SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain

Autor: Yurkovetskiy, Leonid, Pascal, Kristen E, Tompkins-Tinch, Christopher, Nyalile, Thomas, Wang, Yetao, Baum, Alina, Diehl, William E, Dauphin, Ann, Carbone, Claudia, Veinotte, Kristen, Egri, Shawn B, Schaffner, Stephen F, Lemieux, Jacob E, Munro, James, Sabeti, Pardis C, Kyratsous, Christos, Shen, Kuang, Luban, Jeremy

Publikováno v: bioRxiv

Virus genome sequence variants that appear over the course of an outbreak can be exploited to map the trajectory of the virus from one susceptible host to another. While such variants are usually of no functional significance, in some cases they may

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https://europepmc.org/articles/PMC7337374/

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Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.

Autor: Yurkovetskiy L; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.; These authors contributed equally to this work., Wang X; Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG Eindhoven, Netherlands.; These authors contributed equally to this work., Pascal KE; Regeneron Pharmaceutical, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY 10591., Tomkins-Tinch C; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA., Nyalile T; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Wang Y; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Baum A; Regeneron Pharmaceutical, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY 10591., Diehl WE; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Dauphin A; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Carbone C; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Veinotte K; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Egri SB; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Schaffner SF; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA., Lemieux JE; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114., Munro J; D epartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Rafique A; Regeneron Pharmaceutical, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY 10591., Barve A; Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG Eindhoven, Netherlands., Sabeti PC; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.; Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, 02115 Boston, MA.; Howard Hughes Medical Institute, 4000 Jones Bridge Rd, Chevy Chase, MD 20815.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115., Kyratsous CA; Regeneron Pharmaceutical, Inc., 777 Old Saw Mill River Rd, Tarrytown, NY 10591., Dudkina N; Thermo Fisher Scientific, Achtseweg Noord 5, 5651 GG Eindhoven, Netherlands., Shen K; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA., Luban J; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.; Broad Institute of Harvard and MIT, 75 Ames Street, Cambridge, MA 02142, USA.; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, 02115.; Lead contact.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Jul 15. Date of Electronic Publication: 2020 Jul 15.