State of affairs in use of steroids in diffuse intrinsic pontine glioma: an international survey and a review of the literature.

Autor: Veldhuijzen van Zanten SE; Division of Oncology/Haematology, Department of Paediatrics, VU University Medical Center (VUmc), De Boelelaan 1118, Room KTC4.027, 1081 HZ, Amsterdam, The Netherlands. s.veldhuijzen@vumc.nl., Cruz O; Department of Paediatric Oncology, Hospital Sant Joan de Déu (HSJD), Passeig Sant Joan de Déu, 2, Esplugues De Llobregat, 08950, Barcelona, Spain., Kaspers GJ; Division of Oncology/Haematology, Department of Paediatrics, VU University Medical Center (VUmc), De Boelelaan 1118, Room KTC4.027, 1081 HZ, Amsterdam, The Netherlands.; Princess Máxima Center of Pediatric Oncology, Lundlaan 6, 3584 EA, Utrecht, The Netherlands., Hargrave DR; Paediatric Oncology Unit, Great Ormond Street Hospital (GOSH), Great Ormond Street, London, WC1N 3JH, UK., van Vuurden DG; Division of Oncology/Haematology, Department of Paediatrics, VU University Medical Center (VUmc), De Boelelaan 1118, Room KTC4.027, 1081 HZ, Amsterdam, The Netherlands.

Publikováno v: Journal of neuro-oncology [J Neurooncol] 2016 Jul; Vol. 128 (3), pp. 387-94. Date of Electronic Publication: 2016 May 13.

Palliative and end-of-life care for children with diffuse intrinsic pontine glioma: results from a London cohort study and international survey.

Autor: Veldhuijzen van Zanten SE; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., van Meerwijk CL; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., Jansen MH; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., Twisk JW; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., Anderson AK; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., Coombes L; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., Breen M; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., Hargrave OJ; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., Hemsley J; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., Craig F; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., Cruz O; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., Kaspers GJ; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., van Vuurden DG; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.)., Hargrave DR; Department of Pediatrics, Division of Oncology/Hematology, VU University Medical Center Amsterdam, Netherlands (S.E.M.V.v.Z., C.L.L.I.v.M., M.H.A.J., G.J.L.K., D.G.v.V.); Department of Epidemiology and Biostatistics, VU University Medical Center Amsterdam, Netherlands (J.W.R.T.); Paediatrics Unit, Royal Marsden NHS Foundation Trust, Sutton, UK (A.-K.A., L.C., M.B.); Department of Oncology, Great Ormond Street Hospital, London, UK (O.J.H., J.H., F.C., D.R.H.); Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain (O.C.).

Publikováno v: Neuro-oncology [Neuro Oncol] 2016 Apr; Vol. 18 (4), pp. 582-8. Date of Electronic Publication: 2015 Oct 11.

Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria.

Autor: Jansen MH; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Veldhuijzen van Zanten SE; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Sanchez Aliaga E; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Heymans MW; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Warmuth-Metz M; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Hargrave D; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, van der Hoeven EJ; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Gidding CE; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, de Bont ES; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Eshghi OS; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Reddingius R; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Peeters CM; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Schouten-van Meeteren AY; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Gooskens RH; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Granzen B; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Paardekooper GM; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Janssens GO; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Noske DP; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Barkhof F; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Kramm CM; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Vandertop WP; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, Kaspers GJ; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi, van Vuurden DG; Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi

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