Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Venkat Pisupati"'
Autor:
Miranda Robbins, Venkat Pisupati, Roberta Azzarelli, Samer I. Nehme, Roger A. Barker, Ljiljana Fruk, Gabriele S. Kaminski Schierle
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2021)
Abstract Background Stem cell-based therapies for neurodegenerative diseases like Parkinson’s disease are a promising approach in regenerative medicine and are now moving towards early stage clinical trials. However, a number of challenges remain i
Externí odkaz:
https://doaj.org/article/64d85d1a1edc4887b5086fb9bb822a05
Autor:
Caroline B. Pantazis, Andrian Yang, Erika Lara, Justin A. McDonough, Cornelis Blauwendraat, Lirong Peng, Hideyuki Oguro, Jitendra Kanaujiya, Jizhong Zou, David Sebesta, Gretchen Pratt, Erin Cross, Jeffrey Blockwick, Philip Buxton, Lauren Kinner-Bibeau, Constance Medura, Christopher Tompkins, Stephen Hughes, Marianita Santiana, Faraz Faghri, Mike A. Nalls, Daniel Vitale, Shannon Ballard, Yue A. Qi, Daniel M. Ramos, Kailyn M. Anderson, Julia Stadler, Priyanka Narayan, Jason Papademetriou, Luke Reilly, Matthew P. Nelson, Sanya Aggarwal, Leah U. Rosen, Peter Kirwan, Venkat Pisupati, Steven L. Coon, Sonja W. Scholz, Theresa Priebe, Miriam Öttl, Jian Dong, Marieke Meijer, Lara J.M. Janssen, Vanessa S. Lourenco, Rik van der Kant, Dennis Crusius, Dominik Paquet, Ana-Caroline Raulin, Guojun Bu, Aaron Held, Brian J. Wainger, Rebecca M.C. Gabriele, Jackie M. Casey, Selina Wray, Dad Abu-Bonsrah, Clare L. Parish, Melinda S. Beccari, Don W. Cleveland, Emmy Li, Indigo V.L. Rose, Martin Kampmann, Carles Calatayud Aristoy, Patrik Verstreken, Laurin Heinrich, Max Y. Chen, Birgitt Schüle, Dan Dou, Erika L.F. Holzbaur, Maria Clara Zanellati, Richa Basundra, Mohanish Deshmukh, Sarah Cohen, Richa Khanna, Malavika Raman, Zachary S. Nevin, Madeline Matia, Jonas Van Lent, Vincent Timmerman, Bruce R. Conklin, Katherine Johnson Chase, Ke Zhang, Salome Funes, Daryl A. Bosco, Lena Erlebach, Marc Welzer, Deborah Kronenberg-Versteeg, Guochang Lyu, Ernest Arenas, Elena Coccia, Lily Sarrafha, Tim Ahfeldt, John C. Marioni, William C. Skarnes, Mark R. Cookson, Michael E. Ward, Florian T. Merkle
Publikováno v:
Cell stem cell 29(12), 1685-1702.e22 (2022). doi:10.1016/j.stem.2022.11.004
Cell stem cell
Cell Stem Cell, 29(12), 1685-1702.e22. Cell Press
Pantazis, C B, Yang, A, Lara, E, McDonough, J A, Blauwendraat, C, Peng, L, Oguro, H, Kanaujiya, J, Zou, J, Sebesta, D, Pratt, G, Cross, E, Blockwick, J, Buxton, P, Kinner-Bibeau, L, Medura, C, Tompkins, C, Hughes, S, Santiana, M, Faghri, F, Nalls, M A, Vitale, D, Ballard, S, Qi, Y A, Ramos, D M, Anderson, K M, Stadler, J, Narayan, P, Papademetriou, J, Reilly, L, Nelson, M P, Aggarwal, S, Rosen, L U, Kirwan, P, Pisupati, V, Coon, S L, Scholz, S W, Priebe, T, Öttl, M, Dong, J, Meijer, M, Janssen, L J M, Lourenco, V S, van der Kant, R, Crusius, D, Paquet, D, Raulin, A C, Bu, G, Held, A, Wainger, B J, Gabriele, R M C, Casey, J M, Wray, S, Abu-Bonsrah, D, Parish, C L, Beccari, M S, Cleveland, D W, Li, E, Rose, I V L, Kampmann, M, Calatayud Aristoy, C, Verstreken, P, Heinrich, L, Chen, M Y, Schüle, B, Dou, D, Holzbaur, E L F, Zanellati, M C, Basundra, R, Deshmukh, M, Cohen, S, Khanna, R, Raman, M, Nevin, Z S, Matia, M, Van Lent, J, Timmerman, V, Conklin, B R, Johnson Chase, K, Zhang, K, Funes, S, Bosco, D A, Erlebach, L, Welzer, M, Kronenberg-Versteeg, D, Lyu, G, Arenas, E, Coccia, E, Sarrafha, L, Ahfeldt, T, Marioni, J C, Skarnes, W C, Cookson, M R, Ward, M E & Merkle, F T 2022, ' A reference human induced pluripotent stem cell line for large-scale collaborative studies ', Cell Stem Cell, vol. 29, no. 12, pp. 1685-1702.e22 . https://doi.org/10.1016/j.stem.2022.11.004
Pantazis, C B, Yang, A, Lara, E, McDonough, J A, Blauwendraat, C, Peng, L, Oguro, H, Kanaujiya, J, Zou, J, Sebesta, D, Pratt, G, Cross, E, Blockwick, J, Buxton, P, Kinner-Bibeau, L, Medura, C, Tompkins, C, Hughes, S, Santiana, M, Faghri, F, Nalls, M A, Vitale, D, Ballard, S, Qi, Y A, Ramos, D M, Anderson, K M, Stadler, J, Narayan, P, Papademetriou, J, Reilly, L, Nelson, M P, Aggarwal, S, Rosen, L U, Kirwan, P, Pisupati, V, Coon, S L, Scholz, S W, Priebe, T, Öttl, M, Dong, J, Meijer, M, Janssen, L J M, Lourenco, V S, van der Kant, R, Crusius, D, Paquet, D, Raulin, A-C, Bu, G, Held, A, Wainger, B J, Gabriele, R M C, Casey, J M, Wray, S, Abu-Bonsrah, D, Parish, C L, Beccari, M S, Cleveland, D W, Li, E, Rose, I V L, Kampmann, M, Calatayud Aristoy, C, Verstreken, P, Heinrich, L, Chen, M Y, Schüle, B, Dou, D, Holzbaur, E L F, Zanellati, M C, Basundra, R, Deshmukh, M, Cohen, S, Khanna, R, Raman, M, Nevin, Z S, Matia, M, van Lent, J, Timmerman, V, Conklin, B R, Johnson Chase, K, Zhang, K, Funes, S, Bosco, D A, Erlebach, L, Welzer, M, Kronenberg-Versteeg, D, Lyu, G, Arenas, E, Coccia, E, Sarrafha, L, Ahfeldt, T, Marioni, J C, Skarnes, W C, Cookson, M R, Ward, M E & Merkle, F T 2022, ' A reference human induced pluripotent stem cell line for large-scale collaborative studies ', Cell Stem Cell, vol. 29, no. 12, pp. 1685-1702.e22 . https://doi.org/10.1016/j.stem.2022.11.004
Cell Stem Cell, 29(12), 1685-1702.e22. Elsevier
Cell stem cell
Cell Stem Cell, 29(12), 1685-1702.e22. Cell Press
Pantazis, C B, Yang, A, Lara, E, McDonough, J A, Blauwendraat, C, Peng, L, Oguro, H, Kanaujiya, J, Zou, J, Sebesta, D, Pratt, G, Cross, E, Blockwick, J, Buxton, P, Kinner-Bibeau, L, Medura, C, Tompkins, C, Hughes, S, Santiana, M, Faghri, F, Nalls, M A, Vitale, D, Ballard, S, Qi, Y A, Ramos, D M, Anderson, K M, Stadler, J, Narayan, P, Papademetriou, J, Reilly, L, Nelson, M P, Aggarwal, S, Rosen, L U, Kirwan, P, Pisupati, V, Coon, S L, Scholz, S W, Priebe, T, Öttl, M, Dong, J, Meijer, M, Janssen, L J M, Lourenco, V S, van der Kant, R, Crusius, D, Paquet, D, Raulin, A C, Bu, G, Held, A, Wainger, B J, Gabriele, R M C, Casey, J M, Wray, S, Abu-Bonsrah, D, Parish, C L, Beccari, M S, Cleveland, D W, Li, E, Rose, I V L, Kampmann, M, Calatayud Aristoy, C, Verstreken, P, Heinrich, L, Chen, M Y, Schüle, B, Dou, D, Holzbaur, E L F, Zanellati, M C, Basundra, R, Deshmukh, M, Cohen, S, Khanna, R, Raman, M, Nevin, Z S, Matia, M, Van Lent, J, Timmerman, V, Conklin, B R, Johnson Chase, K, Zhang, K, Funes, S, Bosco, D A, Erlebach, L, Welzer, M, Kronenberg-Versteeg, D, Lyu, G, Arenas, E, Coccia, E, Sarrafha, L, Ahfeldt, T, Marioni, J C, Skarnes, W C, Cookson, M R, Ward, M E & Merkle, F T 2022, ' A reference human induced pluripotent stem cell line for large-scale collaborative studies ', Cell Stem Cell, vol. 29, no. 12, pp. 1685-1702.e22 . https://doi.org/10.1016/j.stem.2022.11.004
Pantazis, C B, Yang, A, Lara, E, McDonough, J A, Blauwendraat, C, Peng, L, Oguro, H, Kanaujiya, J, Zou, J, Sebesta, D, Pratt, G, Cross, E, Blockwick, J, Buxton, P, Kinner-Bibeau, L, Medura, C, Tompkins, C, Hughes, S, Santiana, M, Faghri, F, Nalls, M A, Vitale, D, Ballard, S, Qi, Y A, Ramos, D M, Anderson, K M, Stadler, J, Narayan, P, Papademetriou, J, Reilly, L, Nelson, M P, Aggarwal, S, Rosen, L U, Kirwan, P, Pisupati, V, Coon, S L, Scholz, S W, Priebe, T, Öttl, M, Dong, J, Meijer, M, Janssen, L J M, Lourenco, V S, van der Kant, R, Crusius, D, Paquet, D, Raulin, A-C, Bu, G, Held, A, Wainger, B J, Gabriele, R M C, Casey, J M, Wray, S, Abu-Bonsrah, D, Parish, C L, Beccari, M S, Cleveland, D W, Li, E, Rose, I V L, Kampmann, M, Calatayud Aristoy, C, Verstreken, P, Heinrich, L, Chen, M Y, Schüle, B, Dou, D, Holzbaur, E L F, Zanellati, M C, Basundra, R, Deshmukh, M, Cohen, S, Khanna, R, Raman, M, Nevin, Z S, Matia, M, van Lent, J, Timmerman, V, Conklin, B R, Johnson Chase, K, Zhang, K, Funes, S, Bosco, D A, Erlebach, L, Welzer, M, Kronenberg-Versteeg, D, Lyu, G, Arenas, E, Coccia, E, Sarrafha, L, Ahfeldt, T, Marioni, J C, Skarnes, W C, Cookson, M R, Ward, M E & Merkle, F T 2022, ' A reference human induced pluripotent stem cell line for large-scale collaborative studies ', Cell Stem Cell, vol. 29, no. 12, pp. 1685-1702.e22 . https://doi.org/10.1016/j.stem.2022.11.004
Cell Stem Cell, 29(12), 1685-1702.e22. Elsevier
Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying development and disease, but the considerable phenotypic variation between lines makes it challenging to replicate key findings and integrate data across research group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13421d333d6a58e4ae5a7a5137ffe431
https://hdl.handle.net/1871.1/7a28e7d3-76b6-44b1-99f6-5924a18844de
https://hdl.handle.net/1871.1/7a28e7d3-76b6-44b1-99f6-5924a18844de
Autor:
Gabriele S. Kaminski Schierle, Roger A. Barker, Venkat Pisupati, Miranda Robbins, Samer I. Nehme, Roberta Azzarelli, Ljiljana Fruk
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Stem cell-based therapies for neurodegenerative diseases like Parkinson’s disease are a promising approach in regenerative medicine and are now moving towards early stage clinical trials. However, a number of challenges remain including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f2bfbba924d739230d6f6588f44f33
https://pubmed.ncbi.nlm.nih.gov/34774094
https://pubmed.ncbi.nlm.nih.gov/34774094
Autor:
Caroline B. Pantazis, Andrian Yang, Erika Lara, Justin A. McDonough, Cornelis Blauwendraat, Lirong Peng, Hideyuki Oguro, Jitendra Kanaujiya, Jizhong Zou, David Sebesta, Gretchen Pratt, Erin Cross, Jeffrey Blockwick, Philip Buxton, Lauren Kinner-Bibeau, Constance Medura, Christopher Tompkins, Stephen Hughes, Marianita Santiana, Faraz Faghri, Mike A. Nalls, Daniel Vitale, Shannon Ballard, Yue A. Qi, Daniel M. Ramos, Kailyn M. Anderson, Julia Stadler, Priyanka Narayan, Jason Papademetriou, Luke Reilly, Matthew P. Nelson, Sanya Aggarwal, Leah U. Rosen, Peter Kirwan, Venkat Pisupati, Steven L. Coon, Sonja W. Scholz, Theresa Priebe, Miriam Öttl, Jian Dong, Marieke Meijer, Lara J.M. Janssen, Vanessa S. Lourenco, Rik van der Kant, Dennis Crusius, Dominik Paquet, Ana-Caroline Raulin, Guojun Bu, Aaron Held, Brian J. Wainger, Rebecca M.C. Gabriele, Jackie M Casey, Selina Wray, Dad Abu-Bonsrah, Clare L. Parish, Melinda S. Beccari, Don W. Cleveland, Emmy Li, Indigo V.L. Rose, Martin Kampmann, Carles Calatayud Aristoy, Patrik Verstreken, Laurin Heinrich, Max Y. Chen, Birgitt Schüle, Dan Dou, Erika L.F. Holzbaur, Maria Clara Zanellati, Richa Basundra, Mohanish Deshmukh, Sarah Cohen, Richa Khanna, Malavika Raman, Zachary S. Nevin, Madeline Matia, Jonas Van Lent, Vincent Timmerman, Bruce R. Conklin, Katherine Johnson Chase, Ke Zhang, Salome Funes, Daryl A. Bosco, Lena Erlebach, Marc Welzer, Deborah Kronenberg-Versteeg, Guochang Lyu, Ernest Arenas, Elena Coccia, Lily Sarrafha, Tim Ahfeldt, John C. Marioni, William C. Skarnes, Mark R. Cookson, Michael E. Ward, Florian T. Merkle
Publikováno v:
bioRxiv
Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying development and disease, but the considerable phenotypic variation between lines makes it challenging to replicate key findings and integrate data across research group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16be7beeb9661c1c36cbc5f9bea57195
Autor:
Stuart J. Forbes, Molly M. Stevens, P. Stephen Patrick, Daniel J. Stuckey, Venkat Pisupati, Roger A. Barker, Wei-Li Kuan, James P. K. Armstrong, Richard O.C. Oreffo, Anne C. Roques, Fiona M. Watt, Timothy J. Keane, Claire M. Mooney
Publikováno v:
Sci Transl Med
Armstrong, J P K, Keane, T, Roques, A C, Patrick, P S, Mooney, C M, Kuan, W-L, Pisupati, V, Oreffo, R O C, Stuckey, D, Watt, F M, Forbes, S, Barker, R A & Stevens, M M 2020, ' A blueprint for translational regenerative medicine ', Science Translational Medicine, vol. 12, no. 572, eaaz2253 . https://doi.org/10.1126/scitranslmed.aaz2253
Armstrong, J P K, Keane, T, Roques, A C, Patrick, P S, Mooney, C M, Kuan, W-L, Pisupati, V, Oreffo, R O C, Stuckey, D, Watt, F M, Forbes, S, Barker, R A & Stevens, M M 2020, ' A blueprint for translational regenerative medicine ', Science Translational Medicine, vol. 12, no. 572, eaaz2253 . https://doi.org/10.1126/scitranslmed.aaz2253
The last few decades have produced a large number of proof-of-concept studies in regenerative medicine. However, the route to clinical adoption is fraught with technical and translational obstacles that frequently consign promising academic solutions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4484dfed5d5df52e8227848697bf68f3
https://europepmc.org/articles/PMC7610850/
https://europepmc.org/articles/PMC7610850/
Autor:
David E. Neal, Anne Y. Warren, Antonio Ramos-Montoya, Satoshi Hori, Vincent J. Gnanapragasam, Karan Wadhwa, Venkat Pisupati, Vincent Zecchini
Publikováno v:
International Journal of Cancer
We have previously reported that the negative signaling regulator Similar Expression to FGF (hSef) is downregulated in prostate cancer and its loss is associated with clinical metastasis. Here, we explored the mechanistic basis of this finding. We fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b55c346eed291a19819ea46bc244e6
http://europepmc.org/articles/PMC5324539
http://europepmc.org/articles/PMC5324539
Autor:
Amit Chandra, Venkat Pisupati, Lynn Csontos, Jason A. Halliwell, Glyn Stacey, Mark J.S. McCall, Zoe Hewitt, Malin Parmar, Giulio Cossu, M Beatrice Panico, Ravenska Wagey, Harry Moore, Oliver Thompson, Peter W. Andrews, Valentin P. Shichkin, Thomas J. R. Frith, Ivana Barbaric, Francesco Tedesco, Alison Stacey, Charlotta Böiers
Publikováno v:
Stacey, G N, Andrews, P W, Barbaric, I, Boiers, C, Chandra, A, Cossu, G, Csontos, L, Frith, T J, Halliwell, J A, Hewitt, Z, McCall, M, Moore, H D, Parmar, M, Panico, M B, Pisupati, V, Shichkin, V P, Stacey, A R, Tedesco, F S, Thompson, O & Wagey, R 2019, ' Stem cell culture conditions and stability : A joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform ', Regenerative Medicine, vol. 14, no. 3, pp. 243-255 . https://doi.org/10.2217/rme-2019-0001
Regenerative medicine
Regenerative Medicine
Regenerative medicine
Regenerative Medicine
Human stem cells have the potential to transform medicine. However, hurdles remain to ensure that manufacturing processes produce safe and effective products. A thorough understanding of the biological processes occurring during manufacture is fundam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18eff64c36c3388d3bb4bde8756340e0
https://www.research.manchester.ac.uk/portal/en/publications/stem-cell-culture-conditions-and-stability(952cea45-8afc-4e69-a2ba-ee8a49560aa5).html
https://www.research.manchester.ac.uk/portal/en/publications/stem-cell-culture-conditions-and-stability(952cea45-8afc-4e69-a2ba-ee8a49560aa5).html
Autor:
Yang Liu, Hiroyoshi Hattori, Asta Bjork Jonsdottir, Anand D. Jeyasekharan, Miyoung Lee, Nabieh Ayoub, Eeson Rajendra, Yaara Ofir-Rosenfeld, Simon Schlachter, Jane M. Savill, Ashok R. Venkitaraman, Elayanambi Sundaramoorthy, Venkat Pisupati, Clemens F. Kaminski, Ko Sato
Publikováno v:
Nature structural & molecular biology
Germline missense mutations affecting a single BRCA2 allele predispose humans to cancer. Here we identify a protein-targeting mechanism that is disrupted by the cancer-associated mutation, BRCA2(D2723H), and that controls the nuclear localization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e321af8a42281035f12e287a37eb45
https://doi.org/10.1038/nsmb.2666
https://doi.org/10.1038/nsmb.2666
Autor:
Philippe I. H. Bastiaens, Christian Hedberg, Michael Hanzal-Bayer, Alfred Wittinghofer, Shehab Ismail, David Perera, Ashok R. Venkitaraman, Ferdinandos Skoulidis, Hernãin E. Grecco, Liam D. Cassidy, Venkat Pisupati, Anchal Chandra
Publikováno v:
Nature Cell Biology. 14:148-158
We identify a role for the GDI-like solubilizing factor (GSF) PDEδ in modulating signalling through Ras family G proteins by sustaining their dynamic distribution in cellular membranes. We show that the GDI-like pocket of PDEδ binds and solubilizes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9601f88c82e5aa9a566dddd9958ab049
https://doi.org/10.1038/ncb2394
https://doi.org/10.1038/ncb2394
Autor:
Ashok R. Venkitaraman, Kenneth P. Olive, Jon G. Jonasson, Michael Lim, Florian A. Karreth, Venkat Pisupati, Liam D. Cassidy, Ferdinandos Skoulidis, Jorunn E. Eyfjord, Hordur Bjarnason, Susan A. Clatworthy, Susan E. Davies, David A. Tuveson, Lorraine Barber
Publikováno v:
Cancer Cell. 18(5):499-509
Summary Inherited heterozygous BRCA2 mutations predispose carriers to tissue-specific cancers, but somatic deletion of the wild-type allele is considered essential for carcinogenesis. We find in a murine model of familial pancreatic cancer that germl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5ca09c04615931e734b189f99727c7