Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Vendula Sepsova"'
Autor:
Youssef Dgachi, Hélène Martin, Rim Malek, Daniel Jun, Jana Janockova, Vendula Sepsova, Ondrej Soukup, Isabel Iriepa, Ignacio Moraleda, Emna Maalej, M. Carmo Carreiras, Bernard Refouvelet, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 163-170 (2019)
In view of the multifactorial nature of Alzheimer’s disease (AD), multitarget small molecules (MTSM) represent the most potent and attractive therapeutic strategy to design new drugs for Alzheimer’s disease therapy. The new MTSM KojoTacrines (KTs
Externí odkaz:
https://doaj.org/article/e3c0e08c463645d08a8cc7dd58a4bda9
Autor:
Jan Korabecny, Martin Andrs, Eugenie Nepovimova, Rafael Dolezal, Katerina Babkova, Anna Horova, David Malinak, Eva Mezeiova, Lukas Gorecki, Vendula Sepsova, Martina Hrabinova, Ondrej Soukup, Daniel Jun, Kamil Kuca
Publikováno v:
Molecules, Vol 20, Iss 12, Pp 22084-22101 (2015)
Alzheimer’s disease (AD) is a debilitating progressive neurodegenerative disorder that ultimately leads to the patient’s death. Despite the fact that novel pharmacological approaches endeavoring to block the neurodegenerative process are still em
Externí odkaz:
https://doaj.org/article/0c1bebafcb9c40c69dde513c28fd02e1
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 8, Pp 16076-16086 (2013)
Acetylcholinesterase (AChE) reactivators (oximes) are compounds predominantly targeting the active site of the enzyme. Toxic effects of organophosphates nerve agents (OPNAs) are primarily related to their covalent binding to AChE and butyrylcholinest
Externí odkaz:
https://doaj.org/article/3acc1c094aa445219a879a37d3821779
Autor:
Kamil Kuca, Brian J. Bennion, Rafael Dolezal, Filip Zemek, Vendula Sepsova, Jana Zdarova Karasova, Jan Korabecny
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 8, Pp 16882-16900 (2013)
Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate intoxication. Standard care involves the use of anticonvulsants (e.g., diazepam), parasympatolytics (e.g., atropine) and oximes that restore AChE activity. H
Externí odkaz:
https://doaj.org/article/e19b4f37d9ec4d0297c7104bfe17610c
Autor:
Jiri Kassa, Jan Misik, Jana Hatlapatkova, Jana Zdarova Karasova, Vendula Sepsova, Filip Caisberger, Jaroslav Pejchal
Publikováno v:
Molecules, Vol 22, Iss 7, p 1152 (2017)
The ability of two newly developed oximes (K305, K307) to protect tabun-poisoned rats from tabun-induced inhibition of brain acetylcholinesterase, acute neurotoxic signs and symptoms and brain damage was compared with that of the oxime K203 and trime
Externí odkaz:
https://doaj.org/article/ceeec9c8670e41628d6d0d9f3d1844fe
Autor:
Eva Mezeiova, Jan Korabecny, Vendula Sepsova, Martina Hrabinova, Petr Jost, Lubica Muckova, Tomas Kucera, Rafael Dolezal, Jan Misik, Katarina Spilovska, Ngoc Lam Pham, Lucia Pokrievkova, Jaroslav Roh, Daniel Jun, Ondrej Soukup, Daniel Kaping, Kamil Kuca
Publikováno v:
Molecules, Vol 22, Iss 8, p 1265 (2017)
Tacrine (THA), the first clinically effective acetylcholinesterase (AChE) inhibitor and the first approved drug for the treatment of Alzheimer’s disease (AD), was withdrawn from the market due to its side effects, particularly its hepatotoxicity. N
Externí odkaz:
https://doaj.org/article/fe0fff597e6d4ec9a5efe54879c94f4d
Autor:
Eva Novotná, Martin Vališ, Kamil Kuca, Ondrej Soukup, Jaroslav Pejchal, Eva Vodakova, Kamil Musilek, Jana Zdarova Karasova, Daniel Jun, Vendula Sepsova, Jiri Kassa, Anna Horova, Martina Hrabinova, Eugenie Nepovimova
Publikováno v:
Drug Design, Development and Therapy
Kamil Kuca,1,2 Jana Zdarova Karasova,2,3 Ondrej Soukup,2 Jiri Kassa,3 Eva Novotna,2 Vendula Sepsova,2,3 Anna Horova,2 Jaroslav Pejchal,3 Martina Hrabinova,2,3 Eva Vodakova,2 Daniel Jun,2,3 Eugenie Nepovimova,1,2 Martin Valis,4 Kamil Musilek1,2 1Depar
Autor:
Jana Janockova, Ondrej Soukup, Daniel Jun, Mourad Chioua, José Marco-Contelles, Ignacio Moraleda, Lhassane Ismaili, Vendula Sepsova, Fakher Chabchoub, Isabel Iriepa, Hélène Martin, Youssef Dgachi, Estefanía Serrano
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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In this report we describe the synthesis, biological evaluation and molecular modeling of new tacrine analogues such as QuinoPyranTacrines (QPTs), designed by juxtaposition of 1,4- naphthoquinone and tacrine. From these results we have identified QPT
Publikováno v:
Journal of Applied Biomedicine. 15:49-53
The reactivating and therapeutic efficacy of two newly developed oximes (K305, K307) was compared with the oxime K203 and trimedoxime using in vivo methods The study determining percentage of reactivation of tabun-inhibited acetylcholinesterase in th
Autor:
Ondrej Soukup, Patrik Poprac, Vlasta Brezová, Zuzana Bednarikova, Klaudia Jomová, Peter Lauro, Daniel Jun, Slavka Hamulakova, Zuzana Gazova, Martina Hrabinova, Kamil Kuca, Vendula Sepsova, Pavol Kristian, Lenka Drostinova, Marian Valko
Publikováno v:
Journal of Inorganic Biochemistry. 161:52-62
Alzheimer's disease is a multifactorial disease that is characterized mainly by Amyloid-β (A-β) deposits, cholinergic deficit and extensive metal (copper, iron)-induced oxidative stress. In this work we present details of the synthesis, antioxidant