Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Venkata R M Chavali"'
Autor:
Rebecca J Salowe, Roy Lee, Selam Zenebe-Gete, Marquis Vaughn, Harini V Gudiseva, Maxwell Pistilli, Ava Kikut, Emily Becker, David W Collins, Jie He, Sayaka Merriam, Kristen Mulvihill, Nora Laberee, Sara Lomax-Reese, Windell Murphy, Jeffrey Henderer, Venkata R M Chavali, Qi N Cui, Ahmara G Ross, Victoria Addis, Prithvi S Sankar, Eydie Miller-Ellis, Maureen G Maguire, Joan M O'Brien
Publikováno v:
PLOS Global Public Health, Vol 2, Iss 8, p e0000416 (2022)
Genetic studies must enroll large numbers of participants to obtain adequate statistical power. Data are needed on how researchers can best use limited financial and practical resources to achieve these targets, especially in under-represented popula
Externí odkaz:
https://doaj.org/article/b802a01b6ce94bc0b0d9f5b720de9191
Autor:
Naira Khachatryan, Maxwell Pistilli, Maureen G Maguire, Rebecca J Salowe, Raymond M Fertig, Tanisha Moore, Harini V Gudiseva, Venkata R M Chavali, David W Collins, Ebenezer Daniel, Windell Murphy, Jeffrey D Henderer, Amanda Lehman, Qi Cui, Victoria Addis, Prithvi S Sankar, Eydie G Miller-Ellis, Joan M O'Brien
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0218804 (2019)
The purpose of this study was to investigate the association between gender and primary open-angle glaucoma (POAG) among African Americans and to assess demographic, systemic, and behavioral factors that may contribute to differences between genders.
Externí odkaz:
https://doaj.org/article/47a2722345c84fe897e34339b7b04100
Autor:
Catherine Cukras, Terry Gaasterland, Pauline Lee, Harini V Gudiseva, Venkata R M Chavali, Raghu Pullakhandam, Bruno Maranhao, Lee Edsall, Sandra Soares, G Bhanuprakash Reddy, Paul A Sieving, Radha Ayyagari
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50205 (2012)
Retinitis Pigmentosa (RP) is a common form of retinal degeneration characterized by photoreceptor degeneration and retinal pigment epithelium (RPE) atrophy causing loss of visual field and acuities. Exome sequencing identified a novel homozygous spli
Externí odkaz:
https://doaj.org/article/725666e23d8f49ff9fac916503b6c065
Autor:
Vidyullatha Vasireddy, Venkata R M Chavali, Victory T Joseph, Rajendra Kadam, Jonathan H Lin, Jeffrey A Jamison, Uday B Kompella, Geereddy Bhanuprakash Reddy, Radha Ayyagari
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21193 (2011)
The P23H mutation in the rhodopsin gene causes rhodopsin misfolding, altered trafficking and formation of insoluble aggregates leading to photoreceptor degeneration and autosomal dominant retinitis pigmentosa (RP). There are no effective therapies to
Externí odkaz:
https://doaj.org/article/4ba6948e92fe41898a70b7bee8cb27b5
Autor:
Ahmara G. Ross, Kimberly Dine, Devin S. McDougald, Thu T. Duong, Kenneth S. Shindler, Puya Aravand, Venkata R M Chavali, Jean Bennett, Reas S. Khan
Publikováno v:
Gene Therapy
SIRT1 prevents retinal ganglion cell (RGC) loss in models of optic neuropathy following pharmacologic activation or genetic overexpression. The exact mechanism of loss is not known, prior evidence suggests this is through oxidative stress to either n
Autor:
Kamaljot Gill, Teja Alapati, Devin S. McDougald, Vrathasha Vrathasha, Jason A. Mills, Sergei Nikonov, Thu T. Duong, Jie He, Naqi Haider, Sonika Rathi, Joan M O Apos Brien, Roman Nikonov, Venkata R M Chavali
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Glaucoma is a group of progressive optic neuropathies that share common biological and clinical characteristics including irreversible changes to the optic nerve and visual field loss caused by death of retinal ganglion cells (RGCs). The loss of RGCs
Autor:
Astra Dinculescu, Angel Soto-Hermida, Raul Ayala-Ramirez, Bhubanananda Sahu, Venkata R M Chavali, Shyamanga Borooah, Anil Kumar Chekuri, Akhila Alapati, Dirk-Uwe Bartsch, John Suk, Juan Carlos Zenteno, Radha Ayyagari, Monica M. Jablonski, Marina voronchikhina
Publikováno v:
Human Gene Therapy. 30:632-650
Patients harboring homozygous c.498_499insC mutations in MFRP demonstrate hyperopia, microphthalmia, retinitis pigmentosa, retinal pigment epithelial atrophy, variable degrees of foveal edema, and ...
Autor:
Qi N. Cui, Rebecca Salowe, Prithvi S. Sankar, Douglas C. Wallace, Maxwell Pistilli, Harini V. Gudiseva, Gui-Shuang Ying, Larry N. Singh, Naira Khachataryan, David W. Collins, Jie He, Venkata R M Chavali, Sayaka Merriam, Jeffrey D Henderer, Brian S. Cole, Eydie Miller-Ellis, Joan M. O'Brien, Victoria Addis
Publikováno v:
Experimental Eye Research. 181:85-89
Mitochondrial dysfunction has been implicated in the pathogenesis of primary open-angle glaucoma (POAG). However, the potential significance of mitochondrial DNA (mtDNA) haplogroups to POAG has not been evaluated in the overaffected African American
Autor:
Joan M. O'Brien, Ben T Trachtman, Sonika Rathi, Ian Danford, Harini V. Gudiseva, Maxwell Pistilli, David W. Collins, Gui-Shuang Ying, Lana Verkuil, Venkata R M Chavali, Naqi Haider, Jie He
Publikováno v:
British Journal of Ophthalmology. 103:1530-1536
AimsTo determine the association of single nucleotide polymorphisms (SNPs) downstream from the TMCO1 gene with primary open-angle glaucoma (POAG) in African Americans (AA).MethodsAA subjects were recruited for the Primary Open-Angle African American
Autor:
Louise F. Porter, Neil Saptarshi, Yongxiang Fang, Sonika Rathi, Anneke I. den Hollander, Eiko K. de Jong, Simon J. Clark, Paul N. Bishop, Timothy W. Olsen, Triantafillos Liloglou, Venkata R. M. Chavali, Luminita Paraoan
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-14 (2019)
Background Age-related macular degeneration (AMD) is a degenerative disorder of the central retina and the foremost cause of blindness. The retinal pigment epithelium (RPE) is a primary site of disease pathogenesis. The genetic basis of AMD is relati