Inhibition of NRF2 signaling overcomes acquired resistance to arsenic trioxide in FLT3-mutated Acute Myeloid Leukemia.

Autor: Jebanesan DZP; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India.; Manipal Academy of Higher Education, Manipal, India., Illangeswaran RSS; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India., Rajamani BM; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India., Vidhyadharan RT; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India., Das S; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India., Bijukumar NK; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India., Balakrishnan B; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India.; Department of Integrative Biology, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, India., Mathews V; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India., Velayudhan SR; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India.; Adjunct Scientist, Centre for Stem Cell Research, A Unit of InStem Bengaluru, CMC Campus, Vellore, India., Balasubramanian P; Department of Hematology, Christian Medical College Vellore-Ranipet Campus, Tamil Nadu, Vellore, 632517, India. bpoonkuzhali@cmcvellore.ac.in.

Publikováno v: Annals of hematology [Ann Hematol] 2024 Jun; Vol. 103 (6), pp. 1919-1929. Date of Electronic Publication: 2024 Apr 17.

Efficient deletion of microRNAs using CRISPR/Cas9 with dual guide RNAs.

Autor: Ijee S; 1 Centre for Stem Cell Research (A Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Department of Biotechnology, Thiruvalluvar University, Vellore, India., Chambayil K; 1 Centre for Stem Cell Research (A Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Sree Chitra Tirunal Institute of Science and Medical Technology, Thiruvananthapuram, India., Chaudhury AD; Department of Haematology, Christian Medical College Campus, Vellore, India.; Regional Centre for Biotechnology, New Delhi, India., Bagchi A; 1 Centre for Stem Cell Research (A Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India., Modak K; Department of Haematology, Christian Medical College Campus, Vellore, India.; Regional Centre for Biotechnology, New Delhi, India., Das S; Department of Biotechnology, Thiruvalluvar University, Vellore, India.; Department of Haematology, Christian Medical College Campus, Vellore, India., Benjamin ESB; Sree Chitra Tirunal Institute of Science and Medical Technology, Thiruvananthapuram, India.; Department of Haematology, Christian Medical College Campus, Vellore, India., Rani S; 1 Centre for Stem Cell Research (A Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Department of Biotechnology, Thiruvalluvar University, Vellore, India., Paul DZ; Department of Haematology, Christian Medical College Campus, Vellore, India.; Manipal Academy of Higher Education, Manipal, India., Nath A; 1 Centre for Stem Cell Research (A Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India., Roy D; Department of Haematology, Christian Medical College Campus, Vellore, India.; Manipal Academy of Higher Education, Manipal, India., Palani D; 1 Centre for Stem Cell Research (A Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India., Priyanka S; Department of Haematology, Christian Medical College Campus, Vellore, India., Ravichandran R; Department of Haematology, Christian Medical College Campus, Vellore, India., Kumary BK; Department of Haematology, Christian Medical College Campus, Vellore, India., Sivamani Y; Department of Haematology, Christian Medical College Campus, Vellore, India., S V; Department of Biotechnology, Thiruvalluvar University, Vellore, India., Babu D; 1 Centre for Stem Cell Research (A Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India., Nakamura Y; Cell Engineering Division, RIKEN BioResource Research Center, Tsukuba, Japan., Thamodaran V; 1 Centre for Stem Cell Research (A Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Tata Institute of Genetics and Society, Bengaluru, India., Balasubramanian P; Department of Haematology, Christian Medical College Campus, Vellore, India., Velayudhan SR; 1 Centre for Stem Cell Research (A Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.; Department of Haematology, Christian Medical College Campus, Vellore, India.

Publikováno v: Frontiers in molecular biosciences [Front Mol Biosci] 2024 Apr 02; Vol. 10, pp. 1295507. Date of Electronic Publication: 2024 Apr 02 (Print Publication: 2023).

Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression.

Autor: Rajendiran V; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala 695 011, India., Devaraju N; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India; Manipal Academy of Higher Education, Manipal, Karnataka 576104, India., Haddad M; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Ravi NS; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala 695 011, India., Panigrahi L; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India; Manipal Academy of Higher Education, Manipal, Karnataka 576104, India., Paul J; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India; Manipal Academy of Higher Education, Manipal, Karnataka 576104, India., Gopalakrishnan C; Department of Integrative Biology, School of Bioscience and Technology, Vellore Institute of Technology (VIT, Deemed to be University), Vellore, Tamil Nadu 632014, India., Wyman S; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94704, USA., Ariudainambi K; Department of Biochemistry, Auxilium College, Vellore, Tamil Nadu 632006, India., Mahalingam G; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India., Periyasami Y; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India., Prasad K; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India; Manipal Academy of Higher Education, Manipal, Karnataka 576104, India., George A; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala 695 011, India., Sukumaran D; Department of Integrative Biology, School of Bioscience and Technology, Vellore Institute of Technology (VIT, Deemed to be University), Vellore, Tamil Nadu 632014, India., Gopinathan S; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India., Pai AA; Department of Haematology, Christian Medical College & Hospital, Vellore, Tamil Nadu 632 004, India., Nakamura Y; Cell Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan., Balasubramanian P; Department of Haematology, Christian Medical College & Hospital, Vellore, Tamil Nadu 632 004, India., Ramalingam R; Department of Integrative Biology, School of Bioscience and Technology, Vellore Institute of Technology (VIT, Deemed to be University), Vellore, Tamil Nadu 632014, India., Thangavel S; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India., Velayudhan SR; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India; Department of Haematology, Christian Medical College & Hospital, Vellore, Tamil Nadu 632 004, India., Corn JE; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94704, USA; Institute of Molecular Health Sciences, Department of Biology, Zurich, Switzerland., Mackay JP; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia., Marepally S; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India., Srivastava A; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India; Department of Haematology, Christian Medical College & Hospital, Vellore, Tamil Nadu 632 004, India., Crossley M; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Mohankumar KM; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Bagayam, Vellore, Tamil Nadu 632002, India. Electronic address: mohankumarkm@cmcvellore.ac.in.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Mar 06; Vol. 32 (3), pp. 663-677. Date of Electronic Publication: 2024 Jan 24.

Establishment and characterization of CSCRi006-A: an induced pluripotent stem cell line generated from a patient with Diamond-Blackfan Anemia (DBA) carrying ribosomal protein S19 (RPS19) mutation.

Autor: Rani S; Centre for Stem Cell Research, Christian Medical College, Vellore, India.; Department of Biotechnology, Thiruvalluvar University, Vellore, India., Thamodaran V; Centre for Stem Cell Research, Christian Medical College, Vellore, India.; Tata Institute for Genetics and Society, Bangalore, India., Nandy K; Centre for Stem Cell Research, Christian Medical College, Vellore, India.; Department of Biotechnology, Thiruvalluvar University, Vellore, India., Fouzia NA; Department of Hematology, Christian Medical College, Vellore, India., Maddali M; Department of Hematology, Christian Medical College, Vellore, India., Rajesh P; Centre for Stem Cell Research, Christian Medical College, Vellore, India., Vijayanand S; Department of Biotechnology, Thiruvalluvar University, Vellore, India., David E; Department of Biotechnology, Thiruvalluvar University, Vellore, India., Velayudhan SR; Centre for Stem Cell Research, Christian Medical College, Vellore, India. rvshaji@cmcvellore.ac.in.; Department of Hematology, Christian Medical College, Vellore, India. rvshaji@cmcvellore.ac.in.

Publikováno v: Human cell [Hum Cell] 2023 Nov; Vol. 36 (6), pp. 2204-2213. Date of Electronic Publication: 2023 Aug 21.

Comprehensive laboratory diagnosis of Fanconi anaemia: comparison of cellular and molecular analysis.

Autor: Joshi G; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India.; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India., Arthur NBJ; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India., Geetha TS; MedGenome Laboratories Pvt Ltd, Bangalore, India., Datari PVR; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India., Modak K; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India., Roy D; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India.; Manipal Academy of Higher Education, Manipal, Karnataka, India., Chaudhury AD; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India., Sundaraganesan P; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India., Priyanka S; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India., Na F; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India., Ramprasad V; MedGenome Laboratories Pvt Ltd, Bangalore, India., Abraham A; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India., Srivastava VM; Department of Cytogenetics, Christian Medical College Vellore, Vellore, Tamil Nadu, India., Srivastava A; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India.; Center for Stem Cell Research, Vellore, Tamil Nadu, India., Kulkarni UP; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India., George B; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India., Velayudhan SR; Department of Haematology, Christian Medical College Vellore, Vellore, Tamil Nadu, India rvshaji@cmcvellore.ac.in.; Center for Stem Cell Research, Vellore, Tamil Nadu, India.

Publikováno v: Journal of medical genetics [J Med Genet] 2023 Aug; Vol. 60 (8), pp. 801-809. Date of Electronic Publication: 2023 Mar 09.