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Autor:
Venkatesan Suryanarayanan, Kasi Pandima Devi, Tamilselvam Rajavel, Gunasekeran Banu Priya, Sanjeev Kumar Singh
Publikováno v:
European Journal of Pharmacology. 855:112-123
Daucosterol (DS) is a plant phytosterol which is shown to induce oxidative stress mediated apoptosis in various cancer cell lines. However, the molecular mechanism underlying its cellular action has not been documented against Non- Small Cell Lung Ca
Publikováno v:
International Journal of Biological Macromolecules. 120:823-834
p300/CBP Associated Factor (PCAF), a GNAT family member protein, represent a valid target for therapeutic interventions since its dysfunction has implicated in variety of diseases like cancer, diabetes, inflammatory diseases, etc. Despite its potenti
Autor:
Kasi Pandima Devi, Venkatesan Suryanarayanan, Mani Iyer Prasanth, Krishnaswamy Balamurugan, Dicson Sheeja Malar, Sanjeev Kumar Singh
Publikováno v:
Toxicology in Vitro. 50:160-171
Amyloid beta (Aβ) formation is one of the neuropathological hallmarks of Alzheimer's disease (AD), which induces the generation of reactive oxygen species (ROS), further leading to the alteration of several signalling pathways. In the present study,
Autor:
Sanjeev Kumar Singh, Kandasamy Ruckmani, Venkatesan Suryanarayanan, Pandian Packiyaraj, Tamilselvam Rajavel, Kasi Pandima Devi
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports
Scientific Reports
β-Sitosterol (BS), a major bioactive constituent present in plants and vegetables has shown potent anticancer effect against many human cancer cells, but the underlying mechanism remain elusive on NSCLC cancers. We found that BS significantly inhibi
Autor:
Sunita Yadav, Smita Gupta, Jitendra Kumar Saxena, Venkatesan Suryanarayanan, Sanjeev Kumar Singh
Publikováno v:
International Journal of Biological Macromolecules. 98:357-365
The present work deals with investigating the role of ionic interactions in the native conformation of BmGK by altering pH and salt concentration as well as by disruption of inter-subunit region. The study on structural and functional properties of B
Autor:
Sanjeev Kumar Singh, Chandrabose Selvaraj, Manikkam Rajalakshmi, Rajamanickam Pon Nivedha, Venkatesan Suryanarayanan
Publikováno v:
Medicinal Chemistry Research. 26:1915-1925
Prostate cancer is one of the frequently diagnosed cancers in men. In prostate cancer, initiation to the appearance of symptoms is a very long period. Due to its high latency period it paved the way for the chemoprevention. Chemopreventive drugs quic
Autor:
Smita Gupta, Venkatesan Suryanarayanan, Sanjeev Kumar Singh, Sunita Yadav, Jitendra Kumar Saxena
Publikováno v:
International Journal of Biological Macromolecules. 94:621-633
Guanylate kinase is one of the key enzymes in nucleotide biosynthesis. The study highlights the structural and functional properties of Brugia malayi Guanylate kinase (BmGK) in the presence of chemical denaturants. An inactive, partially unfolded, di
Autor:
Venkatesan Suryanarayanan, Vikash Kumar Dubey, Sanjeev Kumar Singh, Sitrarasu Vijaya Prabhu, Ruchika Bhardwaj, Shalini Singh
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 34:2367-2386
Targeting CAAX prenyl proteases of Leishmania donovani can be a good approach towards developing a drug molecule against Leishmaniasis. We have modeled the structure of CAAX prenyl protease I and II of L. donovani, using homology modeling approach. T
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1762
De novo design technique is complementary to high-throughput virtual screening and is believed to contribute in pharmaceutical development of novel drugs with desired properties at a very low cost and time-efficient manner. In this chapter, we outlin