Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Venkata S K Manem"'
Autor:
Philippe Joubert, Azadeh Arabzadeh, Valérie Breton, Mark Sorin, Elham Karimi, Morteza Rezanejad, Miranda W Yu, Lysanne Desharnais, Sheri A C McDowell, Samuel Doré, Benoit Fiset, Yuhong Wei, Roni Rayes, Michele Orain, Francois Coulombe, Venkata S K Manem, Andreanne Gagne, Daniela F Quail, Jonathan D Spicer, Logan A Walsh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Immunotherapy has revolutionized clinical outcomes for patients suffering from lung cancer, yet relatively few patients sustain long-term durable responses. Recent studies have demonstrated that the tumor immune microenvironment fosters tu
Externí odkaz:
https://doaj.org/article/b3889797f7b44bc4821c45531186df0a
Autor:
Venkata S. K. Manem
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Radiation therapy is among the most effective and commonly used therapeutic modalities of cancer treatments in current clinical practice. The fundamental paradigm that has guided radiotherapeutic regimens are ‘one-size-fits-all
Externí odkaz:
https://doaj.org/article/d155a7634a6f40b69fa5b4b3a08b043d
Autor:
Derek L. Clouthier, Scott C. Lien, S. Y. Cindy Yang, Linh T. Nguyen, Venkata S. K. Manem, Diana Gray, Michael Ryczko, Albiruni R. A. Razak, Jeremy Lewin, Stephanie Lheureux, Ilaria Colombo, Philippe L. Bedard, David Cescon, Anna Spreafico, Marcus O. Butler, Aaron R. Hansen, Raymond W. Jang, Sangeet Ghai, Ilan Weinreb, Valentin Sotov, Ramy Gadalla, Babak Noamani, Mengdi Guo, Sawako Elston, Amanda Giesler, Sevan Hakgor, Haiyan Jiang, Tracy McGaha, David G. Brooks, Benjamin Haibe-Kains, Trevor J. Pugh, Pamela S. Ohashi, Lillian L. Siu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Immune checkpoint inhibitors (ICIs) demonstrate unprecedented efficacy in multiple malignancies; however, the mechanisms of sensitivity and resistance are poorly understood and predictive biomarkers are scarce. INSPIRE is a phase
Externí odkaz:
https://doaj.org/article/31ba8dd2f028423db6db252c1c7723fb
Publikováno v:
Cancers
Volume 15
Issue 3
Pages: 670
Volume 15
Issue 3
Pages: 670
Background: Glioblastoma mortality is driven by tumour progression or recurrence despite administering a therapeutic arsenal consisting of surgical resection, radiation, and alkylating chemotherapy. The genetic changes underlying tumour progression a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a255f7e333d7fada67309a7d6cdd79
Autor:
Mark Sorin, Morteza Rezanejad, Elham Karimi, Benoit Fiset, Lysanne Desharnais, Lucas J. M. Perus, Simon Milette, Miranda W. Yu, Sarah M. Maritan, Samuel Doré, Émilie Pichette, William Enlow, Andréanne Gagné, Yuhong Wei, Michele Orain, Venkata S. K. Manem, Roni Rayes, Peter M. Siegel, Sophie Camilleri-Broët, Pierre Olivier Fiset, Patrice Desmeules, Jonathan D. Spicer, Daniela F. Quail, Philippe Joubert, Logan A. Walsh
We updated our data set, please use the new version (md5:e33079d5299cdc17f37b9f5e4c08be12). All data supporting the findings of the publication "Single-cell spatial landscapes of the lung tumour immune microenvironment", including masks of high-dimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8b7ab0452c8fa442f4dc9481d9cea7
Autor:
Sabine Elowe, Romain Villot, Yohan Bossé, Stéphane Gobeil, Mathieu Laplante, Inan Bakan, Venkata S. K. Manem, Frédérick A. Mallette, Danielle Caron, Jean-Christophe Bérubé, Steve Bilodeau, Romain Devillers, Yves Gélinas, Yan Coulombe, Laura Tribouillard, Jean-Sébastien Bérubé, Éma Duchesne, Jean-Yves Masson, Michèle Orain, Erlinda Fernández, Luciano Gama-Braga, Audrey Poirier, Karine Boulay, Andréanne Gagné, Philippe Joubert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
RAS proteins are GTPases that lie upstream of a signaling network impacting cell fate determination. How cells integrate RAS activity to balance proliferation and cellular senescence is still incompletely characterized. Here, we identify ZNF768 as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d12920290f2df31a87a5119c8e325c9
https://doaj.org/article/8280dad19e4949b787cc212a7dfd3068
https://doaj.org/article/8280dad19e4949b787cc212a7dfd3068
Autor:
Babak Khoshkrood Mansoori, Philippe Joubert, Venkata S. K. Manem, Philippe Laflamme, Sylvain Trahan, Michèle Orain, Serge Simard, Olga Sazanova, Christian Couture
Publikováno v:
Human Pathology. 106:74-81
Summary Lung carcinoid tumors are classified as either typical or atypical based on the presence of necrosis and the maximum mitotic count per 2 mm2 area. Determining the mitotic count, which is manually conducted on slides stained with hematoxylin a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721db9fdc637276f8721f3b716c749bc
https://doi.org/10.1016/j.humpath.2020.09.009
https://doi.org/10.1016/j.humpath.2020.09.009
Autor:
Romain Villot, Audrey Poirier, Romain Devillers, Aliona Kolnoguz, Sabine Elowe, Venkata S. K. Manem, Philippe Joubert, Frédérick A. Mallette, Mathieu Laplante
Publikováno v:
Molecularcellular oncology. 8(6)
We recently identified Zinc-finger protein 768 (ZNF768) as a novel transcription factor controlling cell fate decision downstream of Rat sarcoma virus (RAS). We showed that ZNF768 depletion impairs cell cycle progression and triggers cellular senesce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e531d9f4ebd7fbdff71e2a8f325b1310
https://pubmed.ncbi.nlm.nih.gov/35419475
https://pubmed.ncbi.nlm.nih.gov/35419475
Autor:
Michèle Orain, Babak Khoshkrood-Mansoori, Nathalie Gaudreault, Yohan Bossé, Patrice Desmeules, Philippe Joubert, Venkata S. K. Manem, Olga V. Sazonova
Publikováno v:
Modern Pathology. 33:1712-1721
Pulmonary neuroendocrine neoplasms are classified by WHO as either typical or atypical carcinoids, large cell (LCNEC) or small cell (SCLC) neuroendocrine carcinoma based on mitotic count, morphology, and necrosis assessment. LCNEC with low mitotic co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101640c719cc7e9c51649d798d5704b2
https://doi.org/10.1038/s41379-020-0538-8
https://doi.org/10.1038/s41379-020-0538-8
Autor:
Mark Sorin, Elham Karimi, Morteza Rezanejad, Miranda W Yu, Lysanne Desharnais, Sheri A C McDowell, Samuel Doré, Azadeh Arabzadeh, Valerie Breton, Benoit Fiset, Yuhong Wei, Roni Rayes, Michele Orain, Francois Coulombe, Venkata S K Manem, Andreanne Gagne, Daniela F Quail, Philippe Joubert, Jonathan D Spicer, Logan A Walsh
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e005545
BackgroundImmunotherapy has revolutionized clinical outcomes for patients suffering from lung cancer, yet relatively few patients sustain long-term durable responses. Recent studies have demonstrated that the tumor immune microenvironment fosters tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b193b335f8aa56b87c42912ab9cd5829
https://doi.org/10.1136/jitc-2022-005545
https://doi.org/10.1136/jitc-2022-005545