Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes.

Autor: Yin JA; Institute of Neuropathology, University of Zurich, Zurich, Switzerland. jiang-an.yin@uzh.ch., Frick L; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Scheidmann MC; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland., Liu T; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Trevisan C; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Dhingra A; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Spinelli A; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Wu Y; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Yao L; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Vena DL; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Knapp B; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland., Guo J; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., De Cecco E; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Ging K; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Armani A; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.; Department of Biomedical Sciences, University of Padua, Padova, Italy., Oakeley EJ; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland., Nigsch F; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland., Jenzer J; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland., Haegele J; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland., Pikusa M; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland., Täger J; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Rodriguez-Nieto S; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Bouris V; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Ribeiro R; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Baroni F; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Bedi MS; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland., Berry S; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.; EMBL Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney, Australia., Losa M; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Hornemann S; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Kampmann M; Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA., Pelkmans L; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Hoepfner D; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland., Heutink P; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Aguzzi A; Institute of Neuropathology, University of Zurich, Zurich, Switzerland. adriano.aguzzi@uzh.ch.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2024 Dec 04. Date of Electronic Publication: 2024 Dec 04.