Výsledky vyhledávání - "Venkataswamy Sorna"

Data Supplement from Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth

Autor: Stephen L. Lessnick, Sunil Sharma, Mary C. Beckerle, Venkataswamy Sorna, Laura M. Hoffman, Timothy Mulvihill, Jared Bearss, Emily R. Theisen, Savita Sankar

Supplementary materials, including supplementary Methods, Table S3. Primer Sequences. Figure S1. Transcriptional Profiling of HCI2509 in A673 and TTC-466. Figure S2. Morphological Changes in TTC-466 with HCI2509 Treatment. Figure S3. Effects of HCI25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1ad8f850da02fb8c808c3262e7b316
https://doi.org/10.1158/1078-0432.22456359.v1

Zobrazit plný text záznamu

Data from Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth

Autor: Stephen L. Lessnick, Sunil Sharma, Mary C. Beckerle, Venkataswamy Sorna, Laura M. Hoffman, Timothy Mulvihill, Jared Bearss, Emily R. Theisen, Savita Sankar

Purpose: Ewing sarcoma is a pediatric bone tumor that absolutely relies on the transcriptional activity of the EWS/ETS family of fusion oncoproteins. While the most common fusion, EWS/FLI, utilizes lysine-specific demethylase 1 (LSD1) to repress crit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5fae21fd235cba8af8bc20087297da
https://doi.org/10.1158/1078-0432.c.6523287.v1

Zobrazit plný text záznamu

Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors

Autor: Steven L. Warner, Sunil Sharma, Susie Choi, Kent J. Carpenter, Hariprasad Vankayalapati, Jared Bearss, David J. Bearss, Lee T. Call, Ting Chen, Venkataswamy Sorna

Publikováno v: Bioorganicmedicinal chemistry letters. 27(24)

In this work, we describe the use of the rule of 3 fragment-based strategies from biochemical screening data of 1100 in-house, small, low molecular weight fragments. The sequential combination of in silico fragment hopping and fragment linking based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50253488baf845235c44451ac258a4f8
https://pubmed.ncbi.nlm.nih.gov/29150397

Zobrazit plný text záznamu

High-Throughput Virtual Screening Identifies Novel N′-(1-Phenylethylidene)-benzohydrazides as Potent, Specific, and Reversible LSD1 Inhibitors

Autor: Sunil Sharma, Venkataswamy Sorna, Emily R. Theisen, Steven L. Warner, Bret Stephens, Hariprasad Vankayalapati, David J. Bearss

Publikováno v: Journal of Medicinal Chemistry. 56:9496-9508

Lysine specific demethylase 1 (LSD1) plays an important role in regulating histone lysine methylation at residues K4 and K9 on histone H3 and is an attractive therapeutic target in multiple malignancies. Here we report a structure-based virtual scree

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20702c3a5c80940ce6d7791eb6cf66b7
https://doi.org/10.1021/jm400870h

Zobrazit plný text záznamu

Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime β-Catenin Pathway Inhibitors

Autor: Marek W. Cholody, Kapil N. Bhalla, Anupam Verma, Glynn Weldon Gilcrease, Jared Bearss, Sunil Sharma, Janak Khimchand Padia, Stephen Horrigan, Hariprasad Vankayalapati, Raffaella Soldi, Venkataswamy Sorna

Publikováno v: Journal of medicinal chemistry. 58(15)

The Wnt/β-catenin signaling pathway plays a vital role in cell growth, the regulation, cell development, and the differentiation of normal stem cells. Constitutive activation of the Wnt/β-catenin signaling pathway is found in many human cancers, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfd54c9539401dd07d61659eb524197
https://pubmed.ncbi.nlm.nih.gov/26182238

Zobrazit plný text záznamu

Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma

Autor: Venkataswamy Sorna, Emily R. Theisen, Snehal Gajiwala, Sunil Sharma, Jared Bearss, Margit M. Janát-Amsbury

Publikováno v: BMC Cancer

Background Endometrial cancer is the most common gynecologic malignancy. Type II endometrial carcinoma is often poorly differentiated and patients diagnosed with Type II disease (~11%) are disproportionately represented in annual endometrial cancer d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3396ef8e3ef99914c18161f04f40a0
https://doi.org/10.1186/1471-2407-14-752

Zobrazit plný text záznamu

Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth

Autor: Timothy S. Mulvihill, Venkataswamy Sorna, Emily R. Theisen, Savita Sankar, Laura M. Hoffman, Sunil Sharma, Mary C. Beckerle, Stephen L. Lessnick, Jared Bearss

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 20(17)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0ff907396b738d299ec60c000c61b9
https://pubmed.ncbi.nlm.nih.gov/24963049

Zobrazit plný text záznamu

Synthesis and assessment of glycosaminoglycan priming activity of cluster-xylosides for potential use as proteoglycan mimetics

Autor: Vy M. Tran, Balagurunathan Kuberan, Venkataswamy Sorna, Duraikkannu Loganathan, Thao Kim Nu Nguyen

Publikováno v: ACS chemical biology. 8(5)

One of the distinct structural features of many proteoglycans (PGs) is the presence of two or more glycosaminoglycan (GAG) side chains covalently linked to a core protein. Previous studies have shown that the synergistic biological activity of multip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bcf0b419f07fc20f5ab5136e3c9480
https://pubmed.ncbi.nlm.nih.gov/23402705

Zobrazit plný text záznamu

Dimerized glycosaminoglycan chains increase FGF signaling during zebrafish development

Autor: Duraikkannu Loganathan, Lena Kjellén, Mamoru Koketsu, Akinori Kojima, Thao Kim Nu Nguyen, Chi Bin Chien, Venkataswamy Sorna, Richard I. Dorsky, Inger Eriksson, Vy M. Tran, Balagurunathan Kuberan

Publikováno v: IndraStra Global.

Proteoglycans (PGs) modulate numerous signaling pathways during development through binding of their glycosaminoglycan (GAG) side chains to various signaling molecules, including fibroblast growth factors (FGFs). A majority of PGs possess two or more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96dcca9a9c54f6e0f0b1e9253b1feaf5
https://igi.indrastra.com/items/show/81159

Zobrazit plný text záznamu

Abstract 3679: Inhibition of LSD1 disrupts global EWS/ETS transcriptional function in Ewing sarcoma

Autor: Timothy S. Mulvihill, Emily R. Theisen, Savita Sankar, Sunil Sharma, Venkataswamy Sorna, Stephen L. Lessnick, Jared Bearss

Publikováno v: Cancer Research. 74:3679-3679

Ewing sarcoma is an aggressive pediatric bone tumor characterized by an absolute reliance on the transcriptional activity of the EWS/ETS family of transcription factor fusion oncoproteins. The most common fusion is EWS/FLI, present in 85-95% of cases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c641811ef6807445204e6b245603124
https://doi.org/10.1158/1538-7445.am2014-3679

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání