KDM1A/LSD1 inhibition enhances chemotherapy response in ovarian cancer.

Autor: Chen Y; Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas, USA.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China., Johnson JD; Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas, USA., Jayamohan S; Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas, USA., He Y; Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas, USA.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China., Venkata PP; Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas, USA., Jamwal D; Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas, USA., Alejo S; Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas, USA., Zou Y; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, Texas, USA., Lai Z; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, Texas, USA.; Department of Molecular Medicine, UT Health San Antonio, San Antonio, Texas, USA., Viswanadhapalli S; Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas, USA.; Mays Cancer Center, UT Health San Antonio, San Antonio, Texas, USA., Vadlamudi RK; Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas, USA.; Mays Cancer Center, UT Health San Antonio, San Antonio, Texas, USA.; Audie L. Murphy South Texas Veterans Health Care System, San Antonio, Texas, USA., Kost E; Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas, USA., Sareddy GR; Department of Obstetrics and Gynecology, UT Health San Antonio, San Antonio, Texas, USA.; Mays Cancer Center, UT Health San Antonio, San Antonio, Texas, USA.

Publikováno v: Molecular carcinogenesis [Mol Carcinog] 2024 Oct; Vol. 63 (10), pp. 2026-2039. Date of Electronic Publication: 2024 Jul 11.

Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma.

Autor: Alejo S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Palacios BE; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Venkata PP; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., He Y; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Li W; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Johnson JD; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Chen Y; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Jayamohan S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Pratap UP; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Clarke K; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Zou Y; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Lv Y; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Weldon K; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Viswanadhapalli S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Lai Z; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Ye Z; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Chen Y; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Gilbert AR; Department of Pathology and Laboratory Medicine, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Suzuki T; The Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan., Tekmal RR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Zhao W; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Zheng S; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Vadlamudi RK; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Audie L. Murphy South Texas Veterans Health Care System, San Antonio, Texas, 78229, USA., Brenner AJ; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Hematology & Oncology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Sareddy GR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.

Publikováno v: Neuro-oncology [Neuro Oncol] 2023 Jul 06; Vol. 25 (7), pp. 1249-1261.

KDM1A inhibition augments the efficacy of rapamycin for the treatment of endometrial cancer.

Autor: Venkata PP; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Chen Y; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China., Alejo S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., He Y; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China., Palacios BE; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Loeffel I; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Liu J; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China., Pratap UP; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Gray G; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Achuthan Pillai SM; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Zou Y; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Lai Z; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX, 78229, USA; Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Suzuki T; The Institute of Scientific and Industrial Research, Osaka University, Japan., Viswanadhapalli S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Palakurthi S; Department of Pharmaceutical Sciences, Texas A&M University, Kingsville, TX, 78363, USA., Tekmal RR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Vadlamudi RK; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, 78229, USA; Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, TX 78229, USA., Kost E; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA., Sareddy GR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, 78229, USA. Electronic address: sareddy@uthscsa.edu.

Publikováno v: Cancer letters [Cancer Lett] 2022 Jan 01; Vol. 524, pp. 219-231. Date of Electronic Publication: 2021 Oct 18.

Activation of estrogen receptor beta signaling reduces stemness of glioma stem cells.

Autor: Sareddy GR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, USA., Pratap UP; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, USA., Venkata PP; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, USA., Zhou M; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, USA.; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha Shi, Hunan, People's Republic of China., Alejo S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, USA., Viswanadhapalli S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, USA., Tekmal RR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, USA., Brenner AJ; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, USA.; Hematology & Oncology, University of Texas Health San Antonio, San Antonio, Texas, USA., Vadlamudi RK; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, USA.

Publikováno v: Stem cells (Dayton, Ohio) [Stem Cells] 2021 May; Vol. 39 (5), pp. 536-550. Date of Electronic Publication: 2021 Feb 01.

PELP1 signaling contributes to medulloblastoma progression by regulating the NF-κB pathway.

Autor: Luo Y; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas.; Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Neurosurgery, The Second Xiangya Hospital, Xiangya School of Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China., Li M; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas.; Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China., Pratap UP; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas., Viswanadhapalli S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas., Liu J; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas.; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China., Venkata PP; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas., Altwegg KA; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas.; Mays Cancer Center, Cancer Development and Progression Program, University of Texas Health San Antonio, San Antonio, Texas., Palacios BE; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas., Li X; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas., Chen Y; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China., Rao MK; Mays Cancer Center, Cancer Development and Progression Program, University of Texas Health San Antonio, San Antonio, Texas.; Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, Texas., Brenner AJ; Mays Cancer Center, Cancer Development and Progression Program, University of Texas Health San Antonio, San Antonio, Texas.; Department of Hematology and Oncology, University of Texas Health San Antonio, San Antonio, Texas., Sareddy GR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas.; Mays Cancer Center, Cancer Development and Progression Program, University of Texas Health San Antonio, San Antonio, Texas., Vadlamudi RK; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas.; Mays Cancer Center, Cancer Development and Progression Program, University of Texas Health San Antonio, San Antonio, Texas.

Publikováno v: Molecular carcinogenesis [Mol Carcinog] 2020 Mar; Vol. 59 (3), pp. 281-292. Date of Electronic Publication: 2019 Dec 24.