Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Vendula Hepnarova"'
Autor:
David Malinak, Rafael Dolezal, Vendula Hepnarova, Miroslava Hozova, Rudolf Andrys, Petr Bzonek, Veronika Racakova, Jan Korabecny, Lukas Gorecki, Eva Mezeiova, Miroslav Psotka, Daniel Jun, Kamil Kuca, Kamil Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE
Externí odkaz:
https://doaj.org/article/4eaa3b83e7db43c89b59bdfb119cb77b
Autor:
Barbora Svobodova, Eva Mezeiova, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Tereza Kobrlova, Daniel Jun, Ondrej Soukup, María Luisa Jimeno, José Marco-Contelles, Jan Korabecny
Publikováno v:
Biomolecules, Vol 9, Iss 8, p 379 (2019)
Tacrine was the first drug to be approved for Alzheimer’s disease (AD) treatment, acting as a cholinesterase inhibitor. The neuropathological hallmarks of AD are amyloid-rich senile plaques, neurofibrillary tangles, and neuronal degeneration. The p
Externí odkaz:
https://doaj.org/article/fb20ff896efd4e35bc8a5bbdbb1a00d4
Autor:
Jana Janockova, Rafael Dolezal, Eugenie Nepovimova, Tereza Kobrlova, Marketa Benkova, Kamil Kuca, Jan Konecny, Eva Mezeiova, Michaela Melikova, Vendula Hepnarova, Avi Ring, Ondrej Soukup, Jan Korabecny
Publikováno v:
Molecules, Vol 23, Iss 11, p 2926 (2018)
The neuropeptides, orexin A and orexin B (also known as hypocretins), are produced in hypothalamic neurons and belong to ligands for orphan G protein-coupled receptors. Generally, the primary role of orexins is to act as excitatory neurotransmitters
Externí odkaz:
https://doaj.org/article/5d196cdbcad34cc5a090e956de18bdd5
Autor:
Barbora Svobodova, Lenka Pulkrabkova, Dawid Panek, Anna Misiachna, Marharyta Kolcheva, Rudolf Andrys, Jiri Handl, Jan Capek, Pavlina Nyvltova, Tomas Rousar, Lukas Prchal, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Daniela Tosnerova, Galina Karabanovich, Vladimir Finger, Ondrej Soukup, Martin Horak, Jan Korabecny
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9124
Alzheimer’s disease (AD) is a complex disease with an unknown etiology. Available treatments, limited to cholinesterase inhibitors and N-methyl-d-aspartate receptor (NMDAR) antagonists, provide symptomatic relief only. As single-target therapies ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cb799254ac08c27aef258d2c563f51
https://ruj.uj.edu.pl/xmlui/handle/item/312616
https://ruj.uj.edu.pl/xmlui/handle/item/312616
Autor:
Vendula Hepnarova, Slavka Hamulakova, Jan Korabecny, Ondrej Soukup, Roman Mezencev, Ladislav Janovec, Martina Hrabinova, Veronika Ihnatova, Yury O. Chernoff, Zachery J. Deckner, Nikola Novakova, Zuzana Kudličková, Kamil Kuca, Petr Bzonek, Jana Janockova, Daniel Jun
Publikováno v:
Future Med Chem
The authors report on the synthesis and biological evaluation of new compounds whose structure combines tacrine and indole moieties. Tacrine–indole heterodimers were designed to inhibit cholinesterases and β-amyloid formation, and to cross the blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231391952a0a73e9b4c1dac19dbb330c
https://doi.org/10.4155/fmc-2020-0184
https://doi.org/10.4155/fmc-2020-0184
Autor:
Daniel Jun, Eva Mezeiova, Rudolf Andrys, Jan Korabecny, Lukas Gorecki, Kamil Musilek, David Malinak, Miroslava Hozova, Veronika Racakova, Petr Bzonek, Kamil Kuca, Miroslav Psotka, Vendula Hepnarova, Rafael Dolezal
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5c2dccaa60abd51ca9c69bd7bb9046
http://europepmc.org/articles/PMC6968506
http://europepmc.org/articles/PMC6968506
Autor:
Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Tomas Kucera, Monika Schmidt, Rafael Dolezal, Lukas Gorecki, Veronika Hrabcova, Jan Korabecny, Eva Mezeiova, Daniel Jun, Jaroslav Pejchal
Publikováno v:
Toxicology in Vitro. 85:105463
Insecticides represent the most crucial element in the integrated management approach to malaria and other vector-borne diseases. The evolution of insect resistance to long-used substances and the toxicity of organophosphates (OPs) and carbamates are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4481c132ad3783fcc800d45da09ab056
https://doi.org/10.1016/j.tiv.2022.105463
https://doi.org/10.1016/j.tiv.2022.105463
Autor:
Jaroslav Pejchal, Jiří Kassa, Filip Caisberger, Vendula Hepnarova, Jana Žďárová Karasová, Jana Hatlapatková
Publikováno v:
Acta Medica, Vol 64, Iss 3, Pp 145-152 (2021)
Aim: The comparison of neuroprotective and central reactivating effects of the oxime K870 in combination with atropine with the efficacy of standard antidotal treatment in tabun-poisoned rats. Methods: The neuroprotective effects of antidotal treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ea4d69a081acbcc9bf865775ec9d0a
https://pubmed.ncbi.nlm.nih.gov/34779379
https://pubmed.ncbi.nlm.nih.gov/34779379
Autor:
Jana Zdarova Karasova, Jiri Kassa, Vendula Hepnarova, Jaroslav Pejchal, Lucie Junova, Rudolf Andrys, David Malinak, Petr Bzonek, Zuzana Kohoutova, Kamil Musilek
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 167
Oxime reactivators are causal antidotes for organophosphate intoxication. Herein, the toxicity, pharmacokinetics, and reactivation effectiveness of o-chlorinated bispyridinium oxime K870 are reported. Oxime K870 was found to have a safe profile at a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a336d0a9350d76a52c79f0aff00f31b
https://pubmed.ncbi.nlm.nih.gov/35738326
https://pubmed.ncbi.nlm.nih.gov/35738326
Autor:
Ondrej Soukup, Martina Kaniakova, Tomas Kucera, Vendula Hepnarova, Martin Horak, Jan Korabecny, Karel Vales, Tereza Kobrlova, Eugenie Nepovimova, Kristina Holubova, Kristyna Skrenkova, Lenka Kleteckova, Zofia Chrienova
Publikováno v:
Current Alzheimer Research. 16:821-833
Background: Alzheimer’s disease (AD) is the most common form of dementia in the elderly. It is characterized as a multi-factorial disorder with a prevalent genetic component. Due to the unknown etiology, current treatment based on acetylcholinester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359004126134411738d964f70b5472cb
https://doi.org/10.2174/1567205016666190228122218
https://doi.org/10.2174/1567205016666190228122218