Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Venkata S. Tayi"'
Publikováno v:
Glycosylation ISBN: 9781071616840
The N-glycosylation profile of a monoclonal antibody (mAb) is a critical quality attribute in relation to its therapeutic application. The control of this profile during biomanufacture is difficult because of the multiple parameters that affect the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd989d3643ffa9636c8198b3e3d6cc18
https://doi.org/10.1007/978-1-0716-1685-7_6
https://doi.org/10.1007/978-1-0716-1685-7_6
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2370
The N-glycosylation profile of a monoclonal antibody (mAb) is a critical quality attribute in relation to its therapeutic application. The control of this profile during biomanufacture is difficult because of the multiple parameters that affect the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb5c231a34c02d879fab4b1f5a759094
https://pubmed.ncbi.nlm.nih.gov/34611867
https://pubmed.ncbi.nlm.nih.gov/34611867
Publikováno v:
Journal of biotechnology. 333
The control of glycosylation profiles is essential to the consistent manufacture of therapeutic monoclonal antibodies that may be produced from a variety of cell lines including CHO and NS0. Of particular concern is the potential for generating non-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c95185acc5fdd6ff2e1609bf609b781
https://pubmed.ncbi.nlm.nih.gov/33901620
https://pubmed.ncbi.nlm.nih.gov/33901620
Autor:
Kyle W. Anderson, Christina Bergonzo, Kerry Scott, Ioannis L. Karageorgos, Elyssia S. Gallagher, Venkata S. Tayi, Michael Butler, Jeffrey W. Hudgens
Publikováno v:
Journal of Molecular Biology. 434:167391
Previous reports present different models for the stabilization of the Fc-FcγRI immune complex. Although accord exists on the importance of L235 in IgG1 and some hydrophobic contacts for complex stabilization, discord exists regarding the existence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3a618977b941671f524e80bc9270f5
https://doi.org/10.1016/j.jmb.2021.167391
https://doi.org/10.1016/j.jmb.2021.167391
Autor:
Rini Roy, Venkata S. Tayi, Andrey Giovanni Gomes de Oliveira, Michael Butler, Hélène Perreault, Céline Raymond, Yves Durocher, Edward Bodnar
Publikováno v:
Rapid Communications in Mass Spectrometry. 29:1817-1826
Rationale In the expression of recombinant proteins, an important parameter to control or influence is their level of sialylation. Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometric (MS) methods tend to either u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478bcfa29ee60d14079a4bf4495c1230
https://doi.org/10.1002/rcm.7287
https://doi.org/10.1002/rcm.7287
Autor:
Emy Komatsu, Edward Bodnar, Michael Butler, Maureen Spearman, Paul Lopez, Yann Zogbi, Andrey Giovanni Gomes de Oliveira, Venkata S. Tayi, Tristan Alexander Smythe, Thais Ferreira Nascimento, Rini Roy, Hélène Perreault, Lauren Girard
Publikováno v:
Canadian Journal of Chemistry. 93:754-763
The characterization of the N-glycan portion of antibodies has been the subject of several studies involving mass spectrometry. In this article, a workflow is presented that starts with the expression of a monoclonal antibody (EG2-hFc) in Chinese ham
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cde170b333bd0972f1df6d332c2d484
https://doi.org/10.1139/cjc-2015-0061
https://doi.org/10.1139/cjc-2015-0061
Publikováno v:
Biotechnology Journal. 10:1051-1066
Controlled feeding of glucose has been employed previously to enhance the productivity of recombinant glycoproteins but there is a concern that low concentrations of glucose could limit the synthesis of precursors of glycosylation. Here we investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4aa66117246c4b507bc04a00be055c
https://doi.org/10.1002/biot.201400662
https://doi.org/10.1002/biot.201400662
Autor:
Andrey Giovanni, Gomes de Oliveira, Rini, Roy, Céline, Raymond, Edward D, Bodnar, Venkata S, Tayi, Michael, Butler, Yves, Durocher, Hélène, Perreault
Publikováno v:
Rapid communications in mass spectrometry : RCM. 29(19)
In the expression of recombinant proteins, an important parameter to control or influence is their level of sialylation. Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometric (MS) methods tend to either underestima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00ec06d42c6eb410e7b10c634d7dc9b1
https://pubmed.ncbi.nlm.nih.gov/26331933
https://pubmed.ncbi.nlm.nih.gov/26331933
Autor:
Michael Butler, Venkata S. Tayi
Publikováno v:
Biotechnology Journal. 13:1700381
Antibodies are synthesized in mammalian cell culture as heterogeneous mixtures of glycoforms. Production of single glycoforms remains a challenge despite their value as therapeutics. The authors report a method of sequential enzymatic-based changes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ace6709deb1b8ac5eb464043bcd3da2
https://doi.org/10.1002/biot.201700381
https://doi.org/10.1002/biot.201700381
Autor:
Michael Butler, Venkata S. Tayi
Publikováno v:
Animal Cell Biotechnology: In Biologics Production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e75f731b1f103ee06649348f64a44cc3
https://doi.org/10.1515/9783110278965.301
https://doi.org/10.1515/9783110278965.301