Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Vello Tõugu"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Alzheimer’s disease (AD) is characterized by classic hallmarks such as amyloid plaques and neurofibrillary tangles, however, intensive research has broadened its scope to explore additional underlying mechanisms. Notably, disruptions in metal homeo
Externí odkaz:
https://doaj.org/article/ad55e552c9a24eb28a0ef2d8b067ce10
Autor:
Andra Noormägi, Tatjana Golubeva, Elina Berntsson, Sebastian K.T.S. Wärmländer, Vello Tõugu, Peep Palumaa
Publikováno v:
ACS Omega, Vol 8, Iss 37, Pp 33912-33919 (2023)
Externí odkaz:
https://doaj.org/article/7d3bb9c4fc014b58950f3a893ebec7ed
Publikováno v:
FEBS Open Bio, Vol 10, Iss 6, Pp 1072-1081 (2020)
Diethyl pyrocarbonate (DEPC) has been primarily used as a residue‐specific modifying agent to study the role of His residues in peptide/protein and enzyme function; however, its action is not specific, and several other residues can also be modifie
Externí odkaz:
https://doaj.org/article/47426dc587d8465c9013505a65522eac
Autor:
Julia Smirnova, Julia Gavrilova, Andra Noormägi, Karin Valmsen, Hegne Pupart, Jinghui Luo, Vello Tõugu, Peep Palumaa
Publikováno v:
Molecules, Vol 27, Iss 10, p 3160 (2022)
The tight binding of Cu and Zn ions to superoxide dismutase 1 (SOD1) maintains the protein stability, associated with amyotrophic lateral sclerosis (ALS). Yet, the quantitative studies remain to be explored for the metal-binding affinity of wild-type
Externí odkaz:
https://doaj.org/article/ecf9baf0e71d4ec49be0493fac5d34c1
Autor:
Julia Smirnova, Ekaterina Kabin, Ivar Järving, Olga Bragina, Vello Tõugu, Thomas Plitz, Peep Palumaa
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Wilson disease is an autosomal recessive genetic disorder caused by loss-of-function mutations in the P-type copper ATPase, ATP7B, which leads to toxic accumulation of copper mainly in the liver and brain. Wilson disease is treatable, primar
Externí odkaz:
https://doaj.org/article/5d926ca94e3f422baf2d72ab51c8f33f
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186636 (2017)
The progression of Alzheimer's disease is causatively linked to the accumulation of amyloid-β aggregates in the brain, however, it is not clear how the amyloid aggregates initiate the death of neuronal cells. The in vitro toxic effects of amyloid pe
Externí odkaz:
https://doaj.org/article/dec06ae66a84460fbba8c3c4d0553b63
Publikováno v:
AIP Advances, Vol 5, Iss 9, Pp 092401-092401-12 (2015)
The amyloid deposition in the form of extracellular fibrillar aggregates of amyloid-β (Aβ) peptide is a critical pathological event in Alzheimer’s disease. Here, we report a systematic investigation of the effects of environmental factors on the
Externí odkaz:
https://doaj.org/article/69d67a7da20d4539bc0b308d3c06151a
Autor:
Elina Berntsson, Merlin Sardis, Andra Noormägi, Jüri Jarvet, Per M. Roos, Vello Tõugu, Astrid Gräslund, Peep Palumaa, Sebastian K. T. S. Wärmländer
Publikováno v:
ACS Omega. 7:28924-28931
Mercury intoxication typically produces more severe outcomes in people with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e360c87087de8440d82f0175825eb75
https://doi.org/10.1021/acsomega.2c02254
https://doi.org/10.1021/acsomega.2c02254
Autor:
Elina Berntsson, Faraz Vosough, Andra Noormägi, Kärt Padari, Fanny Asplund, Maciej Gielnik, Suman Paul, Jüri Jarvet, Vello Tõugu, Per M. Roos, Maciej Kozak, Astrid Gräslund, Andreas Barth, Margus Pooga, Peep Palumaa, Sebastian K. T. S. Wärmländer
Uranium (U) is naturally present in ambient air, water, and soil, and depleted uranium (DU) is released into the environment via industrial and military activities. While the radiological damage from U is rather well understood, less is known about t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c13d8606b32d5851a222645bba582bd
https://doi.org/10.1101/2023.03.29.534802
https://doi.org/10.1101/2023.03.29.534802
Autor:
Julia, Smirnova, Julia, Gavrilova, Andra, Noormägi, Karin, Valmsen, Hegne, Pupart, Jinghui, Luo, Vello, Tõugu, Peep, Palumaa
Publikováno v:
Molecules (Basel, Switzerland). 27(10)
The tight binding of Cu and Zn ions to superoxide dismutase 1 (SOD1) maintains the protein stability, associated with amyotrophic lateral sclerosis (ALS). Yet, the quantitative studies remain to be explored for the metal-binding affinity of wild-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbf4909c64ab6bce6febfef83e841c59
https://pubmed.ncbi.nlm.nih.gov/35630637
https://pubmed.ncbi.nlm.nih.gov/35630637