Functional Antagonism of Junctional Adhesion Molecule-A (JAM-A), Overexpressed in Breast Ductal Carcinoma In Situ (DCIS), Reduces HER2-Positive Tumor Progression.

Autor: Smith YE; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Wang G; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Flynn CL; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Madden SF; Data Science Centre, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland., MacEneaney O; Department of Pathology, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Cruz RGB; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Richards CE; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Jahns H; School of Veterinary Medicine, University College Dublin, Dublin 4, Ireland., Brennan M; School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland., Cremona M; Department of Medical Oncology, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Hennessy BT; Department of Medical Oncology, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Sheehan K; Department of Pathology, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Casucci A; School of Medicine, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland., Sani FA; School of Medicine, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland., Hudson L; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Fay J; Department of Pathology, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Vellanki SH; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., O'Flaherty S; Department of Chemistry, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland., Devocelle M; Department of Chemistry, RCSI University of Medicine and Health Sciences, Dublin 2, Ireland., Hill ADK; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Brennan K; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland., Sukumar S; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Hopkins AM; Department of Surgery, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Dublin 9, Ireland.

Publikováno v: Cancers [Cancers (Basel)] 2022 Mar 03; Vol. 14 (5). Date of Electronic Publication: 2022 Mar 03.

Antibiotic Tetrocarcin-A Down-regulates JAM-A, IAPs and Induces Apoptosis in Triple-negative Breast Cancer Models.

Autor: Vellanki SH; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland., Cruz RGB; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland., Richards CE; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland., Smith YE; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland., Hudson L; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland., Jahns H; Pathobiology Section, School of Veterinary Medicine, University College Dublin, Dublin, Ireland., Hopkins AM; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland annhopkins@rcsi.ie.

Publikováno v: Anticancer research [Anticancer Res] 2019 Mar; Vol. 39 (3), pp. 1197-1204.

Cleavage of the extracellular domain of junctional adhesion molecule-A is associated with resistance to anti-HER2 therapies in breast cancer settings.

Autor: Leech AO; Department of Surgery, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland., Vellanki SH; Department of Surgery, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland., Rutherford EJ; Department of Surgery, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland., Keogh A; Department of Surgery, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland., Jahns H; Pathobiology Section, School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland., Hudson L; Department of Surgery, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland., O'Donovan N; National Institute for Cellular Biotechnology, Dublin City University, Collins Avenue, Dublin 9, Ireland., Sabri S; Department of Pathology, McGill University, Faculty of Medicine, Department of Pathology, 1001 Decarie Blvd, Montreal, H4A 3J1, QC, Canada., Abdulkarim B; Department of Oncology, McGill University, Faculty of Medicine, Department of Oncology, 1001 Decarie Blvd, Montreal, H4A 3J1, QC, Canada., Sheehan KM; Department of Pathology, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland., Kay EW; Department of Pathology, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland., Young LS; Department of Surgery, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland., Hill ADK; Department of Surgery, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland., Smith YE; Department of Surgery, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland., Hopkins AM; Department of Surgery, Royal College of Surgeons in Ireland, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland. annhopkins@rcsi.ie.

Publikováno v: Breast cancer research : BCR [Breast Cancer Res] 2018 Nov 20; Vol. 20 (1), pp. 140. Date of Electronic Publication: 2018 Nov 20.

Development of a personalized therapeutic strategy for ERBB-gene-mutated cancers.

Autor: Milewska M; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, ERC Smurfit Building, Dublin 9 Ireland., Cremona M; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, ERC Smurfit Building, Dublin 9 Ireland., Morgan C; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, ERC Smurfit Building, Dublin 9 Ireland., O'Shea J; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, ERC Smurfit Building, Dublin 9 Ireland., Carr A; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, ERC Smurfit Building, Dublin 9 Ireland., Vellanki SH; Department of Surgery, Royal College of Surgeons in Ireland, ERC Smurfit Building, Dublin 9 Ireland., Hopkins AM; Department of Surgery, Royal College of Surgeons in Ireland, ERC Smurfit Building, Dublin 9 Ireland., Toomey S; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, ERC Smurfit Building, Dublin 9 Ireland., Madden SF; Data Science Centre Royal College of Surgeons in Ireland, Ireland., Hennessy BT; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Ireland., Eustace AJ; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, ERC Smurfit Building, Dublin, 9, Ireland.

Publikováno v: Therapeutic advances in medical oncology [Ther Adv Med Oncol] 2018 Jan 09; Vol. 10, pp. 1758834017746040. Date of Electronic Publication: 2018 Jan 09 (Print Publication: 2018).

Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP.

Autor: Bangert A; University Children's Hospital, Ulm, Germany., Cristofanon S, Eckhardt I, Abhari BA, Kolodziej S, Häcker S, Vellanki SH, Lausen J, Debatin KM, Fulda S

Publikováno v: Oncogene [Oncogene] 2012 Nov 01; Vol. 31 (44), pp. 4677-88. Date of Electronic Publication: 2012 Jan 23.