The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial

Autor: Marson, Anthony, Burnside, Girvan, Appleton, Richard, Smith, Dave, Leach, John Paul, Sills, Graeme, Tudur-Smith, Catrin, Plumpton, Catrin, Hughes, Dyfrig A, Williamson, Paula, Baker, Gus A, Balabanova, Silviya, Taylor, Claire, Brown, Richard, Hindley, Dan, Howell, Stephen, Maguire, Melissa, Mohanraj, Rajiv, Smith, Philip E, Lanyon, Karen, Manford, Mark, Chitre, Manali, Parker, Alasdair, Swiderska, Nina, Pauling, James, Hughes, Adrian, Gupta, Rajat, Hanif, Sadia, Awadh, Mostafa, Ragunathan, Sharmini, Cable, Nicola, Cooper, Paul, Hindley, Daniel, Rakshi, Karl, Molloy, Sophie, Reuber, Markus, Ayonrinde, Kunle, Wilson, Martin, Saladi, Satyanarayana, Gibb, John, Funston, Lesley-Ann, Cassidy, Damhait, Boyd, Jonathan, Ratnayaka, Mal, Faza, Hani, Sadler, Martin, Al-Moasseb, Hassan, Galtrey, Clare, Wren, Damien, Olabi, Anas, Fuller, Geraint, Khan, Muhammed, Kallappa, Chetana, Chinthapalli, Ravi, Aji, Baba, Davies, Rhys, Foster, Kathryn, Hitiris, Nikolas, Hussain, Nahin, Dowson, Simon, Ellison, Julie, Sharrack, Basil, Gandhi, Vandna, Powell, Rob, Tittensor, Phil, Summers, Beatrice, Shashikiran, Sastry, Dison, Penelope J, Samarasekera, Shanika, McCorry, Doug, White, Kathleen, Nithi, Kannan, Richardson, Martin, Page, Rupert, Deekollu, David, Slaght, Sean, Warriner, Stephen, Ahmed, Mansoor, Chaudhuri, Abhijit, Chow, Gabriel, Artal, Javier, Kucinskiene, Danute, Sreenivasa, Harish, Velmurugan, Singara, Zipitis, Christos S, McLean, Brendan, Lal, Vaithianathar, Gregoriou, Angelous, Maddison, Paul, Pickersgill, Trevor, Anderson, Joseph, Lawthom, Charlotte, Whitlingum, Gabriel, Rakowicz, Wojtek, Kinton, Lucy, McLellan, Alisa, Vora, Nitish, Zuberi, Sameer, Kelso, Andrew, Hughes, Imelda, Martland, John, Emsley, Hedley, de Goede, Christian, Singh, RP, Moor, Carl-Christian, Aram, Julia, Sakthivel, Kumar, Nelapatla, Suresh, Rittey, Chris, Pinto, Ashwin, Cock, Hannah, Richardson, Anna, Houston, Erika, Cooper, Christopher, Lawson, Geoff, Massarano, Albert, Burness, Christine, Wieshmann, Udo, Dey, Indranil, Sivakumar, Puthuval, Yeung, Lap-Kong, Smith, Philip, Bentur, Hemalata, Heafield, Tom, Mathew, Anna, Smith, David, Jauhari, Praveen

Publikováno v: Mohanraj, R 2021, ' The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. ', Lancet (London, England) . https://doi.org/10.1016/s0140-6736(21)00246-4
Lancet (London, England)

Background: \ud Valproate is a first-line treatment for patients with newly diagnosed idiopathic generalised or difficult to classify epilepsy, but not for women of child-bearing potential because of teratogenicity. Levetiracetam is increasingly pres

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https://eprints.gla.ac.uk/238444/1/238444.pdf