Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Venkata S K Manem"'
Publikováno v:
Cancer Medicine, Vol 13, Iss 20, Pp n/a-n/a (2024)
ABSTRACT Objective Lung cancer remains the leading cause of cancer‐related mortality worldwide, with most cases diagnosed at advanced stages. Hence, there is a need to develop effective predictive models for early detection. This study aims to inve
Externí odkaz:
https://doaj.org/article/30638309cfd540339fba3bd91d3e3544
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Although substantial efforts have been made to build molecular biomarkers to predict radiation sensitivity, the ability to accurately stratify the patients is still limited. In this study, we aim to leverage large-scale radiogenom
Externí odkaz:
https://doaj.org/article/7784e6f2a2db4c85bac99cf3f2fde13b
Autor:
Sevinj Yolchuyeva, Elena Giacomazzi, Marion Tonneau, Fabien Lamaze, Michele Orain, François Coulombe, Julie Malo, Wiam Belkaid, Bertrand Routy, Philippe Joubert, Venkata S. K. Manem
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract With the increasing use of immune checkpoint inhibitors (ICIs), there is an urgent need to identify biomarkers to stratify responders and non-responders using programmed death-ligand (PD-L1) expression, and to predict patient-specific outcom
Externí odkaz:
https://doaj.org/article/fd7837095cb744958b685f0602f90ba3
Autor:
Marion Tonneau, Kim Phan, Venkata S. K. Manem, Cecile Low-Kam, Francis Dutil, Suzanne Kazandjian, Davy Vanderweyen, Justin Panasci, Julie Malo, François Coulombe, Andréanne Gagné, Arielle Elkrief, Wiam Belkaïd, Lisa Di Jorio, Michele Orain, Nicole Bouchard, Thierry Muanza, Frank J. Rybicki, Kam Kafi, David Huntsman, Philippe Joubert, Florent Chandelier, Bertrand Routy
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundRecent developments in artificial intelligence suggest that radiomics may represent a promising non-invasive biomarker to predict response to immune checkpoint inhibitors (ICIs). Nevertheless, validation of radiomics algorithms in independe
Externí odkaz:
https://doaj.org/article/1c9b27366e80483d88227a18e19ca975
Autor:
Philippe Joubert, Azadeh Arabzadeh, Valérie Breton, Mark Sorin, Elham Karimi, Morteza Rezanejad, Miranda W Yu, Lysanne Desharnais, Sheri A C McDowell, Samuel Doré, Benoit Fiset, Yuhong Wei, Roni Rayes, Michele Orain, Francois Coulombe, Venkata S K Manem, Andreanne Gagne, Daniela F Quail, Jonathan D Spicer, Logan A Walsh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Immunotherapy has revolutionized clinical outcomes for patients suffering from lung cancer, yet relatively few patients sustain long-term durable responses. Recent studies have demonstrated that the tumor immune microenvironment fosters tu
Externí odkaz:
https://doaj.org/article/b3889797f7b44bc4821c45531186df0a
Autor:
Venkata S. K. Manem
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Radiation therapy is among the most effective and commonly used therapeutic modalities of cancer treatments in current clinical practice. The fundamental paradigm that has guided radiotherapeutic regimens are ‘one-size-fits-all
Externí odkaz:
https://doaj.org/article/d155a7634a6f40b69fa5b4b3a08b043d
Autor:
Romain Villot, Audrey Poirier, Romain Devillers, Aliona Kolnoguz, Sabine Elowe, Venkata S. K. Manem, Philippe Joubert, Frédérick A. Mallette, Mathieu Laplante
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
We recently identified Zinc-finger protein 768 (ZNF768) as a novel transcription factor controlling cell fate decision downstream of Rat sarcoma virus (RAS). We showed that ZNF768 depletion impairs cell cycle progression and triggers cellular senesce
Externí odkaz:
https://doaj.org/article/db47c44d8e2b471cb74cfa54f7427180
Autor:
Derek L. Clouthier, Scott C. Lien, S. Y. Cindy Yang, Linh T. Nguyen, Venkata S. K. Manem, Diana Gray, Michael Ryczko, Albiruni R. A. Razak, Jeremy Lewin, Stephanie Lheureux, Ilaria Colombo, Philippe L. Bedard, David Cescon, Anna Spreafico, Marcus O. Butler, Aaron R. Hansen, Raymond W. Jang, Sangeet Ghai, Ilan Weinreb, Valentin Sotov, Ramy Gadalla, Babak Noamani, Mengdi Guo, Sawako Elston, Amanda Giesler, Sevan Hakgor, Haiyan Jiang, Tracy McGaha, David G. Brooks, Benjamin Haibe-Kains, Trevor J. Pugh, Pamela S. Ohashi, Lillian L. Siu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Immune checkpoint inhibitors (ICIs) demonstrate unprecedented efficacy in multiple malignancies; however, the mechanisms of sensitivity and resistance are poorly understood and predictive biomarkers are scarce. INSPIRE is a phase
Externí odkaz:
https://doaj.org/article/31ba8dd2f028423db6db252c1c7723fb
Publikováno v:
Cancers
Volume 15
Issue 3
Pages: 670
Volume 15
Issue 3
Pages: 670
Background: Glioblastoma mortality is driven by tumour progression or recurrence despite administering a therapeutic arsenal consisting of surgical resection, radiation, and alkylating chemotherapy. The genetic changes underlying tumour progression a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a255f7e333d7fada67309a7d6cdd79
Autor:
Mark Sorin, Morteza Rezanejad, Elham Karimi, Benoit Fiset, Lysanne Desharnais, Lucas J. M. Perus, Simon Milette, Miranda W. Yu, Sarah M. Maritan, Samuel Doré, Émilie Pichette, William Enlow, Andréanne Gagné, Yuhong Wei, Michele Orain, Venkata S. K. Manem, Roni Rayes, Peter M. Siegel, Sophie Camilleri-Broët, Pierre Olivier Fiset, Patrice Desmeules, Jonathan D. Spicer, Daniela F. Quail, Philippe Joubert, Logan A. Walsh
We updated our data set, please use the new version (md5:e33079d5299cdc17f37b9f5e4c08be12). All data supporting the findings of the publication "Single-cell spatial landscapes of the lung tumour immune microenvironment", including masks of high-dimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8b7ab0452c8fa442f4dc9481d9cea7
