Identification of 2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-N-phenylpropanamides as a novel class of potent DprE1 inhibitors

Autor: Whitehurst, Benjamin C., Young, Robert J., Burley, Glenn A., Cacho, Monica, Torres, Pedro, Vela-Gonzalez del Peral, Laura

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 15 June 2020 30(12)

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

Autor: Cox, Jonathan A. G., Mugumbate, Grace, Vela González del Peral, Laura, Jankute, Monika, A. Abrahams, Katherine, Jervis, Peter, Jackenkroll, Stefan, Pérez, Arancha, Alemparte, Carlos, Esquivias, Jorge, Lelièvre, Joël, Ramón Olayo, Fernando Antonio, Barros, David, Ballell, Lluis, S. Besra, Gurdyal

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Scientific Reports
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
E-Prints Complutense. Archivo Institucional de la UCM
instname

High-throughput phenotypic screens have re-emerged as screening tools in antibiotic discovery. The advent of such technologies has rapidly accelerated the identification of ‘hit’ compounds. A pre-requisite to medicinal chemistry optimisation prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6ede70eea2cc6a335e7385e19c4c0485
https://publications.aston.ac.uk/id/eprint/29750/1/Novel_inhibitors_of_Mycobacterium_tuberculosis_GuaB2.pdf