Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Venkata R. Machha"'
Autor:
Pierce T. O'Neil, Alexandra J. Machen, Benjamin C. Deatherage, Caleb Trecazzi, Alexander Tischer, Venkata R. Machha, Matthew T. Auton, Michael R. Baldwin, Tommi A. White, Mark T. Fisher
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
The nucleotide-free chaperonin GroEL is capable of capturing transient unfolded or partially unfolded states that flicker in and out of existence due to large-scale protein dynamic vibrational modes. In this work, three short vignettes are presented
Externí odkaz:
https://doaj.org/article/a870c8a57acf4a8c80dd837c14933afb
Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer
Autor:
Rebecca A. Luchtel, Venkata R. Machha, Benjamin A. Gartrell, James Pullman, Jung In Yang, Alexander Tischer, Sassan Hafizi, Ahmed Aboumohamed, Joseph Albanese, Yiyu Zou, Xiaoyang Wang, Shanisha Gordon, Srinivas Aluri, Niraj Shenoy, Kith Pradhan, Nadia Ashai, Ritesh K. Aggarwal, Nandini Ramachandra
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This study demonstrates that underexpression of succinate dehydrogenase (SDH) subunits resulting in accumulation of oncogenic succinate is a common, adverse, epigenetic modulating feature in clear cell renal cell carcinoma (ccRCC), durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37bce31e1dc1c0dd43a7681404b8fba
https://doi.org/10.1073/pnas.2106947118
https://doi.org/10.1073/pnas.2106947118
Autor:
Dinesh Rakheja, Sanchari Bhattacharyya, Masako Suzuki, Benjamin A. Gartrell, Xiaosheng Wu, Emily Ressigue, Bradley C. Leibovich, Alexander Tischer, John C. Cheville, Lou Ann Gross, John M. Greally, Yiyu Zou, Thomas E. Witzig, Tushar D. Bhagat, Venkata R. Machha, R. Houston Thompson, Amit Verma, Christine M. Lohse, Shanisha Gordon-Mitchell, Stephen A. Boorjian, Gaurav Choudhary, Lance C. Pagliaro, Kith Pradhan, Li Fan Wong, Ulrich Steidl, Niraj Shenoy, Katalin Susztak, Beamon Agarwal
Publikováno v:
Journal of Clinical Investigation. 129:1612-1625
Although clear cell renal cell carcinoma (ccRCC) has been shown to result in widespread aberrant cytosine methylation and loss of 5-hydroxymethylcytosine (5hmC), the prognostic impact and therapeutic targeting of this epigenetic aberrancy has not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750099f155edb0673134c93f7a9f865e
https://doi.org/10.1172/jci98747
https://doi.org/10.1172/jci98747
Autor:
Srinivas Aluri, Ritesh K. Aggarwal, Jung In Yang, James Pullman, Alexander Tischer, Ahmed Aboumohamed, Yiyu Zou, Benjamin A. Gartrell, Venkata R. Machha, Shanisha Gordon, Sassan Hafizi, Xiaoyang Wang, Nandini Ramachandra, Kith Pradhan, Nadia Ashai, Joseph Albanese, Rebecca A. Luchtel, Niraj Shenoy
BackgroundReduced succinate dehydrogenase (SDH) activity resulting in adverse succinate accumulation was previously thought to be relevant only in 0.05-0.5% of kidney cancers associated with germline SDH mutations (categorized ‘SDH-deficient Renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d534498a3af47f8b2696c209ac0d05fb
https://doi.org/10.1101/2020.07.05.188433
https://doi.org/10.1101/2020.07.05.188433
Publikováno v:
Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 158-165 (2017)
Linker histones (H1) are the basic proteins in higher eukaryotes that are responsible for the final condensation of chromatin. In contrast to the nucleosome core histone proteins, the role of H1 in compacting DNA is not clearly understood. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f807a456cb27a2a99d11e69205af5e
http://www.sciencedirect.com/science/article/pii/S240558081730184X
http://www.sciencedirect.com/science/article/pii/S240558081730184X
Autor:
Frederick M. MacDonnell, J. Cole Gwin, Logan R. Martin, Jake C. White, Nagham Alatrash, Savannah J. West, Clinton G. Mikek, Carmen Shumaker, Edwin A. Lewis, Venkata R. Machha, Arseniy Butrin
Publikováno v:
European Journal of Inorganic Chemistry. 2017:3953-3960
ITC and CD were used to study the thermodynamics of RPC*G-quadruplex DNA (G4) complex formation. RPCs were [Ru(phen)₃]²+ (1²+), [Ru(phen)₂(dppz)]²+ (2²+), [Ru(phen)₂(tatpp)]²+ (3²+), and [Ru(phen)₂(tatpp)(phen)₂Ru]⁴+ (4⁴+) and tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff811de0b195f6be20618f9dc4d3b103
https://doi.org/10.1002/ejic.201700789
https://doi.org/10.1002/ejic.201700789
Autor:
Frederick M. MacDonnell, Jake C. White, Logan R. Martin, Nagham Alatrash, Edwin A. Lewis, Venkata R. Machha, Jesse I. DuPont, Clinton G. Mikek
Publikováno v:
European Journal of Inorganic Chemistry. 2017:3604-3611
ITC, CD, and ESI-MS techniques were used to study the thermodynamics of RPC*DNA complex formation for binding three different RPCs to duplex DNA. RPCs were [Ru(phen)₃]2+ (1), [Ru(phen)₂(dppz)]2+ (2), and [Ru(phen)₂(tatpp)]2+ (3). We examined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f8613ea42dafc1a7f0451b4e35353ac
https://doi.org/10.1002/ejic.201700462
https://doi.org/10.1002/ejic.201700462
Autor:
Maria A. Brehm, Rajiv K. Pruthi, Katelynn J. Nelton, Matthew Auton, Laurie L. Moon-Tasson, Rachel Leger, H. Robert Bergen, Venkata R. Machha, Alexander Tischer, Steven T. Whitten, Dong Chen, Tobias Obser, Reinhard Schneppenheim, Linda M. Benson, Marina Martinez-Vargas, Miguel A. Cruz
Publikováno v:
J Mol Biol
Von Willebrand factor (VWF), an exceptionally large multimeric plasma glycoprotein, functions to initiate coagulation by agglutinating platelets in the blood stream to sites of vascular injury. This primary hemostatic function is perturbed in type 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80575fb29bbe95b04573f054842a8d65
https://pubmed.ncbi.nlm.nih.gov/31628947
https://pubmed.ncbi.nlm.nih.gov/31628947
Publikováno v:
J Thromb Haemost
Background A molecular basis for von Willebrand factor (VWF) self-inhibition has been proposed by which the N-terminal and C-terminal flanking sequences of the globular A1 domain disulfide loop bind to and suppress the conformational dynamics of A1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7957a9968dd02a8ead7703bd6e42afe
https://pubmed.ncbi.nlm.nih.gov/31479573
https://pubmed.ncbi.nlm.nih.gov/31479573
Publikováno v:
Journal of thrombosis and haemostasis : JTHREFERENCES. 17(12)
Background Mutations in the β-switch of GPIbα cause gain-of-function in the platelet-type von Willebrand disease. Structures of free and A1-bound GPIbα suggest that the β-switch undergoes a conformational change from a coil to a β-hairpin. Objec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed759e12d56d97450a87b10889fe9fa
https://pubmed.ncbi.nlm.nih.gov/31448872
https://pubmed.ncbi.nlm.nih.gov/31448872