Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Venita I. DeAlmeida"'
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Data from The Soluble Wnt Receptor Frizzled8CRD-hFc Inhibits the Growth of Teratocarcinomas In vivo
Autor: Bonnee Rubinfeld, Paul Polakis, Hartmut Koeppen, James A. Ernst, Li Miao, Venita I. DeAlmeida
Wnt signaling is important for normal cell proliferation and differentiation, and mutations in pathway components are associated with human cancers. Recent studies suggest that altered wnt ligand/receptor interactions might also contribute to human t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b75812bb6a52287564a23df499d76f9
https://doi.org/10.1158/0008-5472.c.6495494.v1
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3
Abstract 578: A functional approach to identifying and engineering TCRs results in highly-potent and specific TCRs for TCR-T cell therapy
Autor: John D. Leonard, Alejandro Ramirez, Jason Romero, Jake Kleiner, Joanna Dreux, Bindu Hegde, Bryan Xie, Akshay Sharathchandra, Nathan Katz, Venita I. DeAlmeida, Hans-Peter Gerber, Marvin H. Gee, Leah V. Sibener
Publikováno v: Cancer Research. 82:578-578
Peptide-HLA (pHLA)- targeting therapeutics, such as T cell receptor-engineered T cells (TCR-T), have had clinical success in treating solid tumors. However, challenges related to safety exist: major concerns remain surrounding the cross-reactivity of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2b73cf224f999d7de80b7d553614fc9
https://doi.org/10.1158/1538-7445.am2022-578
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4
Akademický článek
Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains.
Autor: Travis W Bainbridge, Venita I DeAlmeida, Anita Izrael-Tomasevic, Cécile Chalouni, Borlan Pan, Joshua Goldsmith, Alia P Schoen, Gabriel A Quiñones, Ryan Kelly, Jennie R Lill, Wendy Sandoval, Mike Costa, Paul Polakis, David Arnott, Bonnee Rubinfeld, James A Ernst
Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102695 (2014)
Receptor tyrosine kinase-like orphan receptors (ROR) 1 and 2 are atypical members of the receptor tyrosine kinase (RTK) family and have been associated with several human diseases. The vertebrate RORs contain an ATP binding domain that deviates from
Externí odkaz: https://doaj.org/article/080290e22e094a90849ffe90a71ec97c
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5
Akademický článek
Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies.
Autor: Yan Gong, Eric Bourhis, Cecilia Chiu, Scott Stawicki, Venita I DeAlmeida, Bob Y Liu, Khanhky Phamluong, Tim C Cao, Richard A D Carano, James A Ernst, Mark Solloway, Bonnee Rubinfeld, Rami N Hannoush, Yan Wu, Paul Polakis, Mike Costa
Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12682 (2010)
β-Catenin-dependent Wnt signaling is initiated as Wnt binds to both the receptor FZD and coreceptor LRP5/6, which then assembles a multimeric complex at the cytoplasmic membrane face to recruit and inactivate the kinase GSK3. The large number and se
Externí odkaz: https://doaj.org/article/e5991f379a5147a2b9b70b45b9ce3556
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6
Abstract 2250: STRO-002, an anti-FolRαADC, demonstrates immune-modulating properties and potentiates PD-L1 blockade
Autor: Shamim Ahmad, Sihong Zhou, Venita I. DeAlmeida, Cuong D. Tran, Trevor J. Hallam, Mark Lupher, Christine Cheng, Janice Yu, Jeffrey A. Hanson, Gang Yin, Krishna Bajjuri, Millicent Embry, Cristina Abrahams, Xioafan Li
Publikováno v: Cancer Research. 80:2250-2250
There is growing evidence that tumor-targeted cytotoxins can also enhance anti-tumor immunity by inducing immunogenic cell death (ICD) in tumor cells and promoting recruitment of immune effector cells. We sought to investigate the immune stimulating
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3da7443010b4ad1be91a92f8368d4d92
https://doi.org/10.1158/1538-7445.am2020-2250
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8
Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake
Autor: Xiaozhou Yang, Changzu Cai, Lili Qian, Sun-Young Jeong, Venita I. DeAlmeida, Pengfei Yuan, Michael R. Costa, Stanley N. Cohen, James A. Ernst, Wensheng Wei
Publikováno v: Science China Life Sciences. 57:469-481
LRP6, a co-receptor for the morphogen Wnt, aids endocytosis of anthrax complexes. Here we report that Dickkopf1 (DKK1) protein, a secreted LRP6 ligand and antagonist, is also a modulator of anthrax toxin sensitivity. shRNA-mediated gene silencing or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58488eacf692c54ac7fc275967282c36
https://doi.org/10.1007/s11427-014-4646-x
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10
The Soluble Wnt Receptor Frizzled8CRD-hFc Inhibits the Growth of Teratocarcinomas In vivo
Autor: James A. Ernst, Venita I. DeAlmeida, Li Miao, Bonnee Rubinfeld, Paul Polakis, Hartmut Koeppen
Publikováno v: Cancer Research. 67:5371-5379
Wnt signaling is important for normal cell proliferation and differentiation, and mutations in pathway components are associated with human cancers. Recent studies suggest that altered wnt ligand/receptor interactions might also contribute to human t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c7ec4bf104276abacfdfaf1c0819cd
https://doi.org/10.1158/0008-5472.can-07-0266
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