Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Venkat Jasti"'
Autor:
Ramakrishna Nirogi, John Ieni, Vinod Kumar Goyal, Jyothsna Ravula, Satish Jetta, Anil Shinde, Pradeep Jayarajan, Vijay Benade, Veera Raghava Chowdary Palacharla, Dhanunjay Kumar Dogiparti, Venkat Jasti, Alireza Atri, Jeffrey Cummings
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction This study explored the efficacy and safety of a serotonin‐6 receptor antagonist, masupirdine, as adjunct treatment in patients with moderate Alzheimer's disease (AD) concomitantly treated with donepezil and memantine. Methods
Externí odkaz:
https://doaj.org/article/2946c8a2c70042bc98555d45982352fa
Autor:
Ramakrishna Nirogi, Pradeep Jayarajan, Anil Shinde, Abdul Rasheed Mohammed, Venkata Ramalingayya Grandhi, Vijay Benade, Vinod Kumar Goyal, Renny Abraham, Venkat Jasti, Jeffrey Cummings
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 309 (2023)
Serotonin (5-HT) plays an important role in the regulation of several basic functions of the central and peripheral nervous system. Among the 5-HT receptors, serotonin-6 (5-HT6) receptor has been an area of substantial research. 5-HT6 receptor is a G
Externí odkaz:
https://doaj.org/article/ffb38ef38eaf41d680d033f6aa4d190b
Autor:
Ramakrishna Nirogi, Pradeep Jayarajan, Vijay Benade, Anil Shinde, Vinod Kumar Goyal, Satish Jetta, Jyothsna Ravula, Renny Abraham, Venkata Ramalingayya Grandhi, Ramkumar Subramanian, Santosh Kumar Pandey, Rajesh Kumar Badange, Abdul Rasheed Mohammed, Venkat Jasti, Clive Ballard, Jeffrey Cummings
Publikováno v:
International Journal of Geriatric Psychiatry. 37
The effects of masupirdine on the neuropsychiatric symptoms were explored.Masupirdine (SUVN-502) was evaluated for its effects on cognition in patients with moderate AD. The prespecified primary outcome showed no drug-placebo difference. Post hoc ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c1875b71599152ba90ab4d2f2a5e2b
https://doi.org/10.1002/gps.5813
https://doi.org/10.1002/gps.5813
Autor:
Ramakrishna Nirogi, Vinod Kumar Goyal, Vijay Benade, Ramkumar Subramanian, Jyothsna Ravula, Satish Jetta, Anil Shinde, Santosh Kumar Pandey, Pradeep Jayarajan, Venkat Jasti, Jeffrey Cummings
Publikováno v:
Neurology and therapy. 11(4)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive deterioration in cognition, memory and activities of daily living. Selective blockade of serotonin-6 (5-HTThe efficacy and safety of masupirdine were evaluated in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0516acbb5991d8def5c116e945f0b33
https://pubmed.ncbi.nlm.nih.gov/35908254
https://pubmed.ncbi.nlm.nih.gov/35908254
Autor:
Ramkumar Subramanian, Vijay Benade, Arunkumar Manoharan, Narender Ganuga, Ramakrishna Nirogi, Rajesh Kumar Badange, Surendra Petlu, Venkat Jasti, Rajesh Babu Medapati, Gopinadh Bhyrapuneni, Shinde Anil Karbhari, Venkata Ramalingayya Grandhi, Renny Abraham, Pradeep Jayarajan, Sudhakar Gandipudi
Publikováno v:
Journal of Psychopharmacology. 35:713-729
Background: Central histamine H3 receptors are a family of presynaptic auto and heteroreceptors. Blockade of the presynaptic H3 receptors activates the downstream pathway(s) involved in the processes of learning and memory, making it a potential ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1920b53ccf7febfacf8c7c3e31f92d
https://doi.org/10.1177/0269881120986418
https://doi.org/10.1177/0269881120986418
Autor:
Jagadeesh Babu Thentu, Nageswararao Muddana, Renny Abraham, Raghava Choudary Palacharla, Srinivasa Rao Ravella, Ramkumar Subramanian, Venkat Reddy Mekala, Shinde Anil Karbhari, Narsimha Bogaraju, Abdul Rasheed Mohammed, Gopinadh Bhyrapuneni, Ramakrishna Nirogi, Venkat Jasti
Publikováno v:
Journal of Medicinal Chemistry. 63:2833-2853
A series of chemical optimizations guided by in vitro affinity at the α4β2 receptor in combination with selectivity against the α3β4 receptor, pharmacokinetic evaluation, and in vivo efficacy in a forced swim test resulted in identification of 3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ac0220a5003d1184e2ad4655e6b000
https://doi.org/10.1021/acs.jmedchem.9b00790
https://doi.org/10.1021/acs.jmedchem.9b00790
Autor:
Ramakrishna Nirogi, Vijay Benade, Ramkumar Ramkumar, Subramanian Subramanian, Satish Jetta, Anil Shinde, Vinod Goyal, Santosh Pandey, Pradeep Jayarajan, Venkat Jasti
Publikováno v:
Medical Research Archives. 10
Alzheimer's disease (AD) is an age-related progressive neurodegenerative brain disorder with cognitive symptoms as a hallmark phenotype of the disease. Masupirdine, a pure serotonin 6 (5-HT6) receptor antagonist is being developed for the treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e88885b6b2cdc1a3266c20d54e4e18b
https://doi.org/10.18103/mra.v10i9.3061
https://doi.org/10.18103/mra.v10i9.3061
Autor:
Ramakrishna, Nirogi, Abdul Rasheed, Mohammed, Anil Karbhari, Shinde, Shankar Reddy, Gagginapally, Durga Malleshwari, Kancharla, Srinivasa Rao, Ravella, Narsimha, Bogaraju, Vanaja Reddy, Middekadi, Ramkumar, Subramanian, Raghava Choudary, Palacharla, Vijay, Benade, Nageswararao, Muddana, Renny, Abraham, Rajesh Babu, Medapati, Jagadeesh Babu, Thentu, Venkat Reddy, Mekala, Surendra, Petlu, Bujji Babu, Lingavarapu, Sivasekhar, Yarra, Narendra, Kagita, Vinod Kumar, Goyal, Santosh Kumar, Pandey, Venkat, Jasti
Publikováno v:
Journal of medicinal chemistry. 64(15)
A series of oxadiazole derivatives were synthesized and evaluated as 5-hydroxytryptamine-4 receptor (5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0658b7f6a1d5f4d39f7637a5b2805752
https://pubmed.ncbi.nlm.nih.gov/34251799
https://pubmed.ncbi.nlm.nih.gov/34251799
Autor:
Ramasastry Kambhampati, Ramkumar Subramanian, Renny Abraham, Nageswararao Muddana, Venkat Jasti, Venkat Reddy Mekala, Rajesh Babu Medapati, Ramakrishna Nirogi, Vijay Benade, Gopinadh Bhyrapuneni, Anil Shinde, Pradeep Jayarajan
Publikováno v:
Behavioural Pharmacology. 30:16-35
Research in Alzheimer's disease is going through a big turnaround. New palliative therapies are being reconsidered for the effective management of disease because of setbacks in the development of disease-modifying therapies. Serotonin 6 (5-HT6) rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8901f07622776d0009654723d67114
https://doi.org/10.1097/fbp.0000000000000414
https://doi.org/10.1097/fbp.0000000000000414
Autor:
Kiran Kumar Kandukuri, Anil Shinde, Santoshkumar Pandey, Thrinath Reddy Bandyala, Abdul Rasheed Mohammed, Raghava Choudary Palacharla, Ramkumar Subramanian, Kumar Bojja, Sravanthi Manchineella, Pramod Kumar Achanta, Sangram Keshari Saraf, Venkat Jasti, Ramakrishna Nirogi, Rajesh Kumar Badange, Pradeep Jayarajan, Vijay Benade, Veena Reballi
Publikováno v:
Journal of Medicinal Chemistry. 62:1203-1217
A series of chemical optimizations guided by in vitro affinity at a histamine H3 receptor (H3R), physicochemical properties, and pharmacokinetics in rats resulted in identification of N-[4-(1-cyclobutyl-piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a6a6e9590419cd78629224ee0312c10
https://doi.org/10.1021/acs.jmedchem.8b01280
https://doi.org/10.1021/acs.jmedchem.8b01280