Serum proteome modulations upon treatment provides biological insight on response to treatment in relapsed mantle cell lymphoma

Autor: Lavanya Lokhande, Venera Kuci Emruli, Christian Winther Eskelund, Arne Kolstad, Martin Hutchings, Riikka Räty, Carsten Utoft Niemann, Kirsten Grønbæk, Mats Jerkeman, Sara Ek

Publikováno v: Cancer Reports, Vol 5, Iss 7, Pp n/a-n/a (2022)

Abstract Background The possibility to monitor patient's serum proteome during treatment can provide deepened understanding of the biology associated with response to specific drugs. Non‐invasive serum sampling provides an opportunity for sustainab

Externí odkaz: https://doaj.org/article/7631cd50529f493cbd46cd934cda28fd

Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity

Autor: Catja Freiburghaus, Venera Kuci Emruli, Angelica Johansson, Christian Winther Eskelund, Kirsten Grønbæk, Roger Olsson, Fredrik Ek, Mats Jerkeman, Sara Ek

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-17 (2018)

Abstract Background The addition of high-dose cytarabine to the treatment of mantle cell lymphoma (MCL) has significantly prolonged survival of patients, but relapses are common and are normally associated with increased resistance. To elucidate the

Externí odkaz: https://doaj.org/article/a48002ef2c2f4595992abace3e2ffc4b

Immune-related protein signature in serum stratify relapsed mantle cell lymphoma patients based on risk

Autor: Arne Kolstad, Riikka Räty, Lavanya Lokhande, Martin Hutchings, Venera Kuci Emruli, Mats Jerkeman, Sara Ek

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
BMC Cancer

Background Response to modern treatment strategies, which combine cytotoxic compounds with immune stimulatory agents and targeted treatment is highly variable among MCL patients. Thus, providing prognostic and predictive markers for risk adapted ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7962ab4b5e6b386288f913648c1e2fc9
https://doaj.org/article/0dd0f9b0ee1544eab0e01e96761fb1a1

Identification of a serum biomarker signature associated with metastatic prostate cancer

Autor: Ulrika Axelsson, Lisa Theorin, Venera Kuci Emruli, David E. Neal, Hans Lilja, Carl A.K. Borrebaeck, Jenny L Donovan, Anders Bjartell, Leena Liljedahl, Freddie C. Hamdy, Corinna Richter

Publikováno v: Proteomics Clin Appl
Emruli, V K, Liljedahl, L, Axelsson, U, Richter, C, Theorin, L, Bjartell, A, Lilja, H, Donovan, J, Neal, D, Hamdy, F C & Borrebaeck, C A K 2021, ' Identification of a serum biomarker signature associated with metastatic prostate cancer ', Proteomics-Clinical applications, vol. 15, no. 2-3, 2000025 . https://doi.org/10.1002/prca.202000025

Purpose Improved early diagnosis and determination of aggressiveness of prostate cancer (PC) is important to select suitable treatment options and to decrease over-treatment. The conventional marker is total prostate specific antigen (PSA) levels in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed6df37a9c8d999c94e92b9ed925f05
https://europepmc.org/articles/PMC9310707/

Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity

Autor: Kirsten Grønbæk, Sara Ek, Venera Kuci Emruli, Christian Winther Eskelund, Roger Olsson, Fredrik Ek, Angelica Johansson, Mats Jerkeman, Catja Freiburghaus

Publikováno v: BMC Cancer
Freiburghaus, C, Emruli, V K, Johansson, A, Eskelund, C W, Grønbæk, K, Olsson, R, Ek, F, Jerkeman, M & Ek, S 2018, ' Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity ', BMC Cancer, vol. 18, no. 1, 466 . https://doi.org/10.1186/s12885-018-4346-1
BMC Cancer, Vol 18, Iss 1, Pp 1-17 (2018)

Background The addition of high-dose cytarabine to the treatment of mantle cell lymphoma (MCL) has significantly prolonged survival of patients, but relapses are common and are normally associated with increased resistance. To elucidate the mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80f56e633be9f10409d3704e33eb842
http://europepmc.org/articles/PMC5918903