Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions

Autor: Binsheng Gong, Dan Li, Rebecca Kusko, Natalia Novoradovskaya, Yifan Zhang, Shangzi Wang, Carlos Pabón-Peña, Zhihong Zhang, Kevin Lai, Wanshi Cai, Jennifer S. LoCoco, Eric Lader, Todd A. Richmond, Vinay K. Mittal, Liang-Chun Liu, Donald J. Johann, James C. Willey, Pierre R. Bushel, Ying Yu, Chang Xu, Guangchun Chen, Daniel Burgess, Simon Cawley, Kristina Giorda, Nathan Haseley, Fujun Qiu, Katherine Wilkins, Hanane Arib, Claire Attwooll, Kevin Babson, Longlong Bao, Wenjun Bao, Anne Bergstrom Lucas, Hunter Best, Ambica Bhandari, Halil Bisgin, James Blackburn, Thomas M. Blomquist, Lisa Boardman, Blake Burgher, Daniel J. Butler, Chia-Jung Chang, Alka Chaubey, Tao Chen, Marco Chierici, Christopher R. Chin, Devin Close, Jeffrey Conroy, Jessica Cooley Coleman, Daniel J. Craig, Erin Crawford, Angela del Pozo, Ira W. Deveson, Daniel Duncan, Agda Karina Eterovic, Xiaohui Fan, Jonathan Foox, Cesare Furlanello, Abhisek Ghosal, Sean Glenn, Meijian Guan, Christine Haag, Xinyi Hang, Scott Happe, Brittany Hennigan, Jennifer Hipp, Huixiao Hong, Kyle Horvath, Jianhong Hu, Li-Yuan Hung, Mirna Jarosz, Jennifer Kerkhof, Benjamin Kipp, David Philip Kreil, Paweł Łabaj, Pablo Lapunzina, Peng Li, Quan-Zhen Li, Weihua Li, Zhiguang Li, Yu Liang, Shaoqing Liu, Zhichao Liu, Charles Ma, Narasimha Marella, Rubén Martín-Arenas, Dalila B. Megherbi, Qingchang Meng, Piotr A. Mieczkowski, Tom Morrison, Donna Muzny, Baitang Ning, Barbara L. Parsons, Cloud P. Paweletz, Mehdi Pirooznia, Wubin Qu, Amelia Raymond, Paul Rindler, Rebecca Ringler, Bekim Sadikovic, Andreas Scherer, Egbert Schulze, Robert Sebra, Rita Shaknovich, Qiang Shi, Tieliu Shi, Juan Carlos Silla-Castro, Melissa Smith, Mario Solís López, Ping Song, Daniel Stetson, Maya Strahl, Alan Stuart, Julianna Supplee, Philippe Szankasi, Haowen Tan, Lin-ya Tang, Yonghui Tao, Shraddha Thakkar, Danielle Thierry-Mieg, Jean Thierry-Mieg, Venkat J. Thodima, David Thomas, Boris Tichý, Nikola Tom, Elena Vallespin Garcia, Suman Verma, Kimbley Walker, Charles Wang, Junwen Wang, Yexun Wang, Zhining Wen, Valtteri Wirta, Leihong Wu, Chunlin Xiao, Wenzhong Xiao, Shibei Xu, Mary Yang, Jianming Ying, Shun H. Yip, Guangliang Zhang, Sa Zhang, Meiru Zhao, Yuanting Zheng, Xiaoyan Zhou, Christopher E. Mason, Timothy Mercer, Weida Tong, Leming Shi, Wendell Jones, Joshua Xu

Publikováno v: Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)

Abstract Background Targeted sequencing using oncopanels requires comprehensive assessments of accuracy and detection sensitivity to ensure analytical validity. By employing reference materials characterized by the U.S. Food and Drug Administration-l

Externí odkaz: https://doaj.org/article/c5365bb671514dddbb3d5b324f62ed28

Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology

Autor: Agda Karina Eterovic, Rebecca Ringler, Binsheng Gong, Jiashi Wang, Christopher E. Mason, Garima Kushwaha, Abhisek Ghosal, James C. Willey, Zhihong Zhang, Wenzhong Xiao, Natalia Novoradovskaya, Joshua Xu, Mary Yang, Zhiguang Li, Leihong Wu, Philippe Szankasi, Paul Rindler, Suman Verma, Simon Cawley, Daniel Stetson, Yilin Zhang, Fergal Casey, Nathan Haseley, Fujun Qiu, Paula Proszek, Mirna Jarosz, Ira W. Deveson, Kevin Lai, Donald J. Johann, Rebecca Kusko, Haowen Tan, Tim R. Mercer, Chia Jung Chang, Kristina Giorda, Tieliu Shi, Blake Burgher, Kyle Horvath, Leming Shi, Pierre R. Bushel, Guangchun Chen, Melissa Smith, Igor Stevanovski, Devin W. Close, Liang Feng, Lin-ya Tang, Liang-Chun Liu, Todd Richmond, Wendell D. Jones, Daniel Duncan, Andreas Scherer, Jorge Dinis, Chang Xu, Rita Shaknovich, Tom Morrison, Ping Song, Nikola Tom, Weida Tong, Quan Zhen Li, Lihyun Sun, Charles Ma, Dalila B. Megherbi, Robert Sebra, Sean Glenn, Narasimha Marella, Ambica Bhandari, Jennifer S. LoCoco, Zhichao Liu, Jeoffrey Schageman, Mehdi Pirooznia, Scott Happe, Hanane Arib, Maya Strahl, Dan Li, Hunter Best, Venkat J. Thodima, Amelia Raymond, Jeffrey Conroy, Mike Hubank, Piotr A. Mieczkowski, Carlos Pabón-Peña, James Blackburn, Li-Yuan Hung, Sa Zhang, Bindu Swapna Madala, Guangliang Zhang, Jonathan Choi

Publikováno v: Nature biotechnology

Circulating tumor DNA (ctDNA) sequencing is being rapidly adopted in precision oncology, but the accuracy, sensitivity, and reproducibility of ctDNA assays is poorly understood. Here we report the findings of a multi-site, cross-platform evaluation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3d76ae77be6b6d242d19ba6f29eaf8
http://europepmc.org/articles/PMC8434938

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Effect of masupirdine (SUVN‐502) on cognition in patients with moderate Alzheimer's disease: A randomized, double‐blind, phase 2, proof‐of‐concept study

Autor: Ramakrishna Nirogi, John Ieni, Vinod Kumar Goyal, Jyothsna Ravula, Satish Jetta, Anil Shinde, Pradeep Jayarajan, Vijay Benade, Veera Raghava Chowdary Palacharla, Dhanunjay Kumar Dogiparti, Venkat Jasti, Alireza Atri, Jeffrey Cummings

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)

Abstract Introduction This study explored the efficacy and safety of a serotonin‐6 receptor antagonist, masupirdine, as adjunct treatment in patients with moderate Alzheimer's disease (AD) concomitantly treated with donepezil and memantine. Methods

Externí odkaz: https://doaj.org/article/2946c8a2c70042bc98555d45982352fa

Safety and immunogenicity of the killed bivalent (O1 and O139) whole-cell cholera vaccine in the Philippines

Autor: Maria Rosario Z. Capeding, Maria Liza Antoinette M. Gonzales, Mandeep Singh Dhingra, Naveena Aloysia D'Cor, Venkat Jayanth Midde, Badri Narayan Patnaik, Yaël Thollot, Eric Desauziers

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 13, Iss 10, Pp 2232-2239 (2017)

The killed bivalent (O1 and O139) whole cell oral cholera vaccine (OCV) (Shanchol™) was first licensed in India in 2009 and World Health Organization pre-qualified in 2011. We assessed the safety and immunogenicity of this OCV in the Philippines. T

Externí odkaz: https://doaj.org/article/f9a2de82951e4689aeb14d07f13f8328