has potent activity against estrogen receptor–positive breast cancer, but two nonsteroidal aromatase inhibitors, letrozole and anastrozole, show considerable advantages over tamoxifen with respect to patient s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c44fc5a0a1eafee2346a9d40c0e718
https://doi.org/10.1093/jnci/djh076
https://doi.org/10.1093/jnci/djh076
Publikováno v:
Medical hypotheses. 77(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9294d23d77952c0b79562f1cc5801c51
https://pubmed.ncbi.nlm.nih.gov/21664765
https://pubmed.ncbi.nlm.nih.gov/21664765
Publikováno v:
Cancer chemotherapy and pharmacology. 60(6)
Novel potent C-4 azolyl retinoic acid metabolism blocking agents (RAMBAs)-VN/14-1, VN/50-1, VN/66-1, VN/67-1, and VN/69-1, have been synthesized and investigated for their in vitro and in vivo effects against breast and prostate cancers. These RAMBAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfc1972e0176108270cf80186a0582a
https://pubmed.ncbi.nlm.nih.gov/17345084
https://pubmed.ncbi.nlm.nih.gov/17345084
Publikováno v:
Cancer research. 65(12)
Blocking estrogen receptors with antiestrogens and blocking estrogen synthesis with aromatase inhibitors are two strategies currently being used for reducing the effect of estrogen in postmenopausal estrogen receptor–positive breast cancer patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b092516e21bd3ae59aa7eda9584ea4d
https://pubmed.ncbi.nlm.nih.gov/15958593
https://pubmed.ncbi.nlm.nih.gov/15958593
Autor:
Angela Brodie, Olga Goloubeva, Jyoti Patel, Vincent C. O. Njar, Lalji K. Gediya, Carlic Huynh, Dianne Robert Soprano, Ivo P. Nanne, Venkatesh D. Handratta, Omoshile O. Clement
Publikováno v:
Journal of medicinal chemistry. 47(27)
Novel retinoic acid metabolism blocking agents (RAMBAs) have been synthesized and characterized. The synthetic features include introduction of nucleophilic ligands at C-4 of all-trans-retinoic acid (ATRA) and 13-cis-retinoic acid, and modification o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10aefd8f34d4d8412ae1d481fd7c2c4
https://pubmed.ncbi.nlm.nih.gov/15615521
https://pubmed.ncbi.nlm.nih.gov/15615521
Autor:
James N. Ingle, Luciana Macedo, Danijela Jelovac, Brian J. Long, Venkatesh D. Handratta, Angela M. H. Brodie, Olga Goloubeva
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 10(21)
Purpose: To optimize treatment strategies for postmenopausal breast cancer patients, we investigated the efficacy of the steroidal aromatase inhibitor exemestane alone or in combination with the antiestrogen tamoxifen in a xenograft model of postmeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f687efb809ff42fd139eb74476e8f5
https://pubmed.ncbi.nlm.nih.gov/15534114
https://pubmed.ncbi.nlm.nih.gov/15534114