Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Venkata R. P. Ratnala"'
Autor:
Brian K. Kobilka, Daniel M. Rosenbaum, Tong Sun Kobilka, Søren G. F. Rasmussen, Gebhard F. X. Schertler, Robert F. Fischetti, William I. Weis, Manfred Burghammer, Foon Sun Thian, Venkata R. P. Ratnala, Hee Jung Choi, Ruslan Sanishvili, Patricia C. Edwards
Publikováno v:
Nature. 450:383-387
Structural analysis of G-protein-coupled receptors (GPCRs) for hormones and neurotransmitters has been hindered by their low natural abundance, inherent structural flexibility, and instability in detergent solutions. Here we report a structure of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa715cfd413cc23c58b8a620c53e0e56
https://doi.org/10.1038/nature06325
https://doi.org/10.1038/nature06325
Autor:
Seébastien Granier, Venkata R. P. Ratnala, Samuel Kim, Richard N. Zare, Brian K. Kobilka, Aaron M. Shafer, Juan Joseé Fung
Publikováno v:
Journal of Biological Chemistry. 282:13895-13905
The C terminus of the beta(2)-adrenoceptor (AR) interacts with G protein-coupled receptor kinases and arrestins in an agonist-dependent manner, suggesting that conformational changes induced by ligands in the transmembrane domains are transmitted to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::786ff1a2eb01f3021af824416210ff43
https://doi.org/10.1074/jbc.m611904200
https://doi.org/10.1074/jbc.m611904200
Autor:
Venkata R. P. Ratnala, Gayathri Swaminath, David L. Farrens, Charles Parnot, Brian K. Kobilka, Xiao-Jie Yao, Xavier Deupi
Publikováno v:
Nature Chemical Biology. 2:417-422
G protein-coupled receptors (GPCRs) regulate a wide variety of physiological functions in response to structurally diverse ligands ranging from cations and small organic molecules to peptides and glycoproteins. For many GPCRs, structurally related li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1798230fa8a774c2aa1c02f36dee1a6d
https://doi.org/10.1038/nchembio801
https://doi.org/10.1038/nchembio801
Autor:
Venkata R. P. Ratnala
Publikováno v:
Biotechnology Letters. 28:767-778
Biotechnology using molecular biology, biochemistry, biophysics, and computational approaches provides an alternative approach for classical pharmacological screening to look at ligand-receptor interactions and receptor specificity, which should supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cf850a9c792abb601f035b09ec2345
https://doi.org/10.1007/s10529-006-9005-y
https://doi.org/10.1007/s10529-006-9005-y
Autor:
Herman G. P. Swarts, Jenny VanOostrum, Venkata R. P. Ratnala, Remko A. Bakker, Rob Leurs, Willem J. DeGrip, Huub J. M. DeGroot
Publikováno v:
European Journal of Biochemistry. 271:2636-2646
This report describes an efficient strategy for amplified functional purification of the human H1 receptor after heterologous expression in Sf9 cells. The cDNA encoding a C-terminally histidine-tagged (10xHis) human histamine H1 receptor was used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c57080f0826c16769a4d8e524988baf
https://doi.org/10.1111/j.1432-1033.2004.04192.x
https://doi.org/10.1111/j.1432-1033.2004.04192.x
Autor:
Venkata R P, Ratnala, Brian, Kobilka
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 552
Understanding the ternary complex between G protein-coupled receptors (GPCRs), cognate G proteins, and their ligands is an important landmark for drug discovery. Yet, little is known about the specific interactions between GPCRs and G proteins. For a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9178b5e272e5ac01f4fdff17d3393ac6
https://pubmed.ncbi.nlm.nih.gov/19513642
https://pubmed.ncbi.nlm.nih.gov/19513642
Publikováno v:
Methods in Molecular Biology ISBN: 9781603273169
Understanding the ternary complex between G protein-coupled receptors (GPCRs), cognate G proteins, and their ligands is an important landmark for drug discovery. Yet, little is known about the specific interactions between GPCRs and G proteins. For a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7468996a7baffaf79932156f6a954ad
https://doi.org/10.1007/978-1-60327-317-6_5
https://doi.org/10.1007/978-1-60327-317-6_5
Autor:
Patricia C. Edwards, Venkata R. P. Ratnala, Manfred Burghammer, Michael A. Hanson, Foon Sun Thian, Raymond C. Stevens, Brian K. Kobilka, William I. Weis, Vadim Cherezov, Asna Masood, Peter Day, Peter Kuhn, Ruslan Sanishvili, Hee Jung Choi, Juan Jose Fung, Xiao Jie Yao, Søren G. F. Rasmussen, Gebhard F. X. Schertler, Robert F. Fischetti, Daniel K. Rohrer, Tong Sun Kobilka, Daniel M. Rosenbaum, Charles Parnot
Publikováno v:
NATO Science for Peace and Security Series A: Chemistry and Biology ISBN: 9789048123384
G protein coupled receptors (GPCRs) constitute the largest family of membrane proteins in the human genome, and are responsible for the majority of signal transduction events involving hormones and neuro-transmitters across the cell membrane. GPCRs t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e3427a92ca157ae157a70fc5b91a288
https://doi.org/10.1007/978-90-481-2339-1_14
https://doi.org/10.1007/978-90-481-2339-1_14
Autor:
Sébastien, Granier, Samuel, Kim, Aaron M, Shafer, Venkata R P, Ratnala, Juan José, Fung, Richard N, Zare, Brian, Kobilka
Publikováno v:
The Journal of biological chemistry. 282(18)
The C terminus of the beta(2)-adrenoceptor (AR) interacts with G protein-coupled receptor kinases and arrestins in an agonist-dependent manner, suggesting that conformational changes induced by ligands in the transmembrane domains are transmitted to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58d71abb68f0a00158b7aa110ce3ef5d
https://pubmed.ncbi.nlm.nih.gov/17347144
https://pubmed.ncbi.nlm.nih.gov/17347144
Autor:
Rob Leurs, Venkata R. P. Ratnala, Willem J. DeGrip, Huub J. M. de Groot, Suzanne Kiihne, Francesco Buda
Publikováno v:
Journal of the American Chemical Society, 129(4), 867-872
Journal of the American Chemical Society, 129, 867-72
Ratnala, V R, Kiihne, S R, Buda, F, Leurs, R, de Groot, H & DeGrip, W J 2007, ' Solid-state NMR evidence for a protonation switch in the binding pocket of the H1 receptor upon binding of the agonist histamine ', Journal of the American Chemical Society, vol. 129, no. 4, pp. 867-72 . https://doi.org/10.1021/ja0652262
Journal of the American Chemical Society, 129, 4, pp. 867-72
Journal of the American Chemical Society, 129(4), 867-72. American Chemical Society
Journal of the American Chemical Society, 129, 867-72
Ratnala, V R, Kiihne, S R, Buda, F, Leurs, R, de Groot, H & DeGrip, W J 2007, ' Solid-state NMR evidence for a protonation switch in the binding pocket of the H1 receptor upon binding of the agonist histamine ', Journal of the American Chemical Society, vol. 129, no. 4, pp. 867-72 . https://doi.org/10.1021/ja0652262
Journal of the American Chemical Society, 129, 4, pp. 867-72
Journal of the American Chemical Society, 129(4), 867-72. American Chemical Society
Contains fulltext : 52047.pdf (Publisher’s version ) (Closed access) G protein coupled receptors (GPCRs) represent a major superfamily of transmembrane receptor proteins that are crucial in cellular signaling and are major pharmacological targets.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d1c567099847f80367b277913cc95a
https://pubmed.ncbi.nlm.nih.gov/17243823
https://pubmed.ncbi.nlm.nih.gov/17243823