Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Venigalla B. Rao"'
Autor:
Shuangshuang Wang, Sirong Kuang, Haiguang Song, Erchao Sun, Mengling Li, Yuepeng Liu, Ziwei Xia, Xueqi Zhang, Xialin Wang, Jiumin Han, Venigalla B. Rao, Tingting Zou, Chen Tan, Pan Tao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Toll/interleukin-1 receptor (TIR) domain-containing proteins play a critical role in immune responses in diverse organisms, but their function in bacterial systems remains to be fully elucidated. This study, focusing on Escherichia coli, add
Externí odkaz:
https://doaj.org/article/3c6094c783024482a56a2992adfefd48
Autor:
Jérémie Prévost, Yaozong Chen, Fei Zhou, William D. Tolbert, Romain Gasser, Halima Medjahed, Manon Nayrac, Dung N. Nguyen, Suneetha Gottumukkala, Ann J. Hessell, Venigalla B. Rao, Edwin Pozharski, Rick K. Huang, Doreen Matthies, Andrés Finzi, Marzena Pazgier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The HIV-1 entry inhibitor temsavir prevents the viral receptor CD4 (cluster of differentiation 4) from interacting with the envelope glycoprotein (Env) and blocks its conformational changes. To do this, temsavir relies on the presence of a r
Externí odkaz:
https://doaj.org/article/5ca0ee97820f4768be0d20e9dea09bbe
Autor:
Jingen Zhu, Himanshu Batra, Neeti Ananthaswamy, Marthandan Mahalingam, Pan Tao, Xiaorong Wu, Wenzheng Guo, Andrei Fokine, Venigalla B. Rao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Designing artificial viral vectors (AVVs) programmed with biomolecules that can enter human cells and carry out molecular repairs will have broad applications. Here, we describe an assembly-line approach to build AVVs by engineering the well
Externí odkaz:
https://doaj.org/article/f876df16271b41faa46a7605e13a1ee3
Autor:
Li Dai, Digvijay Singh, Suoang Lu, Vishal I. Kottadiel, Reza Vafabakhsh, Marthandan Mahalingam, Yann R. Chemla, Taekjip Ha, Venigalla B. Rao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
In viruses, multi-subunit ring-ATPases are involved in genome packaging. Here, using single-molecule techniques, the authors determine that the active bacteriophage T4 DNA packaging motor is a pentamer and show that the motor can tolerate inactive su
Externí odkaz:
https://doaj.org/article/0b529d51539e44cd8a86334c5969b133
Autor:
Andrei Fokine, Mohammad Zahidul Islam, Qianglin Fang, Zhenguo Chen, Lei Sun, Venigalla B. Rao
Publikováno v:
Viruses, Vol 15, Iss 7, p 1517 (2023)
Bacteriophage T4 is decorated with 155 180 Å-long fibers of the highly antigenic outer capsid protein (Hoc). In this study, we describe a near-atomic structural model of Hoc by combining cryo-electron microscopy and AlphaFold structure predictions.
Externí odkaz:
https://doaj.org/article/8fdf11febe3747618ae1031ef06bf1e5
Autor:
Jingen Zhu, Swati Jain, Jian Sha, Himanshu Batra, Neeti Ananthaswamy, Paul B. Kilgore, Emily K. Hendrix, Yashoda M. Hosakote, Xiaorong Wu, Juan P. Olano, Adeyemi Kayode, Cristi L. Galindo, Simran Banga, Aleksandra Drelich, Vivian Tat, Chien-Te K. Tseng, Ashok K. Chopra, Venigalla B. Rao
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The U.S. Food and Drug Administration-authorized mRNA- and adenovirus-based SARS-CoV-2 vaccines are intramuscularly injected in two doses and effective in preventing COVID-19, but they do not induce efficient mucosal immunity or prevent vira
Externí odkaz:
https://doaj.org/article/bce3c0d8931d4e4fb22673c9a20b9eda
Autor:
Qianglin Fang, Wei-Chun Tang, Pan Tao, Marthandan Mahalingam, Andrei Fokine, Michael G. Rossmann, Venigalla B. Rao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
In icosahedral viruses, a symmetry-mismatched portal vertex is assembled by inserting a 12-fold-symmetric portal complex into a 5-fold-symmetric capsid environment. Here, the authors report a near-atomic-resolution in situ cryo-electron microscopy st
Externí odkaz:
https://doaj.org/article/2e90a65facef4cc4a9de0b77b96d9c46
Publikováno v:
Viruses, Vol 15, Iss 2, p 527 (2023)
Bacteriophage (phage) T4 has served as an extraordinary model to elucidate biological structures and mechanisms. Recent discoveries on the T4 head (capsid) structure, portal vertex, and genome packaging add a significant body of new literature to pha
Externí odkaz:
https://doaj.org/article/bd53935eff41410c93c0012e0823932c
Autor:
Mengling Li, Pengju Guo, Cen Chen, Helong Feng, Wanpo Zhang, Changqin Gu, Guoyuan Wen, Venigalla B. Rao, Pan Tao
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Developing influenza vaccines that protect against a broad range of viruses is a global health priority. Several conserved viral proteins or domains have been identified as promising targets for such vaccine development. However, none of the targets
Externí odkaz:
https://doaj.org/article/dea037f2d4484db1b56c994f888dd2a4
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Bacteriophages (phages) are viruses that infect bacteria and use them as replication factories to assemble progeny phages. Bacteria have evolved powerful defense mechanisms to destroy the invading phages by severing their genomes soon after entry int
Externí odkaz:
https://doaj.org/article/aa2042bee2a0440da6879666dfe0d35f