Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial

Autor: Verusca Lecchi, Pamela Surtees, Jessie A. Hermann, Marina Noutsou, Lidmila Francová, Francesca Lo Bue, Silvia Prandini, Annika Durban, Heidrun Wölk, Suzy van Steenderen, Gemma Currie, Rüdiger Göke, Ivan Rychlik, Daniela Cugini, Annette Busmann, Ulrike Wittkop, Svitlana Yakymchuk, John R. Petrie, Slavica S. Stratrova, Stanley M H Yeung, Julia Raad, Antonio Cannata, Ninna Hahn Tougaard, Robbie Wilson, Barbara Neuhaus, Joachim Beige, Olivera Stojceva-Taneva, Harald Mischak, Tine W. Hansen, Giulia Gherardi, Caroline Boukens-de Graaf, Renata Amanaki, Francesco Nones, Anneke K. De Bruin, Aneliya Parvanova, Elizabeth Douglas, Carolina Aparicio, Gerjan Navis, Tereza Havrdova, Alberto Ortiz, Maria Dolores Sanchez-Niño, Simone Theilade, Ferrina Clerc-de Jong, Signe Abitz Winther, Adrian M. Ramos, Regina Ax-Smolarski, Ingo Dimos, Christina M. Gant, Peter Girman, Friedrich W. Petry, Peter Rossing, Bruno Lapauw, Katarina Adamova, Rikke J. Stefansen, Michael Prigge, Mie K. Eickhoff, Petra Zürbig, Viktor Rotbain Curovic, Davide Villa, Goce Spasovski, Marian Nannings, Adriaan Kooy, Joanne Flynn, Therese Frost Lerche, Veit Zieglschmid, Flavio Gaspari, Gjulsen Selim, Marijn M. Speeckaert, Jens C. Laursen, Elsie de Man, Signe Rosenlund, Christian Delles, Giel Nijpels, Katriona Brooksbank, Alessandro Villa, Ilian Iliev, Morten Lindhardt, Maria A. Campbell, Lone Jelstrup, Gozewijn D. Laverman, Matias Trillini, Ulrike Schmidt, Kristin Kreutzmann, Silke Zimmermann, Ceyda Kilic, Tina R. Juhl, Silvia Ferrari, Nadia Stucchi, Beatriz Fernandez-Fernandez, Christian Stevns Hansen, Femke Rutters, Brenda Wierbos, Sabien Inion, Maria Lajer, Justyna Siwy, Jannet Entius, Sascha Pilemann-Lyberg, Lene Aabo, Heiko von der Leyen, Elina Eldeik, Tatjana Gjorgovski, Marie Frimodt-Møller, Isabelle Dewettinck, Maja L.D. Halkjær, Joline W.J. Beulens, Šárka Albrechtová, Stephan J. L. Bakker, Hiddo J.L. Heerspink, Brit Rädisch, Clotilde Vázquez, Ilse J. M. Hagedoorn, Dorthe Riis, Bernt Johan von Scholten, Andreas L. Birkenfeld, Kelly Rokegem, Ana Belen Sanz, Frederik Persson, Eva Bollweber, Anika Hävemeier, Frank Huvers, Petra Schutten-Westerneng, Piero Ruggenenti, Sharon Kean, Maria Á. Gonzalo, Anne G. Lundgaard, Marco Schiemann, Emilie H. Zobel, Nete Tofte, Joe Galloway, Daniela Melacini, Jinny Sanchez-Rodriguez

Publikováno v: Lancet Diabetes & Endocrinology, 8(4), 301-312. ELSEVIER SCIENCE INC
Tofte, N, Lindhardt, M, Adamova, K, Bakker, S J L, Beige, J, Beulens, J W J, Birkenfeld, A L, Currie, G, Dimos, I, Francová, L, Frimodt-Møller, M, Girman, P, Göke, R, Havrdova, T, Heerspink, H J L, Kooy, A, Laverman, G D, Mischak, H, Navis, G, Nijpels, G, Noutsou, M, Ortiz, A, Parvanova, A, Persson, F, Petrie, J R, Ruggenenti, P L, Rutters, F, Rychlík, I, Siwy, J, Spasovski, G, Speeckaert, M, Trillini, M, Zürbig, P, von der Leyen, H, Rossing, P, PRIORITY investigators & Nijpels, MGAAM 2020, ' Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY) : a prospective observational study and embedded randomised placebo-controlled trial ', The Lancet Diabetes and Endocrinology, vol. 8, no. 4, pp. 301-312 . https://doi.org/10.1016/S2213-8587(20)30026-7
Ann Transl Med
The Lancet Diabetes and Endocrinology, 8(4), 301-312. Elsevier BV
Lancet Diabet. Endocrinol. 8, 301-312 (2020)

Background: \ud Microalbuminuria is an early sign of kidney disease in people with diabetes and indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic risk classifier (CKD273) score was associated with development o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c330f7cf6c46dc4a204c768eaea4bed
https://eprints.gla.ac.uk/212534/13/212534.pdf

Heterogeneous expression of tumor-associated genes in disseminated breast cancer cells

Autor: Veit, Zieglschmid, Christiane, Hollmann, Bertha, Gutierrez, Andreas, Krehan, Sepp, Kaul, Oliver, Böcher

Publikováno v: Anticancer research. 27(4A)

Gene expression profiles were determined to demonstrate heterogeneity of viable disseminated tumor cells (DTC) in the blood of breast cancer patients.All patients (n = 48) suffered from metastatic disease (M1) and were treated with chemotherapy and/o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2717c800dde51d17ecdb6d63bfa6206a
https://pubmed.ncbi.nlm.nih.gov/17649771

The clinical significance of circulating tumour cells in breast cancer and colorectal cancer patients

Autor: Siegfried, Hauch, Silke, Zimmermann, Silke, Lankiewicz, Veit, Zieglschmid, Oliver, Böcher, Winfried Hans, Albert

Publikováno v: Anticancer research. 27(3A)

Circulating tumour cells (CTC) in the blood of cancer patients indicate disease progression. Their presence reflects a relapse or metastasising process since CTC survive only a short time in the circulation.Test systems developed by AdnaGen have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::643bc53a52784ccd41c7c98378b7a71f
https://pubmed.ncbi.nlm.nih.gov/17593628