Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Venkata Doppalapudi"'
Autor:
Judy Lucas, Guoyun Bai, Christopher J. O’Donnell, Sai Chetan K. Sukuru, Brian Rago, Sarah P. Hudson, Carolyn A. Leverett, Lioudmila Tchistiakova, Edmund I. Graziani, Anokha S. Ratnayake, Sylvia Musto, Jeffrey M. Casavant, Joseph Stock, Frank Loganzo, Christine Hosselet, Sujiet Puthenveetil, Andrew J. Bessire, Fengping Li, Xiaogang Han, Tracey Clark, Venkata Doppalapudi, Kimberly Ann Marquette, Beth C. Vetelino, Chakrapani Subramanyam, L. Nathan Tumey
Publikováno v:
ACS Medicinal Chemistry Letters. 7:977-982
As part of our efforts to develop new classes of tubulin inhibitor payloads for antibody-drug conjugate (ADC) programs, we developed a tubulysin ADC that demonstrated excellent in vitro activity but suffered from rapid metabolism of a critical acetat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13042dd359800510fc8a0a8b65af2bf4
https://doi.org/10.1021/acsmedchemlett.6b00195
https://doi.org/10.1021/acsmedchemlett.6b00195
Autor:
Christopher J. O’Donnell, Carolyn A. Leverett, Dingguo Liu, Beth C. Vetelino, Alison H. Varghese, Sai Chetan K. Sukuru, Sarah P. Hudson, Joseph Stock, Kevin D. Parris, Jayvardhan Pandit, Frank Loganzo, Guoyun Bai, Venkata Doppalapudi, Sylvia Musto, Bin Liu, Chakrapani Subramanyam
Publikováno v:
ACS medicinal chemistry letters. 7(11)
The tubulysin class of natural products has attracted much attention from the medicinal chemistry community due to its potent cytotoxicity against a wide range of human cancer cell lines, including significant activity in multidrug-resistant carcinom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6c2cec095e48b94da388eff99e96b4
https://pubmed.ncbi.nlm.nih.gov/27882198
https://pubmed.ncbi.nlm.nih.gov/27882198
Autor:
Steven Pirie-Shepherd, Jing-Yu Lai, Janet Do, Rodney W. Lappe, Gary Woodnutt, Nancy Levin, Hanhua Huang, Tom Leedom, John Rizzo, Venkata Doppalapudi, Curt W. Bradshaw, Lingna Li, Trina Osothprarop, Kim A. Johnson
Publikováno v:
Translational Oncology. 4(4):249-257
CVX-045 is produced by covalently attaching a thrombospondin 1 (TSP-1) mimetic comprising a peptidic sequence and a linker to the Fab binding site of a proprietary scaffold antibody. CVX-045 possesses the potency of the TSP-1-derived peptide, along w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1d256e4b5edfc3443b1f4e80fcca2f
Autor:
Joselyn Del Rosario, Michelle Parish, Bin Liu, Jie Huang, Ping Jin, Dingguo Liu, Marla J. Matin, Gary Woodnutt, Bryan Oates, Jing-Yu Lai, Nancy Levin, Rodney W. Lappe, Curt W. Bradshaw, Richard A. Lerner, Crystal Hagen, Abhijit Bhat, Robert E. Murphy, Zemeda W Ainekulu, Michael J. Shields, Venkata Doppalapudi, Lingna Li, Joel Desharnais
Publikováno v:
Proceedings of the National Academy of Sciences. 107:22611-22616
Bispecific antibodies (BsAbs) are regarded as promising therapeutic agents due to their ability to simultaneously bind two different antigens. Several bispecific modalities have been developed, but their utility is limited due to problems with stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3aab9d8b9d6a1442038b30b585337d7
https://doi.org/10.1073/pnas.1016478108
https://doi.org/10.1073/pnas.1016478108
Autor:
Teresa Aja, Giovanni Roxas, Nancy Tryder, Carlos F. Barbas, Curt Bradshaw, Mysore P. Ramprasad, Francesca Fang Liao, Lingna Li, David A. Griffith, Venkata Doppalapudi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:501-506
Aryl sulfonamide-based endothelin antagonists were synthesized and covalently linked to the reactive lysine of the m38C2 antibody to create a series of CovX-Bodies. These chemically programmed antibodies behaved as potent endothelin receptor antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004f3f7faa5d353622e71914c9200338
https://doi.org/10.1016/j.bmcl.2006.10.009
https://doi.org/10.1016/j.bmcl.2006.10.009
Autor:
Mark Horn, Ruth Muchekehu, Joselyn Del Rosario, Steven Pirie-Shepherd, Allan Kaspar, Dingguo Liu, Venkata Doppalapudi, Trina Osothprarop, Julia Coronella, Haim Moskowitz, Michael Bacica, Lioudmila Campbell, Anouk Dirksen
Publikováno v:
Translational oncology. 6(5)
Poor drug delivery and penetration of antibody-mediated therapies pose significant obstacles to effective treatment of solid tumors. This study explored the role of pharmacokinetics, valency, and molecular weight in maximizing drug delivery. Biodistr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34af362ceb89442cdb636bf9acb59cdc
https://pubmed.ncbi.nlm.nih.gov/24151537
https://pubmed.ncbi.nlm.nih.gov/24151537
Autor:
Alice Lee, Mark Vezina, Anthony S. Basile, Venkata Doppalapudi, Michael J. Shields, Theodore R. Johnson, Li-Ying Jiang, Genevieve Glazier
Publikováno v:
Investigative ophthalmologyvisual science. 52(9)
The pharmacokinetics of ophthalmic biotherapeutics are difficult to determine in human vitreous humor. Because of the high transparency of living tissue to near-infrared (NIR) light, the temporal changes in vitreous concentrations of a biomolecule la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0726b42254b9085be679989d3416bc1b
https://pubmed.ncbi.nlm.nih.gov/21791590
https://pubmed.ncbi.nlm.nih.gov/21791590
Autor:
Kristen E Bower, Ryan Preston, Emily Corner, Robert E. Murphy, Arvind G. Kinhikar, Xia Cao, Zemeda W Ainekulu, Aakash B Datt, Steven Pirie-Shepherd, Lioudmila Campbell, Gang Chen, Venkata Doppalapudi, Joselyn Del Rosario, Hanhua Huang, Bryan Oates, Rodney W. Lappe, Son Lam, Trina Osothprarop, Nancy Levin, Curt Bradshaw, Gary Woodnutt, Julie A Hoye, Judith Jimenez
Publikováno v:
Journal of medicinal chemistry. 54(5)
Novel phage-derived peptides are the first reported molecules specifically targeting human placental growth factor 1 (PlGF-1). Phage data enabled peptide modifications that decreased IC(50) values in PlGF-1/VEGFR-1 competition ELISA from 100 to 1 μM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d778774e40714032c80844e89f7bc95
https://pubmed.ncbi.nlm.nih.gov/21280651
https://pubmed.ncbi.nlm.nih.gov/21280651
Autor:
Gary Woodnutt, Nancy Levin, Steven Pirie-Shepherd, Curt W. Bradshaw, Lingna Li, Abhijit Bhat, Joselyn Del Rosario, Hanhua Huang, Dingguo Liu, Venkata Doppalapudi, Jing-Yu Lai, Janet Do, Rodney W. Lappe
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 17(5)
Purpose: Angiopoietin-1 (Ang1) plays a key role in maintaining stable vasculature, whereas in a tumor Ang2 antagonizes Ang1's function and promotes the initiation of the angiogenic switch. Specifically targeting Ang2 is a promising anticancer strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8538c39ed08200a64c23d9d1d109cb16
https://pubmed.ncbi.nlm.nih.gov/21233403
https://pubmed.ncbi.nlm.nih.gov/21233403
Autor:
Venkata Doppalapudi, Sukumar Sakamuri, Joselyn Del Rosario, Dorian Willhite, Julia Coronella, Kim A. Johnson, Yanwen Fu, Nancy Levin, John Rizzo, Abhijit Bhat
Publikováno v:
Cancer Research. 72:2849-2849
Here we describe a series of CXCR4 antagonist CovX-Bodies, produced by covalently attaching CXCR4 antagonist peptides to a humanized IgG1 molecule with the goal of producing molecules with the potency and specificity of peptides and the pharmacokinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8b371a01d7b728fcb062c8c2675e09a
https://doi.org/10.1158/1538-7445.am2012-2849
https://doi.org/10.1158/1538-7445.am2012-2849